Prevalence, extent, severity and progression of periodontal disease

Brown, L. Jackson; Löe, Harald

doi:10.1111/j.1600-0757.1993.tb00220.x

Cited by 284 publications

(226 citation statements)

References 92 publications

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“…Longitudinal epidemiological studies show that whilst 90% of the population will develop some signs of the early disease namely gingivitis, only 7-13% appear to be at high risk of developing severe destructive periodontitis (Brown and Loe, 1993). Two main forms of destructive periodontal disease are currently recognized, chronic and aggressive periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)

et al. 2010

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Periodontal disease is perhaps the most common infectious disease in humans. Gingival crevicular fluid (GCF) is a local inflammatory exudate of the periodontal tissues. Its composition greatly varies between health and periodontal disease. GCF collection is rapid and noninvasive, but previous approaches aiming to analyze its composition have mainly involved single protein biomarkers. The aim of this study was to perform analysis of the GCF exudatome from healthy and periodontally diseased sites by LC/MS E , a label-free mass spectrometry method that enables simultaneous protein identification and absolute quantification in biological fluids. In total, 154 proteins of human, bacterial, and viral origin were identified in the 40 GCF samples obtained from the 10 subjects (five healthy and five generalized aggressive periodontitis). The proportion of bacterial, viral, and yeast protein was increased in disease, compared to health. The presence of host defense-related proteins, such as Cystatin-B and defensins, was confirmed to be present only in health. Among the newly identified GCF proteins were L-plastin detected only in disease (15.6 ( 12.1 fmol) and Annexin-1 detected in 5-fold higher levels in health. Nevertheless, pro-inflammatory cytokines or periodontal pathogen proteins were rarely detected. Conclusively, the LC/MS E technology may facilitate characterization of GCF proteome in periodontal health and disease, thus conferring prognostic and diagnostic value. Larger cohort studies are required to characterize the complete GCF proteome in health and disease.

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Section: Introductionmentioning

confidence: 99%

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)

et al. 2010

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“…Chronic periodontitis (CP) is a chronic infection caused by bacteria in dental plaque of periodontal supporting tissue, leading to periodontal pocket formation, alveolar bone resorption, attachment loss, and eventually tooth loss (1). Recently, many studies have suggested that CP not only harms periodontal tissue, but also affects wholebody health (2).…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis

Wang

et al. 2016

J Oral Sci

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“…Periodontitis is initiated by specific bacterial insult, resulting in the destruction of tooth-supporting periodontal tissues, and mainly develops in adults [1,2]. The periodontal tissues are composed of four major tissues: the periodontal ligament (PDL) tissue, cementum, gingiva, and alveolar bone.…”

Section: Introductionmentioning

confidence: 99%

Biological Effects of Sprouty2 Inhibition in Periodontal Ligament Cells

Sanui¹,

Fukuda²,

Tanaka³

et al. 2016

J Cell Signal

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Prevalence, extent, severity and progression of periodontal disease

Cited by 284 publications

References 92 publications

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis

Biological Effects of Sprouty2 Inhibition in Periodontal Ligament Cells

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Prevalence, extent, severity and progression of periodontal disease

Cited by 284 publications

References 92 publications

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MSE (Gingival Exudatome)

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MSE (Gingival Exudatome)

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis

Biological Effects of Sprouty2 Inhibition in Periodontal Ligament Cells

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Product

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Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)

Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC/MS^E (Gingival Exudatome)