Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Drug Abuse and Dependence in the United States

Compton, Wilson M.; Thomas, Yonette F.; Stinson, Frederick S.; Grant, Bridget F.

doi:10.1001/archpsyc.64.5.566

Cited by 1,176 publications

(1,027 citation statements)

References 77 publications

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“…Among the most concerning comorbidities in juvenile onset BPD is the link with cigarette smoking and substance use disorders (SUD; including drug or alcohol abuse or dependence). Recent epidemiological data suggests that SUD occurs in up to 15% of the adult population (Kessler, et al, 2005) with a one year prevalence of 1.4% and 0.6% for drug abuse and dependence (Compton, et al, 2007); and 4.7% and 3.8% for alcohol abuse and dependence (Grant, et al, 2004). These data also show the frequent onset of both alcohol and drug use disorders during adolescence (Compton, et al, 2007, Grant, et al, 2004, Kessler, et al, 2005.…”

Section: Introductionmentioning

confidence: 89%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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Section: Introductionmentioning

confidence: 89%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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“…We assessed alcohol and nicotine dependence as outcomes without a corresponding abuse diagnosis; for alcohol, abuse has little relationship with personality disorders 1, 27, 29 , and for nicotine, no abuse diagnosis exists in DSM-IV. We assessed cannabis use disorders because cannabis is the most widely used illicit drug, and because drug abuse and dependence are both associated with personality disorders in the NESARC 4,28-30 . We focused on these three substances because they are the most common in the general population.…”

Section: Methodsmentioning

confidence: 99%

“…Alcohol, nicotine and drug use disorders are highly prevalent 1-3 , comorbid with other mental disorders 1, 2, 4, 5 , and associated with considerable health, economic and social burdens. The chronic nature of substance use disorders (SUD) seen in alcohol and drug treatment settings 6, 7 continues to present challenges to clinicians and researchers.…”

Section: Introductionmentioning

confidence: 99%

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Hasin

Fenton

Skodol

et al. 2011

Arch Gen Psychiatry

185

100

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Context Little is known about the role of a broad range of personality disorders in the course of substance use disorder (SUD), and whether these differ by substance. The existing literature focuses mostly on antisocial personality disorder and does not come to clear conclusions. Objective To determine the association between the ten DSM-IV personality disorders and the persistence of common SUDs in a 3-year prospective study of a national sample. Design Data were drawn from participants in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) who had alcohol dependence (N=1,172), cannabis use disorder (N=454) or nicotine dependence (N=4,017) at baseline and who were re-interviewed three years later. Control variables included demographic characteristics, family history of substance disorders, baseline Axis I disorders and treatment status, and prior SUD duration. Main outcome measure Persistent SUD, defined as meeting full criteria for the relevant SUD throughout the 3-year follow-up period. Results Persistent SUD was found among 30.1% of participants with alcohol dependence, 30.8% with cannabis use disorder, and 56.6% with nicotine dependence at baseline. Axis I disorders did not have strong or consistent associations with persistent SUD. In contrast, antisocial personality disorder was significantly associated with persistent alcohol, cannabis and nicotine use disorders (adjusted odds ratios: 2.46-3.51), as was borderline personality disorder (adjusted odds ratios: 2.04-2.78) and schizotypal personality disorder (adjusted odds ratios: 1.65-5.90). Narcissistic, schizoid, and obsessive-compulsive personality disorders were less consistently associated with SUD persistence. Conclusions The consistent findings on the association of antisocial, borderline and schizotypal personality disorders with persistent SUD indicates the importance of these personality disorders in understanding the course of SUD. Future studies should examine dimensional representations of personality disorders and the role of specific components of these disorders, biological and environmental contributors to these relationships, and potential applications of these findings to treatment development.

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“…This state-of-the-art instrument was specifically developed to assess current and lifetime drug and alcohol abuse and dependence. Fourth, perhaps because the AUDADIS measure of family history was designed to tap observable manifestations of alcohol and drug use disorders, the prevalence of family history of alcohol and drug problems in first degree relatives was similar to prevalences of alcohol and drug use disorders in the U.S. general population as a whole (Compton et al, 2007;Hasin et al, 2007). This suggests that sensitivity was good in the AUDADIS family history measure.…”

Section: Discussionmentioning

confidence: 97%

Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies

Heiman

Ogburn²,

Gorroochurn

et al. 2008

Drug and Alcohol Dependence

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Some twin studies suggest that substance initiation and dependence are part of a complex, two-stage process and that some genetic influences are stage-specific, acting on either the transition from abstinence to initiation, or on the transition from use to dependence. However, questions remain about the two-stage model, especially for illicit drugs. Using a familial aggregation design, we tested the hypothesized two-stage model of dependence on illicit substances and alcohol in a large, nationally representative sample. Family history of drug or alcohol problems is significantly associated with initiation that does not progress to dependence (i.e., conditional initiation). Furthermore, family history of drug or alcohol problems is significantly associated with dependence even after conditioning on factors influencing initiation (i.e., conditional dependence). These results suggest that substance initiation and dependence involve at least partially distinct familial factors. The possibility that different genetic factors affect initiation and dependence has important implications for control group selection in case-control genetic association studies, and may explain some inconsistent results for drug dependence. If some genetic factors are stage-specific (i.e., not common across initiation and dependence), inclusion of abstainers in the control group may mix the genetic effects for initiation with those for transition to dependence, providing unclear results. Depending on the specific question about the nature of the genetic effect (whether on initiation, on dependence, or both), investigators designing case-control genetic association studies should carefully consider inclusion and exclusion criteria of the control group.

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Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Drug Abuse and Dependence in the United States

Cited by 1,176 publications

References 77 publications

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies

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