Prévalence et aspects cliniques des mycoses superficielles chez le diabétique tunisien en milieu hospitalier

Bouguerra, R; Essais, Olfa; Sebai, Nadia Ezzine; Salem, L. Ben; Amari, H.; Kammoun, Mohamed; Chaker, E.; Zidi, B.; Slama, C. Ben

doi:10.1016/j.medmal.2004.03.004

Cited by 14 publications

(16 citation statements)

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“…This prevalence is much higher than the 30% reported by Bouquerra et al [12], in Tunisia and other researchers in countries where similar studies have been conducted [6, 13, 14]. This prevalence is nevertheless similar to the 50.4% obtained by Gerami et al [15], and the 55% obtained by Sürücüoğlu et al [16].…”

Section: Discussionsupporting

confidence: 78%

Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns

et al. 2016

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BackgroundOnychomycosis is an infection of the nail unit by a fungus. This is a very common infection amongst diabetics. Its occurrence among diabetics in Fako division is unknown. In this study we provide information on the characteristics of onychomycosis in diabetics in Fako division, Cameroon.MethodsA cross-sectional descriptive and analytical hospital-based study was conducted in two diabetic clinics in the Buea and Limbe regional hospitals. We recruited 152 consenting diabetics into the study. Demographic, behavioural, and clinical data of patients were obtained through the use of structured questionnaires. Toenail, finger nail, skin scrapings and nail clippings were collected from participants, KOH mounts were prepared and observed under the microscope and cultured on Sabouraud Dextrose Agar supplemented with chloramphenicol to isolate causative fungi. Identification of isolates was done to species level using the cello tape flag method and slide culture. The presence of a dermatophyte by either microscopy or culture or both methods was considered positive for onychomycosis. Antifungal susceptibility testing was carried out using selected antifungals by the Kirby–Bauer disk diffusion method on Sabouraud Dextrose Agar.ResultsClinical onychomycosis was found in 77 of the 152 diabetics tested giving a prevalence of 50.7% (95% CI 42.4–58.9) in diabetics in Fako. No socio-demographic or clinical factor studied was significantly associated with onychomycosis. Trichophyton rubrum was the most common isolate (62%). Other isolates included Trichophyton metagraphyte (22%) and Trichophyton tonsurans (16%). Dermatophytes were sensitive to miconazole (66%), amphotericin B (19%) and ketoconazole (14%).ConclusionOnychomycosis is common in diabetics in Fako signifying the need for regular screening by either microscopy or culture. Infected nails could be treated with miconazole.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2302-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 78%

Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns

et al. 2016

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“…En Tunisie, les études cliniques dans le milieu hospitalier se sont intéressées aux infections cutanées (Bouguerra et al, 2004 ;Ben Salem et al, 2011). Cependant, l'éventuelle implication du contexte climatique dans l'explication d'une telle situation épidémiologique est peu étudiée.…”

Section: Echogéo 38 | 2016unclassified

Bioclimatologie des infections cutanées mycosiques à Sfax (Centre-Est de la Tunisie)

Jarraya¹

2016

echogeo

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Les infections mycosiques constituent un problème majeur de santé publique à Sfax (Centre-Est de la Tunisie), puisqu’elles affectent une population vulnérable. L’étude de la répartition temporelle des consultations pour mycose durant la période 2009-2013 a permis de détecter un pic printanier et un pic automnal. Les analyses montrent une relation entre d’une part, les caractéristiques climatiques (température et taux d’humidité relative (thermo-hygrométrie)), qui instaurent un certain inconfort et d’autre part, l’augmentation des cas d’infections mycosiques dans la population étudiée.

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“…In 2017, the global prevalence of adultonset diabetes was nearly 425 million [2]. It is currently recognized that diabetes mellitus is both a factor in promoting and aggravating mucocutaneous lesions [3]. Although these infections are generally benign, they can have a major impact on the vital and functional prognosis, as well as on the quality of life, of diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and mycological profile of superficial mycoses in diabetic patient

Fatiha Bousnina,

Oumaima Nassiri,

Oumaima kharkhach

et al. 2024

World J. Bio. Pharm. Health Sci.

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Introduction: Superficial mycoses, especially those of nails, scalp and skin, are very common in various countries. The presence of specific terrain, as well as other factors, can affect the prevalence of these. In this sense, diabetic patients are more susceptible to infections especially fungal infections because of changes in the immune system and macro and microvascular changes. The objective of our study was to determine the epidemiological and mycological profile of superficial mycoses in diabetic patients at the Mohammed VI Hospital in Oujda (Morocco). Material and methods: This is a retrospective, observational and descriptive study spread over 34 months, from January 2021 to October 2023 at the Parasitology-Mycology laboratory of the Mohammed VI Hospital Center of Oujda. We collected demographic and mycological data for the included patients. In the laboratory, upon reception of the samples, a direct examination (DE) of the sample was obtained after clarification by KOH to better visualize the mycelial filaments or yeasts and culture on both media: Sabouraud with chloramphenicol and Sabouraud with chloramphenicol and cycloheximide is systematically carried out. Results: We collected 136 diabetic patients referred to our laboratory for suspicion of superficial mycosis. The latter was confirmed in 46 of the 136 diabetic patients (33.82%) referred to our laboratory, which corresponds to 50 lesions among the 166 sites taken, a prevalence of 30.12%. At the mycological examination, the DE allowed the confirmation of the diagnosis of mycoses in 64% (n=32) and showed most often mycelial filaments (n=21; 65.62%) especially at the level of the feet and yeasts were observed in particular at the level of the nails of the hands (n=11; 34.37%). While culture was positive in all cases without exception (100%; n=50), dermatophytes were the most frequently isolated fungi (n=30; 60%), followed by yeasts (n=20; 40%). By species, T. rubrum (n=30; 60%) was the only isolated dermatophyte species, followed by Candida albicans (n=17; 34%). Conclusion: In recent years, we have seen an increase in the prevalence of superficial mycoses in diabetic patients which is why we conducted this study. The results show on the one hand that the most isolated fungi in the superficial mycoses of these patients are dominated by dermatophytes, as T. rubrum represents the most frequently encountered species. Furthermore, the high prevalence of the latter demonstrates the significance of implementing important prevention measures.

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Prévalence et aspects cliniques des mycoses superficielles chez le diabétique tunisien en milieu hospitalier

Cited by 14 publications

References 10 publications

Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns

Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns

Bioclimatologie des infections cutanées mycosiques à Sfax (Centre-Est de la Tunisie)

Epidemiological and mycological profile of superficial mycoses in diabetic patient

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