Prevalence, Characteristics, and Prognosis of Peripheral Arterial Disease in Patients With Diabetic Charcot Foot

Orioli, Laura; Hammer, Frank; Berg, Bruno; Putineanu, Dan Constantin; Maiter, Dominique; Vandeleene, Bernard

doi:10.1053/j.jfas.2021.04.021

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…The higher rate of minor and major amputation reinforces the concept that PAD increases the risk of amputation, particularly in the case of concomitant DFU, in comparison to the presence of pure peripheral neuropathy where healing potential is greater [ 5 , 7 ]. The rate of major amputation in our cohort of patients is similar to that reported by Orioli et al (8 vs. 10%) [ 14 ] but lower than data reported by Cates et al (8 vs. 37%) [ 24 ], although in that last mentioned study they included only patients who underwent Charcot reconstruction, therefore with an additional risk for a negative outcome [ 24 ].…”

Section: Discussionsupporting

confidence: 87%

“…The data presented here is higher than that reported in a previous Italian study [ 21 ] in which the prevalence was 11%, but only hospitalized patients were considered. Even so, Wukich et al observed the prevalence of PAD could be as high as 40% in this group [ 13 ], whilst Oriali et al observed it reaching 66% [ 14 ]. These differences may represent the heterogeneity in inclusion criteria of samples and methods used to investigate PAD among included patients.…”

Section: Discussionmentioning

confidence: 96%

“…Accordingly, PAD in CN was commonly less investigated, although more recently some authors have reported that PAD may be a concomitant condition in CN. Today, only a few authors have investigated the presence of PAD in CN patients, identifying the prevalence range of PAD from 5 to 40% [ 13 , 14 ]. These differences may reflect the non-homogeneous inclusion criteria and different diagnostic methods used to detect PAD.…”

Section: Introductionmentioning

confidence: 99%

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The Neuro-Ischaemic Charcot Foot: Prevalence, Characteristics and Severity of Peripheral Arterial Disease in Acute Charcot Neuro-Arthropathy

Meloni

Ahluwalia

Bellia

et al. 2022

JCM

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The study aimed to evaluate the prevalence, characteristics and outcomes of patients affected by Charcot neuro-arthropathy (CN) and peripheral arterial disease (PAD) compared to CN without PAD. Consecutive patients presenting with an acute CN were included. The sample size was calculated by the power analysis by adopting the two-tailed tests of the null hypothesis with alfa = 0.05 and a value of beta = 0.10 as the second type error and, therefore, a test power equal to 90%. Seventy-six patients were identified. Twenty-four patients (31.6%) had neuro-ischaemic CN; they were older (66 vs. 57yrs), p = 0.03, had a longer diabetes duration (19 vs. 14yrs), p < 0.001, and more cases of end-stage-renal-disease (12.5 vs. 0%), p = 0.04 and ischaemic heart disease (58.3 vs. 15.4%), p < 0.0001 than neuropathic CN. Fifty patients (65.8%) had concomitant foot ulcers, 62.5% and 67.3% (p = 0.3), respectively, in CN with and without PAD. Neuro-ischaemic CN show arterial lesions of 2.9 vessels, and PAD was located predominantly below-the-knee (75%) but not below-the-ankle (16.7%). The outcomes for neuro-ischaemic and neuropathic CN patients were, respectively: wound healing (86.7 vs. 94.3%), p = 0.08; minor amputation (25 vs. 7.7%), p = 0.003; major amputation (8.3 vs. 1.9%), p = 0.001; hospitalization (75 vs. 23%), p = 0.0001. The study showed a frequent association between CN and PAD, leading to a neuro-ischaemic Charcot foot type. Neuro-ischaemic CN leaded to an increased risk of minor and major amputation and hospitalization, compared to neuropathic CN.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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The Neuro-Ischaemic Charcot Foot: Prevalence, Characteristics and Severity of Peripheral Arterial Disease in Acute Charcot Neuro-Arthropathy

Meloni

Ahluwalia

Bellia

et al. 2022

JCM

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“…Berdasarkan hasil penelitian yang didapatkan, distribusi frekuensi IMT pasien charcot foot dengan DM terbanyak ditemukan pada status nutrisi obesitas dengan nilai rerata dan median yang didapat adalah 27,2 kg/m² dan 25,8 kg/m². Hasil ini memiliki kesamaan dengan penelitian dari Orioli dkk., Dos Santos-Vaquinhas dkk., dan Jansen dkk., dimana nilai rerata yang didapat termasuk dalam status nutrisi obesitas 14,15,16 . Penelitian milik Orioli dkk.…”

Section: Pembahasanunclassified

“…Menurut tinjauan sistematis yang dilakukan oleh Mobasseri dkk., prevalensi dari T1DM di dunia hanya 5,9 per 10.000 dan prevalensi pada benua Asia 9,6 per 10.000 orang 19 Distribusi frekuensi berdasar kadar HbA1c didapatkan klasifikasi diabetes (dengan kadar ≥6,5% dominan dibanding klasifikasi lainnya. Rata-rata kadar HbA1c dari total kasus penelitian ini adalah 9,0 ± 2,6% dan median nya adalah 8,55 [5,[6][7][8][9][10][11][12][13][14]2] %. Beberapa penelitian lain yang pernah dipublikasi menunjukkan hasil rata-rata kadar HbA1c pasien charcot foot dengan diabetes melitus masuk dalam kategori diabetes atau ≥6,5%, contohnya pada penelitian Jansen dkk.…”

Section: Pembahasanunclassified

Profil Penderita Charcot Foot Dengan Diabetes Melitus Di Poli Orthopedi Rsup Prof. Dr. I.G.N.G Ngoerah Tahun 2020-2021

Sitranata,

Subawa,

Wiratnaya

et al. 2023

eum

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Latar belakang: Charcot foot merupakan proses inflamasi yang mengenai bagian sendi, tulang, dan jaringan lunak lainnya dan termasuk salah satu komplikasi dari diabetes melitus. Data profil penderita charcot foot dengan diabetes melitus masih belum ada hingga saat ini di Bali, termasuk di poli orthopedi RSUP Prof. Dr. I.G.N.G Ngoerah. Tujuan: Mengetahui distribusi profil penderita charcot foot dengan diabetes melitus di poli orthopedi RSUP Prof. Dr. I.G.N.G Ngoerah selama periode 2020-2021. Metode: Penelitian ini menggunakan metode deskriptif potong lintang dengan memakai data rekam medis penderita charcot foot dengan diabetes melitus di poli orthopedi RSUP Prof. Dr. I.G.N.G Ngoerah tahun 2020-2021 dengan sampel sebanyak 14 orang. Hasil penelitian: Didapatkan bahwa penderita charcot foot dengan diabetes melitus didominasi pada kelompok usia 40-44 tahun 28,6% dan berjenis kelamin perempuan 64,3% dengan status nutrisi obesitas 57,1%. Seluruh kasus menderita diabetes melitus tipe 2 dan kadar HbA1c ?6,5% sebanyak 78,6%. Kesimpulan: Profil penderita charcot foot dengan diabetes melitus di poli orthopedi RSUP Prof. Dr. I.G.N.G Ngoerah didominasi dari kelompok usia 40-44 tahun dan berjenis kelamin perempuan yang dimana seluruh kasus menderita diabetes melitus tipe 2 dengan status nutrisi obesitas dan kategori kadar HbA1c nya ?6,5%. Kata kunci : Profil, Charcot Foot, Diabetes Melitus

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Neuropathische Osteoarthropathie - Diagnostik und Therapiemöglichkeiten

Mehlhorn¹,

Lemperle²,

Pfahl³

et al. 2022

Orthop. Rheuma

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Prevalence, Characteristics, and Prognosis of Peripheral Arterial Disease in Patients With Diabetic Charcot Foot

Cited by 5 publications

References 34 publications

The Neuro-Ischaemic Charcot Foot: Prevalence, Characteristics and Severity of Peripheral Arterial Disease in Acute Charcot Neuro-Arthropathy

The Neuro-Ischaemic Charcot Foot: Prevalence, Characteristics and Severity of Peripheral Arterial Disease in Acute Charcot Neuro-Arthropathy

Profil Penderita Charcot Foot Dengan Diabetes Melitus Di Poli Orthopedi Rsup Prof. Dr. I.G.N.G Ngoerah Tahun 2020-2021

Neuropathische Osteoarthropathie - Diagnostik und Therapiemöglichkeiten

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