Prevalence, Characteristics and Predictive Factors of Microalbuminuria in Resistant Systemic Arterial Hypertension

Gadau, Carmen; Ardeleanu, Elena; Folescu, Roxana; Ţilea, Ioan; Varga, Andreea; Zamfir, Alexandra Simona; Boanca, Mihaela; Dobrin, Romeo; Strat, Liliana; Baaj, Teim; Nicola, Patricia; Luca, Alina Costina; Gurguş, Daniela

doi:10.37358/rc.18.9.6546

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The high prevalence of a non-dipper pattern was also influenced by the presence of diabetes, advanced age and association of other risk factors as dyslipidaemia. The elevated BP levels and the absence of the physiological nocturnal BP dipping has high predictive values for organ damage and worse prognosis [15]. Many trials confirm the observation that the control rate of hypertensive patients with CKD is worst during night and better during daytime [16][17].…”

Section: Resultsmentioning

confidence: 99%

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Baaj¹,

Abu-Awwad²,

Botoca³

et al. 2020

Rev. Chim.

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Accelerated atherosclerosis and cardiovascular diseases are frequent complications in hypertensive patients with chronic kidney disease (CKD), being mainly driven by cardiovascular risk factors as lipid disorders and an unfavorable blood pressure profile. The objectives of the study were to evaluate the lipid profile and to assess the characteristics of blood pressure (BP) in patients with primary arterial hypertension associating chronic kidney disease (CKD) in a primary care population in Timis County, Romania. Lipid disorders were highly prevalent in hypertensive patients with CKD, consisting in hyper LDL-cholesterolemia in 50.3%, hypertriglyceridemia in 52%, low HDL-cholesterol levels in 35.8%. More than 2 lipid abnormalities were present in 68.8% of CKD hypertensive. CKD hypertensive patients, compared with those without CKD, presented a BP profile with higher systolic and diastolic office BP. On ambulatory blood pressure monitoring they also registred higher systolic and diastolic BP, the systolic BP (SBP), both for 24 h SBP, day-time and night-time SBP being statistically significant higher than in hypertensive patients without CKD. The circadian 24 h BP profile demonstrated in the CKD hypertensive population an unfavourable nocturnal profile in 67%, consisting of a high prevalence of the non-dipping profile and of nocturnal riser pattern.

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Section: Resultsmentioning

confidence: 99%

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Baaj¹,

Abu-Awwad²,

Botoca³

et al. 2020

Rev. Chim.

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“…One of the most important causes of worldwide morbidity and mortality is systemic arterial hypertension (SAH), which is responsible for the reduction of life expectancy and quality of life (GADAU et al, 2018). Its association with diabetes mellitus (DM) is frequent, consistently increasing the risk of cardiovascular diseases (CVDs) at any stage of hypertension, which may lead to other comorbidities like dyslipidemia, thus configuring a condition named metabolic syndrome (MetSyn) (ROLIM et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Fernandes¹,

Oltramari²,

Nardo³

et al. 2021

Rev. Cont. Saúde

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Metabolic syndrome (MetSyn) is a disorder that involves a series of symptoms that are associated to obesity and metabolic modifications, and increases the risk of developing cardiovascular disease and type 2 diabetes Mellitus. The study of new possibilities of non-drug therapies is fundamental for the primary prevention of MetSyn. The aim of this work was to evaluate the responses of spontaneously hypertensive rats (SHR) with lipid changes induced by the administration of dexamethasone (DEXA) to the ingestion of flaxseed oil associated or not associated with physical exercise regarding the body weight, and glycemic and lipid profiles, in comparison with the drug treatment with metformin. After 24 days of experiment, the 20-week-old animals were submitted to the glucose tolerance test (GTT) and lipid profile evaluation. The results showed that the administration of DEXA in SHR animals promoted a framework of hyperglycemia, dyslipidemia and attenuated the insulin resistance common in the SHR, thus producing an experimental model with several components of the human MetSyn. The effects on weight gain indicated an important preventive action of flaxseed oil and exercise on the weight evolution of SHR-DEXA animals. Furthermore, the ingestion of flaxseed oil associated or not with exercise promoted significant improvements on hyperglycemia and glucose intolerance in these animals. Regarding the lipid profile, the treatments with flaxseed oil and exercise promoted reductions in triglyceride levels and HDL-c increase; however, the combination of these two non-drug interventions was more effective than the isolated treatments.

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“…There are few Romanian studies [10][11][12] on essential arterial hypertension associating CKD and about hypertension mediated organ damage (HMOD) in CKD patients. As the epidemiology and characteristics of hypertension with CKD differs, it is important to have national studies to evaluate the local situation and to elaborate on this basis prevention, diagnosis and therapy strategies [13,14]. The aim of the present study was to evaluate in hypertension with CKD (1) the induced vascular damage, evaluated with carotid intima-media thickness, carotid plaques and ankle brachial index (ABI); (2) the heart response to hypertension, respectively the left ventricular hypertrophy and (3) to establish the correlation between these organ damage, hypertension, CKD and associated clinical and biochemical cardiovascular risk factors.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Paraclinical Evaluation of Organ Damage in Arterial Hypertension with Associated Chronic Kidney Disease

Baaj¹,

Abu-Awwad²,

Botoca³

et al. 2020

Rev. Chim.

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Organ damages, which contribute to the overall cardiovascular risk of hypertensive patients, should be early detected, prevented and treated. The study evaluated organ damage in a hypertensive study group with chronic kidney disease (CKD), compared with a study group of hypertension without CKD. Albuminuria was present in 41.2% and reduced estimated glomerular filtration rate [60 ml/min/m2 was present in 72.5% of hypertensive with CKD. The comparison of organ damage revealed in the CKD group a statistical significant higher prevalence of organ damage as follows: intima-media thickness ]0.9 mm in 39.9% vs 10.5%, carotid plaques in 28.2% vs 12.6%, left ventricular hypertrophy in 39.9% vs 31%, ankle brachial index in 6.2% vs 3.5%. Early detection and treatment of additional cardiovascular risk factors as dyslipidaemia and hyperglycaemia, that have significant role in the pathogenesis of organ damage, contribute to the better prevention of cardiovascular and renal complications in hypertension with CKD.

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Prevalence, Characteristics and Predictive Factors of Microalbuminuria in Resistant Systemic Arterial Hypertension

Cited by 3 publications

References 18 publications

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Biochemical and Paraclinical Evaluation of Organ Damage in Arterial Hypertension with Associated Chronic Kidney Disease

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