Prevalence, co-infection and antibiotic resistance of Escherichia Coli from blood and urine samples at a hospital in Jamaica

Abstract

Introduction: Escherichia coli (E. coli) is a very common uro-pathogen and pathogen of bloodstream infections (BSI) in Jamaica. The aim of this study was to examine this organism’s prevalence, determine co-infection rates and assess antibiotic resistance patterns.
 Methodology: In the absence of automated systems, data on all E. coli isolates identified at the University Hospital of the West Indies in Kingston, Jamaica during the first six months of 2008 and 2012 was collected and sorted. Data were analyzed using IBM SPSS Statistics version 20 for Windows.
 Results: A total of 1188 isolates (1072 from urine and 116 from blood) was analyzed. Patients with E. coli BSI were older than those with E. coli urinary tract infections (UTI) (55.3 years vs 42.4 years, p < 0.05) and both had a female predominance. Sensitivity profiles in 2012 for E. coli in blood and urine were highest for the carbapenems, Amikacin and Nitrofurantoin and lowest for the fluoroquinolones and Trimethoprim-sulfamethoxazole. Based on antimicrobial susceptibility patterns, Nitrofurantoin was identified as an appropriate choice for empiric therapy for UTI. Ten antibiotics were noted in this study to have developed statistically significant antibiotic resistance. Patients with E. coli BSI had a co-infection E. coli UTI rate of 39%.
 Conclusions: Resistance patterns change drastically in a few years making frequent antimicrobial susceptibility profiling necessary. Further studies would be beneficial in guiding management of these patients.

Genome Sequence Analysis and Characterization of Shiga Toxin 2 Production by Escherichia coli O157:H7 Strains Associated With a Laboratory Infection

“…The results also clearly support a simultaneous co-infection with laboratory-housed strains, which were the causative agents of previous O157:H7 outbreaks. Co-infections have been only observed rarely in STEC ( Rivas et al., 1993 ; Gilmour et al., 2007 ; Cheung et al., 2020 ), and the potential impact on disease manifestation by such mixed infections of strains featuring distinct genome and virulence traits has not been evaluated.…”

Prevalence and distribution of ampc beta-lactamase producing escherichia coli and klebsiella pneumoniae isolates obtained from urine samples at a tertiary care hospital in the caribbean

“…E. coli and Klebsiella species are very important Gram-negative uropathogens, significantly featured in samples collected from 2002 to 2004, 2008 and 2012 at the University Hospital of the West Indies (UHWI). They had levels of resistance to penicillins and cephalosporins greater than 30%, but negligible evidence of resistance to carbapenems ( Nicholson et al., 2009 ; Cheung et al., 2020 ). The aim of this study was to determine the prevalence and distribution of AmpC BL-producing uropathogens, specifically E. coli and K. pneumoniae at the UHWI, which is a major referral centre in the Caribbean.…”

Bacteriological Profile and Resistance of Escherichia coli to Beta-lactam for Patients Consulted at Douala Laquintinie Hospital

“…[7]. The preponderance of Escherichia coli in urine has been found by several authors, as presented by Cheung and colleagues in 2020 [8] and Wilson and collaborateurs [9]. Given the ubiquity of E. coli, it was also found in various other samples, such as pus (19.47%), data that is consistent with the work of Serraino and colleagues in 2018, who found E. coli at a frequency of 26.5% in pyogenic liver abscesses (PAA) [10].…”