Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study

Rezende, GR; Lago, B.V.; Puga, MA; Bandeira, LM; Pompilio, MA; Castro, Vol; Tanaka, TS; Cesar, GA; Oliveira, Smvl De; Yassuda, Rts; Simionatto, Simone; Weis, Sms; Basílio, SF; Croda, Júlio; Motta-Castro, Ana Rita Coimbra

doi:10.1016/j.ijid.2020.04.019

Cited by 11 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, most anti-HTLV positive participants were still susceptible to HBV infection (66.7%). These results and the comparable rates found in other studies among inmates suggest that prisoners still have a greater vulnerability to HBV acquisition (Fialho et al, 2008;Rezende et al, 2020).…”

Section: Discussionsupporting

confidence: 86%

“…In the HCV prevalence study conducted in the same population, from which this study departed, injection drug use was associated with HCV exposure in male prisoners (Puga et al, 2017). In addition, the serological evidence of past HBV infection (33.3%) found in anti-HTLV positive individuals of this study was 3.4 times higher than in the prisoners enrolled in the previous study (9.8%) conducted among 3,368 inmates (Rezende et al, 2020). Moreover, most anti-HTLV positive participants were still susceptible to HBV infection (66.7%).…”

Section: Discussionmentioning

confidence: 41%

“…The samples reactive by screening and positive by WB were considered positive for HTLV-1 or 2 infections. The selected serum samples were also tested by ELISA method for anti-HIV-1/2 (Murex HIV-1.2.0, DiaSorin, Italy), anti-HCV (ELISA-Murex Diagnostics, United Kingdom), and for the presence of HBV serological markers (HBsAg, anti-HBs, and total anti-HBc) (ELISA, DiaSorin S.p.A) as described before by Sgarbi et al (2015), and Puga et al (2017) and Rezende et al (2020), respectively.…”

Section: Serological Testsmentioning

confidence: 99%

See 2 more Smart Citations

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

et al. 2022

View full text Add to dashboard Cite

Human T-lymphotropic virus (HTLV) infection is endemic in some group populations. Prisoners are at high risk of acquiring HTLV infection mainly due to the environment of closed penal institutions, socioeconomic conditions, and risk behaviors. This study aimed to investigate the prevalence, the occurrence of new cases of HTLV infection after a 1-year follow-up, and circulating subtypes of HTLV-1 among prisoners from twelve closed prisons in Mato Grosso do Sul state, Central Brazil. A total of 1,507 prisoners were randomly enrolled in the cross-sectional study. Out of the 1,507 participants, 1,000 prisoners, susceptible to HTLV infection, were included in the prospective cohort study. In the cross-sectional study, serological evidence of HTLV infection was 0.4% (CI 95%: 0.1-0.7), tested for anti-HTLV antibodies by enzyme-linked immunosorbent assay (ELISA). Three samples were positive for HTLV-1, two samples were positive for HTLV-2, and 1 sample was indeterminate by the Western blot method. The presence of HTLV proviral DNA was detected in all positive samples by amplification of the HTLV tax gene through nested-PCR. Phylogenetic analysis showed that HTLV-1 samples belonged to the Cosmopolitan subtype Transcontinental subgroup. From a cohort of 1,000 individuals, no new case of HTLV infection was detected. Although the prevalence rate of HTLV infection found in this study was similar to that observed in the Brazilian general population, the lack of access to preventive interventions and harm reduction measures all contribute to increasing the risk of HTLV transmission and acquisition among this key and vulnerable population.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 41%

Section: Serological Testsmentioning

confidence: 99%

See 1 more Smart Citation

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This high prevalence, mainly among the elderly (over 60 years old), likely reflects the geographical origin of infected individuals mainly between 1917 and 1940, when 164.000 Japanese people migrated to Brazil; 75% of these immigrants settled in São Paulo, where most of the coffee plantations were located. HBV exposure decreased among participants with higher educational levels (>9 years of education), which might be due to awareness of prevention; this finding is supported by similar observations reported by Rezende et al, 2020 [ 43 ].…”

Section: Discussionsupporting

confidence: 82%

Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

Demarchi

Bandeira

Taira

et al. 2022

Viruses

View full text Add to dashboard Cite

This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.

show abstract

“…However, the vaccine was made available free of charge to the entire population, regardless of age, only in 2015 [ 12 ]. Therefore, vaccination coverage in older adults is still incipient [ 13 , 14 ] and, associated with unsatisfactory vaccine performance in more advanced age groups, represents a challenge for public health.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Risk Factors and Vaccine Response against Hepatitis B in People Aged 50 Years or Older

et al. 2023

View full text Add to dashboard Cite

Universal immunization against hepatitis B has contributed to reducing incidence of the disease, but older individuals remain susceptible to acquiring the hepatitis B virus worldwide. Thus, this study aimed to investigate the epidemiology of HBV infection in individuals aged 50 years and over in central Brazil and to evaluate the immunogenicity of the monovalent vaccine against hepatitis B in this age group using two vaccine regimens. Method: Initially, a cross-sectional and analytical study was carried out to investigate the epidemiology of hepatitis B. Then, individuals without proof of vaccination for hepatitis B were recruited for a phase IV randomized and controlled clinical trial using two vaccine regimens: Intervention Regimen (IR) (three doses of 40 μg at months 0, 1 and 6) vs. Comparison Regimen (CR) (three doses of 20 μg at months 0, 1 and 6). Results: The overall prevalence of exposure to HBV was 16.6% (95% CI: 14.0%–9.5%). In the clinical trial, statistical differences in protective titers were observed (p = 0.007; IR 96% vs. CR 86%) and the geometric mean of anti-HBs titers was higher in individuals who received the IR (518.2 mIU/mL vs. 260.2 mIU/mL). In addition, the proportion of high responders was higher among those who received the IR (65.3%). Conclusion: reinforced doses should be used in individuals aged 50 years or older to overcome the lower efficacy of the vaccine against hepatitis B.

show abstract

Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study

Cited by 11 publications

References 35 publications

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

Prevalence, Risk Factors and Vaccine Response against Hepatitis B in People Aged 50 Years or Older

Contact Info

Product

Resources

About