Prévalence et caractéristiques de la dysfonction sexuelle chez des patients marocains consultant pour un premier épisode dépressif

Yazidi, F.E. El; Boualame, A.; Akammar, S.; Elfahiri, F. Zahrae; Aitbenlaassel, O.; Adali, Imane; Manoudi, F.; Asri, F.

doi:10.1016/j.encep.2019.06.003

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…The prevalence of sexual disorders in the patients with major depressive disorder has been reported differently. In some studies, this disorder was reported in nearly half of patients with major depressive disorder [ 12 , 13 ]. A meta-analysis in 2022 showed that sexual dysfunction is prevalent in females with depressive disorders who are not in the pharmacological treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial

Torkaman,

Meybodi,

Kheradmand

et al. 2024

BMC Psychiatry

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Background While some evidence suggests that l-arginine may improve sexual function and alleviate depression, it has not been investigated in women with depression to assess both its effects on the depression and sexual function concurrently. Methods Patients who had received a diagnosis of major depressive disorder, as determined by predetermined inclusion and exclusion criteria, were enrolled in this triple-blind clinical trial. Patients were divided into two groups: group A, received L-arginine 1 gram twice daily, and group B, received a placebo for four weeks. They were evaluated at baseline, after four and eight weeks with the Hamilton Depression Rating Scale (HDRS), and Rosen’s questionnaire or Female Sexual Function Index (FSFI). Results A decrease in the severity of depression was observed in all patients, which was determined due to Hamilton’s questionnaire (P-value < 0.001). During the time in group A, FSFI increased. Based on the FSFI questionnaire, they had improvement in some domains, including the lubrication index and orgasm index, which significantly changed in the eighth week compared to the baseline (P-value < 0.05). However, these two indicators did not change statistically significantly compared to the placebo group. Conclusion L-arginine supplementation can improve sexual function, particularly lubrication and orgasm, and mood in women with depression, with minimal side effects observed. Additional research is necessary to validate these results by examining the effects of higher dosages, extended durations, and larger populations of depressed patients. Trial registration Iranian Registry of Clinical Trial: IRCT20100127003210N26.

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Section: Introductionmentioning

confidence: 99%

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial

Torkaman,

Meybodi,

Kheradmand

et al. 2024

BMC Psychiatry

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“…( 3 ) reported that men with depression were 1.39 times more likely to get impotence. Sexual dysfunction was significantly correlated with the severity of depression ( 9 ). Furthermore, ED was 2.92 times more likely to lead to depression.…”

Section: Introductionmentioning

confidence: 99%

Exploring potential genes and mechanisms linking erectile dysfunction and depression

Yuan,

Chen,

Sun

et al. 2023

Front. Endocrinol.

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BackgroundThe clinical correlation between erectile dysfunction (ED) and depression has been revealed in cumulative studies. However, the evidence of shared mechanisms between them was insufficient. This study aimed to explore common transcriptomic alterations associated with ED and depression.Materials and methodsThe gene sets associated with ED and depression were collected from the Gene Expression Omnibus (GEO) database. Comparative analysis was conducted to obtain common genes. Using R software and other appropriate tools, we conducted a range of analyses, including function enrichment, interactive network creation, gene cluster analysis, and transcriptional and post-transcriptional signature profiling. Candidate hub crosslinks between ED and depression were selected after external validation and molecular experiments. Furthermore, subpopulation location and disease association of hub genes were explored.ResultsA total of 85 common genes were identified between ED and depression. These genes strongly correlate with cell adhesion, redox homeostasis, reactive oxygen species metabolic process, and neuronal cell body. An interactive network consisting of 80 proteins and 216 interactions was thereby developed. Analysis of the proteomic signature of common genes highlighted eight major shared genes: CLDN5, COL7A1, LDHA, MAP2K2, RETSAT, SEMA3A, TAGLN, and TBC1D1. These genes were involved in blood vessel morphogenesis and muscle cell activity. A subsequent transcription factor (TF)–miRNA network showed 47 TFs and 88 miRNAs relevant to shared genes. Finally, CLDN5 and TBC1D1 were well-validated and identified as the hub crosslinks between ED and depression. These genes had specific subpopulation locations in the corpus cavernosum and brain tissue, respectively.ConclusionOur study is the first to investigate common transcriptomic alterations and the shared biological roles of ED and depression. The findings of this study provide insights into the referential molecular mechanisms underlying the co-existence between depression and ED.

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“…MSDs can manifest themselves at any age and in different ways during one or more phases of normal sexual activity. Depending on the severity and duration of the disease, the problems can affect the general health of the individual concerned, the balance of the couple, and even the interactions between the patient and the rest of society (family, professional level...) (El Yazidi et al, 2019) [4]. The taboo around sexual issues in our society makes it difficult to deal effectively with the acceptance of the disease to a cure.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon

Mboumwa,

Wankeu-Nya,

Béyemé

et al. 2023

OJEpi

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Prévalence et caractéristiques de la dysfonction sexuelle chez des patients marocains consultant pour un premier épisode dépressif

Cited by 6 publications

References 29 publications

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial

Exploring potential genes and mechanisms linking erectile dysfunction and depression

Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon

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