Prevalence, determinants and genetic diversity of hepatitis C virus in the multi-ethnic population living in Suriname

Donald-Ottevanger, M. Sigrid Mac; Vreden, Stephen; Helm, Jürgen; Laar, Thijs van de; Molenkamp, Richard; Dams, Els; Roosblad, Jimmy; Codrington, John; Hindori-Mohangoo, Ashna D.; Prins, Maria

doi:10.1016/j.virol.2016.07.001

Cited by 8 publications

(11 citation statements)

References 20 publications

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“…37 For migrants from Ghana and Suriname, we expected a higher prevalence based on previous studies in the country of origin and/or the Netherlands. [37][38][39][40] The low HCV infection prevalence found in our study may be due to the same reasons as mentioned for HBV infection. Alternatively, for some countries of origin, there are vast differences in HCV prevalence across regions (Ghana 38 ) and in sub-ethnicities (Javanese-Surinamese 40 ), which might not be reflected in our study.…”

Section: Research Articlesupporting

confidence: 57%

Hepatitis B and C screening needs among different ethnic groups: A population-based study in Amsterdam, the Netherlands

et al. 2019

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Background & Aims: Data on the prevalence of chronic hepatitis B (HBV) and hepatitis C (HCV) virus infections, including the proportion of individuals aware of infection, are scarce among migrants living in Europe. We estimated the prevalence of past and present HBV and HCV infection, along with their determinants and peoples' awareness of infection status, among different groups of first-generation migrants and Dutch-origin residents of Amsterdam.Methods: Cross-sectional data of 998 Surinamese (mostly South-Asian and African-Surinamese), 500 Ghanaian, 497 Turkish, 498 Moroccan and 500 Dutch-origin participants from the observational population-based HELIUS study were used. Blood samples of participants were tested for HBV and HCV infection. Infection awareness was determined using records from participants' general practitioners.Results: Age-and gender-adjusted chronic HBV prevalence was highest among Ghanaian participants (5.4%), followed by Turkish (4.1%), African-Surinamese (1.9%), Moroccan (1.2%), South-Asian Surinamese (0.9%) and Dutch (0.4%) participants. A total of 58.1% of the cases were aware of their infection. In multinomial logistic regression analyses, Ghanaian (adjusted odds ratio [aOR] 42.23; 95% confidence interval [CI] 9.29-192.01), African-Surinamese (aOR 6.16; 95% CI 1.27-29.79), and Turkish (aOR 13.44; 95% CI 2.94-61.39) participants were at increased risk of chronic HBV infection compared with those of Dutch origin. Older participants were also at increased risk (aOR 1.02 per year; 95% CI 1.00-1.05), whereas women were at lower risk (aOR 0.49; 95% CI 0.29-0.83). HCV prevalence was 0.4% (95% CI 0.1-1.3%) among Dutch and African-Surinamese and 0% (95% CI 0.0-0.5%) for each of the other groups; all cases with follow-up data were aware of their infection. Conclusions:Ghanaian, Turkish and African-Surinamese first-generation migrants are at increased risk of chronic HBV infection and many are unaware of their infection, whereas HCV prevalence was low among all ethnic groups. Screening campaigns are urgently warranted and need to consider specific ethnic groups.

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Section: Research Articlesupporting

confidence: 57%

Hepatitis B and C screening needs among different ethnic groups: A population-based study in Amsterdam, the Netherlands

et al. 2019

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“…The study showed that among the anti-HCV-positive cases, 23.3% had tattoos and piercing as a risk factor, as in the present study, although there is no representation regarding the decade of birth 17 . A survey of 2,128 individuals in Suriname found an association between HCV positivity and male sex, advanced age, Javanese ethnicity, and presence of tattoos 22 . In a study in Rio de Janeiro, Brazil, with 4,897 individuals tested for the presence of HCV, there were 1,180 HCV RNA-positive cases, and a significant association between RNA positivity and drug use but not with tattoos and piercings was found 23 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological survey of hepatitis C in a region considered to have high prevalence: the state of Minas Gerais, Brazil

Gomide

Melo

Santos

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: The prevalence of hepatitis C virus (HCV) infection is affected by demographic, virological, clinical, and lifestylerelated factors and varies in different regions in Brazil or worldwide. The present study aimed to clarify the epidemiological patterns of HCV infection in the interior region of Brazil. Methods: This study was conducted in the Southern Triangle Macro-region of the state of Minas Gerais, Brazil, according to the guidelines of the National Program for the Prevention and Control of Viral Hepatitis. The participants answered a structured questionnaire on social and epidemiological factors.Immunochromatographic rapid tests were used for the qualitative detection of antibodies against HCV in whole blood (Alere HCV® Code 02FK10) in adult subjects by a free-standing method. Results: Of 24,085 tested individuals, 184 (0.76%) were anti-HCV positive. The majority of anti-HCV-positive individuals were born between 1951 and 1980 (n=146 [79.3%]), with 68 women and 116 men. Identified risk factors included syringe and/or needle sharing (p = 0.003), being in prison (p = 0.004), and having tattoos or piercings (p = 0.005) and were significantly associated with the decade of birth. Conclusions: The study shows the importance of testing populations at risk for HCV infection, including incarcerated individuals, those with tattoos or piercings, those who share or have shared syringes or needles, and those in high-risk birth cohorts (1950s, 1960s, and 1970s) in the Southern Triangle Macro-region.

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“…We used samples and data from a previous study conducted in Suriname, 14 in which the epidemiology and genotypic spread of hepatitis C virus (HCV) were evaluated. Details have been described elsewhere.…”

Section: Methodsmentioning

confidence: 99%

“…Javanese, Hindustani, tribal, Creole, mixed/other); however, all individuals included in the parent study who were from the indigenous group were sampled (as the sample size was much smaller compared with all the other ethnic groups). 14 Sera of selected individuals were tested for total anti-HAV antibodies using the enzyme-linked immunoassay (DiaSorin Anti-HAV Immunoassay Kit, Saluggia, Italy), and anti-HEV antibodies by means of an enzyme-linked immunosorbent assay-based assay (Wantai Hepatitis E Total Antibody Kit, Beijing, China).…”

Section: Methodsmentioning

confidence: 99%

Ethnic differences in hepatitis A and E virus seroprevalence in patients attending the Emergency Department, Paramaribo, Suriname

Donald-Ottevanger

Prins

Dissel

et al. 2022

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Hepatitis A virus (HAV) and hepatitis E virus (HEV) have enteric modes of transmission and are common causes of acute hepatitis in low- and middle-income countries. HEV is also characterised as a zoonotic infection and is prevalent in high-income countries. Data on HAV and HEV prevalence in Suriname, a middle-income country in South America, are scarce. Methods Serum samples of 944 and 949 randomly selected patients attending the Emergency Department at the Academic Hospital of Paramaribo, the capital of Suriname, were analysed for anti-HAV antibodies (anti-HAV) and anti-HEV antibodies (anti-HEV), respectively. Determinants of anti-HAV and anti-HEV positive serology were evaluated using multivariable logistic regression. Results Anti-HAV prevalence was 58.3% (95% CI 55.4 to 61.4%) and higher prevalence was independently associated with belonging to the Tribal or Indigenous population and older age. Anti-HEV prevalence was 3.7% (95% CI 2.6 to 5.0%) and higher prevalence was associated with Tribal and Creole ethnicity and older age. Conclusions In Suriname, exposure to HAV is consistent with a very low endemic country and exposure to HEV was rare. Both viruses were more prevalent in specific ethnic groups. As anti-HAVantibodies were less frequently found in younger individuals, they could be susceptible to potential HAV outbreaks and might require HAV vaccination.

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Prevalence, determinants and genetic diversity of hepatitis C virus in the multi-ethnic population living in Suriname

Cited by 8 publications

References 20 publications

Hepatitis B and C screening needs among different ethnic groups: A population-based study in Amsterdam, the Netherlands

Hepatitis B and C screening needs among different ethnic groups: A population-based study in Amsterdam, the Netherlands

Epidemiological survey of hepatitis C in a region considered to have high prevalence: the state of Minas Gerais, Brazil

Ethnic differences in hepatitis A and E virus seroprevalence in patients attending the Emergency Department, Paramaribo, Suriname

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