Prevalence, Clinical Characteristics, and Causes of Vision Loss in Children With Vogt-Koyanagi-Harada Disease in South India

Martin, Taliva D.; Rathinam, Sivakumar R.; Cunningham, Emmett T.

doi:10.1097/iae.0b013e3181c96a87

Cited by 35 publications

(21 citation statements)

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“… 6 , 7 In a study from a referral eye care center in South India, the prevalence is reported as 1.4%–3.5%. 8 VKH is seen more frequently in an adult population, and women are more frequently affected. 9 VKH disease usually manifests as four distinct clinical phases: prodromal, acute uveitic, convalescent, and chronic recurrent.…”

Section: Introductionmentioning

confidence: 99%

Clinical spectrum and management options in Vogt–Koyanagi–Harada disease

Lodhi

Reddy

Peram

2017

OPTH

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PurposeThe aim of this study was to describe the clinical features, treatment options, and visual outcome of Vogt–Koyanagi–Harada (VKH) disease patients over a 9-year period.MethodA retrospective chart analysis of 32 patients with VKH, from January 2007 to December 2015, at a tertiary care government medical college eye hospital in South India.ResultsA total of 32 patients were diagnosed with VKH. The mean age at diagnosis was 32.03±8.8 years. There were 24 patients (42 eyes) with acute VKH and eight patients (16 eyes) with recurrent/chronic VKH. The mean baseline best-corrected visual acuity on presentation in the acute VKH group was 5/60 (1.114±0.565) and at last follow-up it was 6/9 (0.225±0.157). Intravenous methyl prednisolone (IVMP) was administered for 3 days to all patients with acute and recurrent VKH, followed by posterior subtenon triamcinolone (40 mg/mL) and oral azathioprine.ConclusionVKH-related uveitis is more common in the female gender in this South Indian population. Posterior uveitis is the most common initial manifestation. Initial aggressive treatment with IVMP, peribulbar long-acting corticosteroids, and immunosuppressives, avoiding side effects of systemic steroids, gives a good visual outcome without recurrences. Cases of unilateral VKH, seen in six patients, are the initial manifestations in the natural course of the disease, which if managed aggressively at the acute stage prevents recurrence in the other eye.

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Section: Introductionmentioning

confidence: 99%

Clinical spectrum and management options in Vogt–Koyanagi–Harada disease

Lodhi

Reddy

Peram

2017

OPTH

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“…Little has been reported in the literature regarding the expected course or management of the integumentary features of VKH. Most publications are ophthalmology based and treatment is discussed in the context of managing the syndrome as a whole (2,4,5). The integumentary changes may be permanent, but there is a published case series suggesting that vitiligo and poliosis may be reversible with systemic immunotherapy (6).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Vitiligo Associated with Vogt–Koyanagi–Harada Disease

Bayer

Chiu

2016

Pediatric Dermatology

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“…Although women are more affected overall [2,3], a higher proportion of men may be affected in the Japanese population [4]. As with most types of uveitis, VKH is seen more frequently in the adult population, although the disease has been reported in children [5,6], the youngest of which was a 3-year-old girl [7].…”

Section: Epidemiologymentioning

confidence: 96%