Prevalence, characteristics and challenges of late HIV diagnosis in Germany: an expert narrative review

Boesecke, Christoph; Schellberg, Sven; Schneider, Ján; Schuettfort, Gundolf; Stocker, Hartmut

doi:10.1007/s15010-023-02064-1

Cited by 7 publications

(3 citation statements)

References 77 publications

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“…The assessment of predictors yielded expected results, revealing late-stage HIV infection as a potential predictor for resistance development. Patients diagnosed at a late stage of HIV infection are known to be at a higher risk of treatment failure than those diagnosed at an early stage due to resistance development, likely attributed to the presence of opportunistic infections and concurrent treatments, potentially leading to adverse effects and drug-drug interactions that impact therapy effectiveness [33,34].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HIV drug resistance at antiretroviral treatment failure across regions of Russia

Ozhmegova,

Lebedev,

Antonova

et al. 2024

HIV Medicine

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BackgroundThis study aimed to investigate mutations associated with, the causes of, and the conditions that contribute to HIV drug resistance (DR). This research provides crucial insights into the mechanisms through which HIV evades antiretroviral drugs and suggests strategies to counter this phenomenon. Our objective was to assess the prevalence and structure of DR in HIV‐1 across various regions in Russia and identify the primary factors influencing the development of HIV DR.MethodsThe study used nucleotide sequences from the HIV‐1 pol gene obtained from 1369 patients with a history of therapy and virological failure between 2005 and 2019 to analyze the frequency and structure of DR and the factors associated with it.ResultsThe analysed HIV‐1 genotypes included viruses resistant to nucleoside reverse transcriptase inhibitors (NRTIs; 11.8%), non‐nucleoside reverse transcriptase inhibitors (NNRTIs; 6.4%), and NRTIs + NNRTIs (31.7%). The mutations M184V/I and G190A/S/E were the most prevalent, accounting for 54.5% and 26.6%, respectively. The dominance of multiple DR persisted throughout the entire observation period. The likelihood of encountering drug‐resistant variants was increased among men, patients in the late stage of infection, and those with a viral load <30 000 RNA copies/mL. Injection drug use was not associated with DR.ConclusionThis study has yielded new insights into HIV DR in Russia, offering valuable information to identify clinical or programmatic events warranting closer attention and support.

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Section: Discussionmentioning

confidence: 99%

Prevalence of HIV drug resistance at antiretroviral treatment failure across regions of Russia

Ozhmegova,

Lebedev,

Antonova

et al. 2024

HIV Medicine

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“…These policies also seek to increase testing coverage and reinforce the adoption of HIV prevention and treatment services. Nevertheless, a substantial number of People Living with HIV (PLHIV) remain unaware of their infection or receive late diagnoses in countries with varying levels of development and income [ 2 , 3 ], thereby jeopardizing the achievement of epidemic-ending targets [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Late Diagnosis of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

Arantes,

Pedroso,

Menegueti

et al. 2023

Viruses

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Introduction: This study aimed to identify factors associated with late diagnosis and clinically monitor newly diagnosed HIV/AIDS patients. Method: Retrospective study, based on secondary data from a specialized unit at the Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto of the University of Sao Paulo. Data collection included sociodemographic, behavioral, clinical, and laboratory data of newly diagnosed HIV patients between 2015 and 2019. Data analysis was undertaken using inferential statistical tests. Results: A total of 314 individuals were newly diagnosed with HIV/AIDS, 86.6% (272) had a late diagnosis and 53.8% (169) were diagnosed very late. Using the adjusted odds ratio, we observed that bisexual and MSM patients were less likely to have a late diagnosis compared to straight patients. Individuals who entered through the emergency department and Outpatient Clinic had a lower chance of having a very late diagnosis compared to those diagnosed in the ward/inpatient unit. Having a higher education and university education were protective factors against having a very late diagnosis of HIV infection compared to elementary school education only. In addition, male patients were more likely to have a very late diagnosis compared to female patients. Conclusions: This study evidenced a high prevalence of late and very late diagnoses. Therefore, attention should be directed towards factors related to late and very late presentation.

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“…Viruses 2023, 15, 2097 2 of 13 testing coverage and reinforce the adoption of HIV prevention and treatment services. Nevertheless, a substantial number of People Living with HIV (PLHIV) remain unaware of their infection or receive late diagnoses in countries with varying levels of development and income [2,3], thereby jeopardizing the achievement of epidemic-ending targets [2].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Late Diagnosis of HIV/AIDS in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

Arantes¹,

Pedroso²,

Menegüeti³

et al. 2023

Preprint

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Introduction: This study aimed to identify factors associated with late diagnosis and clinically monitor newly diagnosed HIV/AIDS patients. Method: Retrospective longitudinal study, based on secondary data from a specialized unit at a tertiary hospital. Data collection included sociodemographic, behavioral, clinical, and laboratory data of newly diagnosed HIV patients between 2015-2019. Data analysis adopted inferential statistical tests using the SPSS program, considering α ≤ 0.05. Results: 314 individuals were newly diagnosed with HIV/AIDS. 70.3% (208) had a late diagnosis, and 57.1% (169) were diagnosed very late. There was an association of the very late diagnosis with the variables sex and education and with origin, entry, occurrence of opportunistic diseases, use of ARV therapy, and death, associated with late and very late diagnosis, respectively. The results of the regression model indicate that males had 2.28 [95% CI 1.11 - 4.46] higher chances of having a late diagnosis compared to females. Conclusions: This study evidenced a high prevalence of late and very late diagnoses in newly diagnosed male HIV patients who presented with opportunistic diseases, requiring hospitalization, and having a significant risk of progressing to death.

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Prevalence, characteristics and challenges of late HIV diagnosis in Germany: an expert narrative review

Cited by 7 publications

References 77 publications

Prevalence of HIV drug resistance at antiretroviral treatment failure across regions of Russia

Prevalence of HIV drug resistance at antiretroviral treatment failure across regions of Russia

Factors Associated with Late Diagnosis of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

Factors Associated with Late Diagnosis of HIV/AIDS in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

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