Prevalence, Emergence, and Factors Associated with a Viral Papillomatosis and Carcinomatosis Syndrome in Wild, Reintroduced, and Captive Western Barred Bandicoots (Perameles bougainville)

Woolford, Lucy; Bennett, Mark D.; Sims, Colleen; Thomas, Neil; Friend, J. Anthony; Nicholls, P.K.; Warren, K.; O’Hara, A.J.

doi:10.1007/s10393-009-0258-5

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…The possible association between reduced genetic diversity and cancer prevalence is further supported by the high prevalence of cancer observed in both captive and wild western barred bandicoot (Perameles bougainville), a highly endangered Australian marsupial once widespread across western and southern Australia but now restricted to two small islands off the Western Australian coast (Woolford et al, 2008(Woolford et al, , 2009. Captive breeding of this species has been severely hampered by debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis, associated with infection of papillomatosis carcinomatosis virus type 1 (BPCV1) (Woolford et al, 2008(Woolford et al, , 2009.…”

Section: Mammalsmentioning

confidence: 98%

Cancer Prevalence and Etiology in Wild and Captive Animals

Madsen

Arnal

Vittecoq

et al. 2017

Ecology and Evolution of Cancer

106

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Section: Mammalsmentioning

confidence: 98%

Cancer Prevalence and Etiology in Wild and Captive Animals

Madsen

Arnal

Vittecoq

et al. 2017

Ecology and Evolution of Cancer

106

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“…PCR detection and in situ hybridization analyses demonstrated that the virus is present in the majority of papillomatous and carcinomatous lesions tested (6,45,46). Because the western barred bandicoot is an endangered species, obtaining tissue explants from infected animals is a challenge.…”

Section: Bpcv1-mir-b1 Is Expressed In Vivomentioning

confidence: 99%

“…BPCV1 infects western barred bandicoots (Perameles bougainville), an endangered species whose only remaining natural range is on the Bernier and Dorre Islands in Western Australia. Infection with BPCV1 is associated with an often fatal papillomatosis and carcinomatosis disease that is endemic among the western barred bandicoots and has therefore hindered repopulation efforts (45). BPCV2 is a related virus that was isolated from a papillomatous lesion from a southern brown bandicoot (Isoodon obesulus) (7).…”

mentioning

confidence: 99%

Insights into Polyomaviridae MicroRNA Function Derived from Study of the Bandicoot Papillomatosis Carcinomatosis Viruses

Chen

Kincaid

Seo

et al. 2011

J Virol

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Several different members of the Polyomaviridae, including some human pathogens, encode microRNAs (miRNAs) that lie antisense with respect to the early gene products, the tumor (T) antigens. These miRNAs negatively regulate T antigen expression by directing small interfering RNA (siRNA)-like cleavage of the early transcripts. miRNA mutant viruses of some members of the Polyomaviridae express increased levels of early proteins during lytic infection. However, the importance of miRNA-mediated negative regulation of the T antigens remains uncertain. Bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1) is associated with papillomas and carcinomas in the endangered marsupial the western barred bandicoot (Perameles bougainville). BPCV1 is the founding member of a new group of viruses that remarkably share distinct properties in common with both the polyomavirus and papillomavirus families. Here, we show that BPCV1 encodes, in the same orientation as the papillomavirus-like transcripts, a miRNA located within a long noncoding region (NCR) of the genome. Furthermore, this NCR serves the function of both promoter and template for the primary transcript that gives rise to the miRNA. Unlike the polyomavirus miRNAs, the BPCV1 miRNA is not encoded antisense to the T antigen transcripts but rather lies in a separate, proximal region of the genome. We have mapped the 3 untranslated region (UTR) of the BPCV1 large T antigen early transcript and identified a functional miRNA target site that is imperfectly complementary to the BPCV1 miRNA. Chimeric reporters containing the entire BPCV1 T antigen 3 UTR undergo negative regulation when coexpressed with the BPCV1 miRNA. Notably, the degree of negative regulation observed is equivalent to that of an identical reporter that is engineered to bind to the BPCV1 miRNA with perfect complementarity. We also show that this miRNA and this novel mode of early gene regulation are conserved with the related BPCV2. Finally, papillomatous lesions from a western barred bandicoot express readily detectable levels of this miRNA, stressing its likely importance in vivo. Combined, the alternative mechanisms of negative regulation of T antigen expression between the BPCVs and the polyomaviruses support the importance of miRNA-mediated autoregulation in the life cycles of some divergent polyomaviruses and polyomavirus-like viruses.MicroRNAs (miRNAs) are small, approximately 22-nucleotide (nt) regulatory RNA molecules that have been shown to play an important role in numerous fields, including virology and immunology (reviewed in references 3, 9, 37, and 43).

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“…Characterisation of genes involved in the immune response will lead to a better understanding of the response of marsupials to disease, particularly with diseases such as DFTD in devils [32], a viral papillomatosis and carcinomatosis syndrome in western barred bandicoots ( Perameles bougainville ) [34], and Chlamydia in koalas ( Phascolarctos cinereus ) [35], threatening the survival of these species (or at least populations of these species). In addition, some of the unique features of marsupials have made discerning the evolution of immune genes of particular interest.…”

Section: Immune Genesmentioning

confidence: 99%

“…This increases the susceptibility of the health of a population if a novel disease is encountered [34, 74, 75]. Given that pathogens are known to drive genetic diversity at immune gene loci in their hosts, it would seem essential to assess the genetic diversity of immune genes.…”

Section: Immune Genesmentioning

confidence: 99%

Marsupial Genome Sequences: Providing Insight into Evolution and Disease

Deakin

2012

Scientifica

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Marsupials (metatherians), with their position in vertebrate phylogeny and their unique biological features, have been studied for many years by a dedicated group of researchers, but it has only been since the sequencing of the first marsupial genome that their value has been more widely recognised. We now have genome sequences for three distantly related marsupial species (the grey short-tailed opossum, the tammar wallaby, and Tasmanian devil), with the promise of many more genomes to be sequenced in the near future, making this a particularly exciting time in marsupial genomics. The emergence of a transmissible cancer, which is obliterating the Tasmanian devil population, has increased the importance of obtaining and analysing marsupial genome sequence for understanding such diseases as well as for conservation efforts. In addition, these genome sequences have facilitated studies aimed at answering questions regarding gene and genome evolution and provided insight into the evolution of epigenetic mechanisms. Here I highlight the major advances in our understanding of evolution and disease, facilitated by marsupial genome projects, and speculate on the future contributions to be made by such sequences.

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Prevalence, Emergence, and Factors Associated with a Viral Papillomatosis and Carcinomatosis Syndrome in Wild, Reintroduced, and Captive Western Barred Bandicoots (Perameles bougainville)

Cited by 12 publications

References 20 publications

Cancer Prevalence and Etiology in Wild and Captive Animals

Cancer Prevalence and Etiology in Wild and Captive Animals

Insights into Polyomaviridae MicroRNA Function Derived from Study of the Bandicoot Papillomatosis Carcinomatosis Viruses

Marsupial Genome Sequences: Providing Insight into Evolution and Disease

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