Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of
            <i>Streptococcus pneumoniae</i>
            at Five Tertiary-Care Hospitals in Korea

Shin, Jeong Hwan; Jung, Hee Jung; Kim, Hye Ran; Jeong, Joseph; Jeong, Seok Hoon; Kim, Sun‐Joo; Lee, Eun Yup; Lee, Jeong Nyeo; Chang, Chulhun L.

doi:10.1128/aac.00107-07

Cited by 16 publications

(8 citation statements)

References 19 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the MRSP tested, 94.8% (92/97) were erm-or erm + mef-positive. This result is consistent with previous studies of strains isolated from Shanghai and other Asian cities [11,17,[31][32][33] showing a predominance of macrolide resistance associated with the erm(B) gene. Macrolide resistance in strains from North America are primarily associated with efflux pumps via the mef(E) gene, although an increase in strains harbouring both the erm and mef genes is evident from recent studies [3,34,35].…”

Section: Discussionsupporting

confidence: 94%

Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China

Yang

et al. 2008

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 94%

Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China

Yang

et al. 2008

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

“…In this study, we found that erythromycin resistance and MDR of all pneumococci from 20 primary clinics were 82.9% and 56.1%, respectively, which are similar to previous data based on some tertiary hospitals in Korea. 25,26 However, as we applied the new CLSI breakpoint of S. pneumoniae for penicillin in this study, the rate of nonsusceptibility was 27.9% (but the penicillin resistance was 80.4% based on the previous breakpoint for penicillin of CLSI). Of note, the full resistance rate was only 4.0% (MIC !8 mg=ml).…”

Section: Discussionmentioning

confidence: 96%

Prevalence of Serotype and Multidrug-Resistance of Streptococcus pneumoniae Respiratory Tract Isolates in 265 Adults and 36 Children in Korea, 2002–2005

Lee

Kang

et al. 2010

Microbial Drug Resistance

View full text Add to dashboard Cite

In total, 301 isolates of Streptococcus pneumoniae collected from patients with respiratory tract infections admitted at primary clinics during 2002-2005 were tested for multidrug-resistance (MDR) phenotypes and their serotypes in Korea. The predominant serotypes were 19F, 19A, 23F, 11A, 3, 6A, and 6B, accounting for 67.8% of all isolates. Their serotype coverage by 23-valent polysaccharide vaccine and 7-valent conjugation vaccine was 73.1% and 39.2%, respectively. For the application of Clinical and Laboratory Standards Institute's new breakpoint for penicillin, the resistance rate of penicillin was 27.9% (but the penicillin resistance was 80.4% based on the previous breakpoint for penicillin of Clinical and Laboratory Standards Institute). Actually, the full resistance rate was only 4.0% (minimum inhibitory concentration >or=8 mg/L). Resistances to erythromycin, clindamycin, and tetracycline were very high (82.9%, 79.4%, and 71.7%, respectively). Especially, 56.1% of all the isolates were MDR, defined as resistant to three or more of the following agents: penicillin, erythromycin, clindamycin, cefotaxime, tetracycline, and levofloxacin. MDR strains were relatively associated with serotypes 19F, 19A, 23F, and 11A, accounting for 58.0% of the isolates. Their serotype coverage by 23-valent polysaccharide vaccine and 7-valent conjugation vaccine was 79.5% and 45.9%, respectively. Levofloxacin, as a representative fluoroquinolone, was active against 88.2% of all MDR isolates. Of particular concern was the high prevalence of MDR pneumococci in non-PCV7 serotypes with an MDR serotype 19A, 11A, 3, and 6A being mostly responsible. It would be prudent to consider more efficient protective strategies for people at high risk for pneumococcal diseases in regions with a high prevalence of MDR pneumococci.

show abstract

“…Marked differences among pneumococcal isolates have been reported worldwide, and especially high non‐susceptibility rates of up to 81.6% are found in Asia [6,21]. Although increasing rates of fluoroquinolone resistance have been described in some previous reports, especially for Hong Kong and Korea, but also for Canada, the USA, Mexico, and Japan, the rate of resistance remains relatively low worldwide [21,23–27]. While levofloxacin resistance was very low or absent in other European countries, in Germany the level of levofloxacin non‐susceptibility detected (0.4%) has remained at the same level as recorded in 2001–2003 [26].…”

Section: Discussionmentioning

confidence: 99%

Adult invasive pneumococcal disease between 2003 and 2006 in North-Rhine Westphalia, Germany: serotype distribution before recommendation for general pneumococcal conjugate vaccination for children <2 years of age

Imöhl

Reinert²,

Linden

2009

Clinical Microbiology and Infection

View full text Add to dashboard Cite

A laboratory-based surveillance study of adult invasive pneumococcal disease was conducted in North-Rhine Westphalia, Germany's most populous federal state, with approximately 18 million inhabitants. Invasive isolates (n = 519) were obtained between 2003 and 2006, before the general recommendation for vaccination of German children <2 years with the pneumococcal conjugate vaccine was issued at the end of July 2006. Penicillin G resistance was observed in 5% of meningitis cases. In the non-meningitis group, only intermediately resistant strains were detected (0.4%). Intermediate resistance to cefotaxime occurred both in meningitis cases (1.7%) and non-meningitis cases (0.4%). Non-susceptibility rates (intermediate resistance and resistance) were 16.2% for macrolides, 10.9% for trimethoprim-sulphamethoxazole, 5.0% for tetracycline, 3.9% for clindamycin, and 0.4% for levofloxacin. All isolates were susceptible to amoxycillin (non-meningitis) and telithromycin. The leading serotypes were serotypes 14 (14.3%), 7F (9.4%), 3 (9.2%), 4 (8.7%) and 1 (8.1%). Serotype coverage for the seven-valent conjugate vaccine was 43.9%. For the ten-valent and 13-valent vaccines (in development), the coverages were 61.8% and 76.7%, respectively. The 23-valent polysaccharide vaccine had a coverage of 91.1%.

show abstract

Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea

Cited by 16 publications

References 19 publications

Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China

Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China

Prevalence of Serotype and Multidrug-Resistance of Streptococcus pneumoniae Respiratory Tract Isolates in 265 Adults and 36 Children in Korea, 2002–2005

Adult invasive pneumococcal disease between 2003 and 2006 in North-Rhine Westphalia, Germany: serotype distribution before recommendation for general pneumococcal conjugate vaccination for children <2 years of age

Contact Info

Product

Resources

About