Prevalence, correlates and recognition of depression in Chinese inpatients with cancer

Zhao, Libo; Li, Xiurong; Zhang, Zhiguo; Song, Chun‐Qing; Guo, Changyuan; Zhang, Yinghua; Zhang, Ying; Li, Li; Lu, Guilong; Zheng, Guodi; Wang, Kesong; Pei, Wei; Lv, Han

doi:10.1016/j.genhosppsych.2014.05.005

Cited by 35 publications

(53 citation statements)

References 40 publications

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“…Studies conducted in Asia ( n = 5) showed lower prevalence rates (7.4%, 95% CI = 4.3–12.5) compared with studies from other continents (Table ). Two studies in Asia identified only a 1% to 1.3% prevalence rate . Zhao et al reported that while the 1‐month prevalence of depressive disorder was 25% ( n = 119/460), only six patients were prescribed antidepressants.…”

Section: Resultsmentioning

confidence: 99%

“…For example, selective serotonin reuptake inhibitors may reduce the efficacy of tamoxifen, commonly prescribed in breast cancer treatment . Furthermore, research has raised the possibility that some patients may receive antidepressants unnecessarily, while those on prescriptions may not be optimally followed . Regular follow‐up of psychological status, adherence to treatment, potential drug–drug interactions or side effects is clearly important .…”

Section: Introductionmentioning

confidence: 99%

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A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

et al. 2016

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Background: Antidepressants are commonly used for the pharmacological treatment of depression. We aimed to summarise the prevalence of antidepressant prescription to cancer patients, and differences by study or patient characteristics.Methods: PubMed, Embase, Web of Science, Scopus and psychINFO were searched using keywords 'psychotropic', 'antidepressants', 'prescription' and 'cancer'. Prevalence of antidepressants, type, dose and follow-up of antidepressants and prescriber details were extracted.Results: Overall, 1537 articles between 1979 and February 2015 were found, 38 met the inclusion criteria and were reviewed according to PRISMA guidelines. The prevalence rate of prescribing antidepressants to cancer patients was 15.6% (95% CI = 13.3-18.3). Prescription was significantly less common in studies from Asia (7.4%; 95% CI = 4.3-12.5), more common in female (22.6%; 95% CI = 16.0-31.0) or breast cancer patients (22.6%; 95% CI = 16.0-30.9). Selective serotonin reuptake inhibitors were the most frequently prescribed antidepressants. General practitioners and psychiatrists, followed by oncologists, were identified as the major providers of antidepressant prescriptions to cancer patients. Few studies reported the exact dose, length of time drugs were prescribed for or follow-up regimens.Conclusions: There is considerable variation in the prescribing patterns of antidepressants across the world, with few studies reporting robust data on exact dose or follow-up regimens. Prospective studies that monitor antidepressant prescribing, including details of reasons for prescribing and the healthcare providers involved, dose, change in dose or type of medication and follow-up are needed to ascertain whether patients are being treated optimally and if side effects or drug-drug interactions are identified and managed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

et al. 2016

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“…Unlike people of Western countries, Chinese people often keep cancer a secret and those with cancer are reluctant to report their cancer-related emotional distress and suicidal feelings to medical professionals, due to stigma associated with cancer in the Chinese society; for example, some patients believe that cancer is a punishment from God for their past mistakes [12, 13]. Importantly, the subspecialty healthcare for addressing psychosocial problems of cancer patients, psychooncology services, have not been provided in most of the Chinese general hospitals and cancer specialty hospitals [13, 14]. Due to the lack of training in clinical psychiatry, Chinese physicians do not routinely screen their patients for mental health problems and suicidality [15, 16].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, even if some physicians of Chinese large hospitals are capable of recognizing depressed/suicidal individuals, most of them are usually too busy to pay adequate attention to patients’ emotional and suicidal issues. Results of a survey conducted among cancer inpatients of a university-affiliated hospital in Beijing, China, demonstrated a very high prevalence of major depression in Chinese cancer patients, but only 6.9% of the patients with major depression were detected or referred for psychiatric consultation [13]. Considering the strong association between untreated major depression and suicidality [17], it is very likely that suicidal problems in cancer patients are prevalent but seriously neglected in China's hospitals.…”

Section: Introductionmentioning

confidence: 99%

Suicidal ideation among Chinese cancer inpatients of general hospitals: prevalence and correlates

Zhong

et al. 2017

Oncotarget

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Cancer patients are at high risk for suicide, particularly when they are informed about the cancer diagnosis or hospitalized for cancer treatment. Therefore, oncology healthcare settings such as large general hospitals in China, may represent an ideal setting to identify and treat suicidality in cancer patients. However, the clinical epidemiology of suicidality of Chinese cancer patients remains largely unknown. This study examined the prevalence and correlates of suicidal ideation among Chinese cancer inpatients of large general hospitals. A total of 517 cancer inpatients were consecutively recruited from two tertiary general hospitals of a metropolitan city in northern China, and administered with standardized questionnaires to collect data on sociodemographics, mental health, and cancer-related clinical characteristics. Suicidal ideation and mental health were measured with a single self-report question “In the past month, did you think about ending your life?” and Hospital Anxiety and Depression Scale, respectively. The one-month prevalence of suicidal ideation was 15.3% in Chinese cancer inpatients. In multivariable Logistic regression, depression, anxiety, moderate-to-severe pain, metastatic cancer, poor performance status, surgery, and palliative care were significantly associated with suicidal ideation. Cancer inpatients of large Chinese general hospitals have high prevalence of suicidal ideation and therefore potentially at high risk for suicide. Suicide prevention efforts for cancer inpatients should include periodic evaluation of suicidality, effective pain management, psychooncological supports, and, when necessary, psychiatric treatment and crisis intervention.

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“…The number of studies about new treatment agents and combinations in acute leukemia are increasing, yet there are limited studies about anxiety and depression. There are a number of research focused on anxiety and depression in solid tumors, however, the same interest is not observed in the field of hematologic malignancies [17,18]. Psychological and medical supports at the time of diagnosis and during treatment are essential to revitalize the patient's desire to live and increase the adherence to treatment.…”

Section: Discussionmentioning

confidence: 99%

Are We Aware of Anxiety and Depression in Patients with Newly Diagnosed Acute Leukemia?

Doğu¹,

Eren²,

Yılmaz³

et al. 2017

J Gen Pract

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Objectives: We aimed to assess the status of anxiety and depression in newly diagnosed acute leukemia patients. Material and Method:In this prospective, observational, cross-sectional study, we aimed to assess the risks of anxiety and depression in newly diagnosed acute leukemia patients who were admitted to hematology clinic of Ministry of Health İstanbul Training and Research Hospital in 2016.Results: A total of 21 patients including 13 (61.9%) patients with Acute Myeloid Leukemia (AML) and 8 (38.1%) patients with Acute Lymphoblastic Leukemia (ALL) were evaluated in the study. The median age of the patients was 45 years (range: 21-69) and the number of female patients were 11 (52.4%). Only eight (38.1%) patients, who were diagnosed with AML in five (38.5%) patients and ALL in three (37.5%) patients, have revealed to have anxiety. The anxiety rates were 45.5% (n:5) in the female patients and only 30% (n:3) in the male patients. The difference was not statistically significant (p>0.05). Depression was recorded in 17 (81%) patients and the rates of depression were 84.6% (n:11) in AML patients, 75% (n:6) in ALL patients, 81.8% (n:9) in the female, and 80% (n:8) in the male patients. Conclusion:The assessment of anxiety and depression in patients with acute leukemia from the admission to hospital is substantial for the adherence to treatment. Both are distinctively more common in those patients and trigger each other causing a vicious circle. A professional support to improve their psychological status should be provided during the treatment of these patients.

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Prevalence, correlates and recognition of depression in Chinese inpatients with cancer

Cited by 35 publications

References 40 publications

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

Suicidal ideation among Chinese cancer inpatients of general hospitals: prevalence and correlates

Are We Aware of Anxiety and Depression in Patients with Newly Diagnosed Acute Leukemia?

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