Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly

Durme, Yannick M.T.A. van; Verhamme, Katia; Stijnen, Theo; Rooij, Frank J.A. van; Pottelberge, Geert R. Van; Hofman, Albert; Joos, Guy; Stricker, Bruno H. Ch.; Brusselle, Guy

doi:10.1378/chest.08-0684

Cited by 133 publications

(110 citation statements)

References 24 publications

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“…For HF, this means a 3 times higher prevalence than can be expected in the general elderly population Ն65 years old. 5,9 Also, consistent with previous studies, prevalence estimates increased with age, and men were more affected than women. Men also had more major risk factors than women.…”

Section: Discussionsupporting

confidence: 88%

“…4,5 Other diseases or precipitating factors that may simultaneously cause these symptoms should also be considered, such as anemia, atrial fibrillation, valvular disease, (persisting) asthma, thyroid disorder, and obesity. Importantly, both patients and physicians often do not seem to consider the development of another disease causing symptoms and signs similar to the patient's known condition.…”

mentioning

confidence: 99%

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Unrecognized Heart Failure and Chronic Obstructive Pulmonary Disease (COPD) in Frail Elderly Detected Through a Near-Home Targeted Screening Strategy

Mourik

Bertens

Cramer

et al. 2014

The Journal of the American Board of Family Medicine

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Background: Reduced exercise tolerance and dyspnea are common in older people, and heart failure (HF) and chronic obstructive pulmonary disease (COPD) are the main causes. We want to determine the prevalence of previously unrecognized HF, COPD, and other chronic diseases in frail older people using a nearhome targeted screening strategy.Methods: Community-dwelling frail persons aged >65 years underwent a 2-step screening strategy. First, they received a questionnaire inquiring about dyspnea and exercise tolerance. Those with exercise intolerance and/or dyspnea were invited to visit their primary care physician's office for a screening program, including medical history taking, physical examination, blood tests, electrocardiography, spirometry, and echocardiography. The final diagnosis of every patient was determined by a panel consisting of 3 physicians.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Unrecognized Heart Failure and Chronic Obstructive Pulmonary Disease (COPD) in Frail Elderly Detected Through a Near-Home Targeted Screening Strategy

Mourik

Bertens

Cramer

et al. 2014

The Journal of the American Board of Family Medicine

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“…The final aim and primary objective of this research is to establish and co-ordinate a population cohort study aimed to investigate the natural history of the most common respiratory chronic conditions, including COPD and OSA. Such a population cohort should evolve as a research framework with a hub of researchers, as has occurred with other studies such as Framingham, 17,18 Rotterdam, 19 Vlagtwedde-Vlaardingen, 20 OLIN, 21 Copenhagen 22 and others, as reviewed elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Set-up and pilot of a population cohort for the study of the natural history of COPD and OSA: the PULSAIB study

Soriano¹,

Yáñez²,

Renom

et al. 2010

Primary Care Respiratory Journal

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Aims: We describe the set-up of a population-based study focussed on respiratory conditions, and describe a pilot study -the PULmons SAns Illes Balears (PULSAIB) study -aimed at investigating the natural history of COPD, obstructive sleep apnoea (OSA), and other common chronic diseases.Methods: A cross-sectional study was designed to survey two fieldwork areas, one rural and one urban, in the Balearic Islands, Spain. Tests conducted included a questionnaire, spirometry with post-bronchodilator (PBD) test, and portable respiratory polygraphy. Results:We assessed all processes and tools to be used, and piloted them in 175 participants from Bunyola (rural) and 130 participants from the Son Pizà area (urban). Within this first cross-sectional assessment of the Balearic population aged 30 to 80 years, we report the prevalence of airflow limitation defined as a PBD FEV1/FVC ratio <0.7 and the prevalence of OSA defined as an apnoea-hypopnoea index (AHI) >10/hour. Conclusion:A cohort study in the Balearic population to investigate the natural history of COPD and OSA is feasible.

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“…Van Durme and coworkers reported a prospective population based cohort study of subjects older than 55 years living in a suburb of Rotterdam 6 . This study included 7983 participants with a median follow-up of 11 years.…”

Section: Aging and Copdmentioning

confidence: 99%

The role of telomere shortening in the development and progression of COPD

Amiri

Cooper²,

Nugent³

2013

SW Resp Crit Care Chron

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The prevalence and incidence of COPD increase with age in all populations studied. These associations suggest that normal aging could contribute to the pathogenesis of COPD. Telomeres are DNA structures at the end of chromosomes which protect DNA from degradation and unneeded recombination events. Telomere length decreases with age. At a critical length cells undergo senescence which results in changes in cell morphology, gene activity, and cytokine production. Senescent cells eventually undergo programmed cell death (apoptosis) and drop out of tissue structures. Telomeres from lung tissue and circulating leukocytes are shorter in patients with COPD. Lung biopsy specimens indicate that patients with COPD have increased numbers of apoptotic epithelial and endothelial cells. This information suggests that normal aging or accelerated aging or senescence induced by oxidant injury and/or inflammation contributes to the development of COPD. Longitudinal studies suggest that patients with shorter telomere have increased all cause and cancer mortality. Therefore, telomere attrition is associated with important consequences in these patients. In addition, animal studies suggest that patients with shorter telomeres are at increased risk of developing COPD. These observations raise the possibility that drugs designed to increase telomere length or to prevent telomere attrition might slow the progression of COPD. However, very careful studies with animal models of COPD and of malignancy are needed to determine benefits and to make certain that this genetic manipulation does not increase the risk of malignancy.

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Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly

Cited by 133 publications

References 24 publications

Unrecognized Heart Failure and Chronic Obstructive Pulmonary Disease (COPD) in Frail Elderly Detected Through a Near-Home Targeted Screening Strategy

Unrecognized Heart Failure and Chronic Obstructive Pulmonary Disease (COPD) in Frail Elderly Detected Through a Near-Home Targeted Screening Strategy

Set-up and pilot of a population cohort for the study of the natural history of COPD and OSA: the PULSAIB study

The role of telomere shortening in the development and progression of COPD

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