Prévalence de la carence martiale dans une population de patients insuffisants rénaux chroniques non dialysés : étude nationale multicentrique observationnelle CARENFER

Choukroun, Gabriel; Kazes, Isabelle; Dantal, Jacques; Vabret, Elsa; Couzi, Lionel; Meur, Yann Le; Trochu, Jean‐Noël; Cacoub, P.

doi:10.1016/j.nephro.2021.12.003

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Indeed, in older patients, the underlying cause of ID is often multifactorial because several chronic comorbidities are frequently present. In the other CARENFER studies, high ID prevalence was reported in patients with cancer (57.9%) [ 6 ], heart failure (49.6%) [ 7 ], inflammatory bowel diseases (23.7%) [ 9 ] CKD (47.1%) [ 8 ] or preoperatively in patients undergoing major elective surgery (47.0%) [ 36 ]. By using a common definition of ID (serum ferritin < 100 μg/L and/or TSAT < 20%), the prevalence rates for the different chronic conditions were 58.1% in cancer, 62.8% in heart failure, 61.2% in inflammatory bowel disease and 47.1% in CKD [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study

Fougère,

Puisieux,

Chevalet

et al. 2024

BMC Geriatr

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Background Iron deficiency (ID) is often associated with other comorbidities in older patients and is a factor of morbimortality. However, the prevalence of ID remains poorly documented in this population. Methods The CARENFER PA study was a French multicenter cross-sectional study whose objective was to evaluate ID in patients (> 75 years) admitted to a geriatric unit. The primary endpoint was the ID prevalence defined as: serum ferritin < 100 µg/L and/or transferrin saturation coefficient (TSAT) < 20%. The Short Physical Performance Battery (SPPB) test was used to identify older patients at high risk of adverse events (e.g., disability, falls, hospitalization, death). Results A total of 888 patients (mean age, 85.2 years; women, 63.5%) from 16 French centers were included from October 2022 to December 2022. The prevalence of ID was 57.6% (95% CI, 54.3–60.9) in the cohort of older patients (62.6% in anemic and 53.3% in non-anemic patients; p = 0.0062). ID prevalence increased significantly with the presence of more than three comorbidities (65.6% vs. 55.9%; p = 0.0274), CRP ≥ 12 mg/L (73.0% vs. 49.3%; p < 0.001) and treatment that may influence ID/anemia (60.5% vs. 49.6%; p = 0.0042). In multivariate analysis, only CRP ≥ 12 mg/L was an independent predictive factor of ID (odds ratio, 2.78; 95% CI, 1.92–4.08; p < 0.001). SPPB scores were low (0–6) in 60.5% of patients with ID versus 48.6% of patients without ID (p = 0.0076). Conclusion More than half of older patients had ID, including non-anemic patients. ID was associated with the presence of inflammation and a low SPPB score. Trial registration NCT05514951.

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Section: Discussionmentioning

confidence: 99%

Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study

Fougère,

Puisieux,

Chevalet

et al. 2024

BMC Geriatr

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Section: Discussionmentioning

confidence: 99%

“…Comparable prevalence has been reported in the other prospective French CARENFER studies using the same definition of iron deficiency: 58.1% in cancer, 62.8% in chronic heart failure, 61.2% in intestinal bowel disorder, and 47.1% in chronic kidney disease. 16,[20][21][22][23] Iron deficiency is often present in the absence of anemia, which is the ultimate stage of iron deficiency. Munoz et al 1 reported iron deficiency in 68.7% of nonanemic and 87% of anemic patients undergoing cardiac surgery.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Iron Deficiency in Patients Scheduled for Major Elective Surgeries: A French Prospective Multicenter Cross-Sectional Study

Capdevila

Lasocki

Duchalais

et al. 2023

Anesthesia &Amp; Analgesia

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BACKGROUND: The management of perioperative iron deficiency is a component of the concept of patient blood management. The objective of this study was to update French data on the prevalence of iron deficiency in patients scheduled for major surgery. METHODS: The CARENFER PBM study was a prospective cross-sectional study in 46 centers specialized in orthopedic, cardiac, urologic/abdominal, or gynecological surgery. The primary end point was the prevalence of iron deficiency at the time of surgery (D-1/D0) defined as serum ferritin <100 µg/L and/or transferrin saturation (TSAT) <20%. RESULTS: A total of 1494 patients (mean age, 65.7 years; women, 49.3%) were included from July 20, 2021 to January 3, 2022. The prevalence of iron deficiency in the 1494 patients at D-1/D0 was 47.0% (95% confidence interval [CI], 44.5–49.5). At 30 days after surgery, the prevalence of iron deficiency was 45.0% (95% CI, 42.0–48.0) in the 1085 patients with available data. The percentage of patients with anemia and/or iron deficiency increased from 53.6% at D-1/D0 to 71.3% at D30 (P < .0001), mainly due to the increase of patients with both anemia and iron deficiency (from 12.2% at D-1/D0 to 32.4% at D30; P < .0001). However, a treatment of anemia and/or iron deficiency was administered preoperatively to only 7.7% of patients and postoperatively to 21.7% (intravenous iron, 14.2%). CONCLUSIONS: Iron deficiency was present in half of patients scheduled for major surgery. However, few treatments to correct iron deficiency were implemented preoperatively or postoperatively. There is an urgent need for action to improve these outcomes, including better patient blood management.

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Prise en charge de la carence martiale au cours de la maladie rénale chronique : mise au point et proposition d’un algorithme

Guibergia

Brazier

Choukroun

2022

Néphrologie & Thérapeutique

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Prévalence de la carence martiale dans une population de patients insuffisants rénaux chroniques non dialysés : étude nationale multicentrique observationnelle CARENFER

Cited by 3 publications

References 14 publications

Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study

Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study

Perioperative Iron Deficiency in Patients Scheduled for Major Elective Surgeries: A French Prospective Multicenter Cross-Sectional Study

Prise en charge de la carence martiale au cours de la maladie rénale chronique : mise au point et proposition d’un algorithme

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