Prevalence, clinical profiles, and outcome of hypertension in renal transplant recipients

Maasila, AT; Chandrabose, C Subash; Balasubramaniyan, T; Gopalakrishnanan, N; Dhanapriya, J; Dineshkumar, Thanigachalam; Sakthirajan, Ramanathan; Aravind, Shruthishree

doi:10.4103/ijot.ijot_37_18

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertension post-KTx is common among our KTRs with a rate of about 80% at 1-year post-KTx. Similar rates have been reported nationally [ 13 ] and internationally [ 4 , 21 , 22 ]. Although post-KTx hypertension negatively impacts the long-term graft and patient outcome [ 23 , 24 ], BP control remained suboptimal in many KTRs despite regular follow-up and the use of higher number of antihypertensive medications.…”

Section: Discussionsupporting

confidence: 88%

“…Among our KTRs, about one-third did not attain their BP targets at 12 months post-KTx. Comparable rates of uBP have also been reported in similar studies [ 21 , 25 ].…”

Section: Discussionsupporting

confidence: 82%

“…Among our KTRs, about one-third did not attain their BP targets at 12 months post-KTx. Comparable rates of uBP have also been reported in similar studies [21,25]. The overall BP regulation often improves as time passes after transplantation [17].…”

Section: Discussionsupporting

confidence: 70%

See 2 more Smart Citations

Incidence and Factors Associated with Uncontrolled Hypertension at 12 months after Kidney Transplantation in Saudi Arabia

Arabi¹,

Fawzy²,

Arabi³

et al. 2023

Kidney Blood Press Res

View full text Add to dashboard Cite

Introduction: Uncontrolled hypertension after kidney transplantation (KTx) is very common and is associated with significant morbidity. However, studies that assess its incidence and risk factors are limited and outdated in the Middle East. Methods: This is a single-center retrospective study of KTx recipients (KTRs) in our center between January 2017 and May 2020 with a 12-month follow-up period. The target of hypertension treatment during the time of this study was <140/90 mmHg, according to the published guidelines. We divided patients according to their blood pressure (BP) control at one year into two groups: controlled blood pressure (cBP) (<140/90) and uncontrolled blood pressure (uBP) ( ≥ 140/90). We studied the association between cBP and patients' demographics, baseline cardiovascular risk factors, and changes in their metabolic and cardiovascular profile during the first 12 months after KTx. Results: A total of 254 KTRs were included. 79.2% developed post-KTx hypertension, 74% were ≥ 30 years, 58% were men, and 80% were living-donor KTRs. The renal replacement modality among our patients/sample before KT was hemodialysis in 78.4%, peritoneal dialysis in 11.5%, and 10.1% underwent pre-emptive transplantation. At one year, 76 (29.9%) KTRs did not attain the target BP goal. Systolic BP decreased from baseline to 12 months by 13±24 mmHg in the cBP group and increased by 8.7±21 mmHg in the uBP group (p<0.001). Additionally, diastolic BP decreased by 8.5±16.9 mmHg in the cBP group and increased by 2.3±18.8 mmHg in the uBP group (p<0.001). Factors associated with uBP included age (47 vs 41 years, p=0.008) and diabetes mellitus (p=0.012). Contrarily, gender, dialysis vintage, preemptive transplantation, type of dialysis (hemodialysis vs peritoneal dialysis), type of transplant (living donor kidney transplant vs deceased donor kidney transplant), and smoking were not different among the two groups. There were no significant differences between the two groups in regard to creatinine change from baseline, rate of rejection, weight change, A1C change, new onset diabetes post-transplant, LDL change, PTH change from baseline, and persistent hyperthyroidism. However, higher BMI at 12 months was associated with a higher incidence of uBP (27.2±5.9 vs 29.2±5.4, p=0.013). Using multivariate analysis, we found that serum creatinine at 12 months was the only predictor of uBP (OR=1.005 (1-1.011), p=0.036). Conclusion: At one-year post renal transplantation, about one-third of KTRs had uBP despite multiple antihypertensive medications. SBP and DBP significantly trended upwards after transplantation in uBP patients, whereas SBP and DBP significantly trended downwards after transplantation in cBP patients. Further controlled, prospective studies in the Saudi population are needed to confirm these findings.

show abstract

Section: Discussionsupporting

confidence: 88%

“…Among our KTRs, about one-third did not attain their BP targets at 12 months post-KTx. Comparable rates of uBP have also been reported in similar studies [ 21 , 25 ].…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Incidence and Factors Associated with Uncontrolled Hypertension at 12 months after Kidney Transplantation in Saudi Arabia

Arabi¹,

Fawzy²,

Arabi³

et al. 2023

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

The Spectrum of Ocular Manifestations among Renal Transplant Recipients

Jain,

Sen,

Bhadauria

et al. 2024

Indian Journal of Transplantation

View full text Add to dashboard Cite

Purpose: The study aims to report various ocular manifestations among renal transplant recipients. Methods: The cross-sectional study was conducted on renal transplant patients, with at least 4 months of posttransplant duration, attending a nephrology clinic. A comprehensive ophthalmic evaluation was performed to record various ocular manifestations. The statistical association between ocular findings and pretransplant as well as posttransplant duration was assessed. Results: One hundred and twenty-three eyes of 62 patients, with a mean age of 37.6 ± 8.2 years and functional graft, were included in the study. Diabetic nephropathy was found to be the most common underlying cause of end-stage renal disease (ESRD) and renal transplant. Hypertensive retinopathy (37.4%) was found to be the most frequent ophthalmic manifestation, followed by diabetic retinopathy (24.39%), dry eye (22.76%), cataract (18.69%), and change in refractive error (17.89%). The occurrence of hypertensive retinopathy and refractive power change was found to be significantly associated with pretransplant dialysis duration. In contrast, concerning the posttransplant period, the frequency of all the major ocular manifestations, except the dry eye, was observed to be statistically significant. Conclusion: Patients with ESRD and renal transplant should be advised to undergo regular comprehensive eye examinations. Many ocular manifestations are preventable and/or treatable, thus interdisciplinary partnership between nephrologists and ophthalmologists is warranted to improve vision and quality of life in transplant recipients.

show abstract

Prevalence, clinical profiles, and outcome of hypertension in renal transplant recipients

Cited by 2 publications

References 0 publications

Incidence and Factors Associated with Uncontrolled Hypertension at 12 months after Kidney Transplantation in Saudi Arabia

Incidence and Factors Associated with Uncontrolled Hypertension at 12 months after Kidney Transplantation in Saudi Arabia

The Spectrum of Ocular Manifestations among Renal Transplant Recipients

Contact Info

Product

Resources

About