Prevalence, incidence and persistence of genital HPV infections in a large cohort of sexually active young women in the Netherlands

Mollers, Madelief; Hein, J. Boot; Henrike, J. Vriend; Audrey, Jessica; Ingrid, V.F. van den Broek; Jan, E.A.M. van Bergen; Antoinette, A.T.P. Brink; Wolffs, Petra; Christian, Jeanine; Chris, Jacob; Marianne, A.B. van der Sande; Hester, E. de Melker

doi:10.1016/j.vaccine.2012.10.087

Cited by 42 publications

(43 citation statements)

References 31 publications

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“…Here, we suggest that persistence of incident oral HPV16 infections increases with age among men, a finding consistent with one study conducted among women (14). Altogether, these data support the hypothesis that increased prevalence of oral HPV16 detected among men at older ages is likely due to increased duration of infections and not increased acquisition, a pattern consistent with that of cervical HPV infection persistence (21-23). Similar to factors thought to influence HPV persistence at the cervix, our observation of increased oral HPV persistence with age may be due to impairment of host immune responses (24) and elevation of inflammatory cytokines (25) that occur throughout the aging process.…”

Section: Discussionsupporting

confidence: 79%

Long-term Persistence of Oral Human Papillomavirus Type 16: The HPV Infection in Men (HIM) Study

Campbell

Kreimer

Lin

et al. 2015

Cancer Prevention Research

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Persistent infection with oral HPV16 is believed to drive the development of most oropharyngeal cancers. However, patterns of oral HPV16 persistence remain understudied, particularly among HIV-negative individuals. Oral HPV16 persistence was evaluated among 1626 participants of the HPV Infection in Men (HIM) Study. Twenty-three oral HPV16-positive men who provided an oral gargle sample on ≥2 study visits were included in the analysis. Archived oral samples from all follow-up visits were tested for HPV16 using Linear Array and INNO-LiPA detection methods. Persistence was evaluated using consecutive HPV16-positive visits held approximately 6 months apart and using the Kaplan-Meier method. Oral HPV16-positive men were aged 18–64 years (median, 36 years; IQR, 25–42) and were followed for a median of 44.4 months (IQR, 29.9–49.5). Of 13 incident infections, 4 (30.8%) persisted ≥12 months, 1 (10.0%) persisted ≥24 months, and none persisted ≥36 months (median infection duration, 7.3 months [95% CI, 6.4–NA]). Of 10 prevalent infections, 9 (90.0%) persisted ≥12 months, 8 (80.0%) persisted ≥24 months, 4 (57.1%) persisted ≥36 months, and 2 (40.0%) persisted ≥48 months (median infection duration, NA). Twelve-month persistence of incident infections increased significantly with age (P trend=0.028). Prevalent oral HPV16 infections in men persisted longer than newly acquired infections, and persistence appeared to increase with age. These findings may explain the high prevalence of oral HPV observed at older ages. Understanding oral HPV16 persistence will aid in the identification of men at high-risk of developing HPV-related oropharyngeal cancer.

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Section: Discussionsupporting

confidence: 79%

Long-term Persistence of Oral Human Papillomavirus Type 16: The HPV Infection in Men (HIM) Study

Campbell

Kreimer

Lin

et al. 2015

Cancer Prevention Research

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“…Recent epidemiological studies show high HPV51 frequency in several geographical areas of Europe, and among them is the eastern Mediterranean. In a German population study of young women, HPV51 was ranked second after HPV16 (24), and similar data were observed in the Netherlands (25). Among Turkish women, HPV51 is ranked third (26).…”

Section: Discussionsupporting

confidence: 65%

Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia

Kovačević¹,

Nikolić²,

Jovanovic-Galovic³

et al. 2016

Turk J Med Sci

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Background/aim: The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results. Materials and methods:In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used.Results: Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results of the LSD test show a wide spectrum of high risk HPV among women with normal cytology and women with a low grade cervical lesion rate (atypical squamous cell of undetermined significance (ASCUS) and low grade squamous intraepithelial lesions (LSIL). The most prevalent HPV types found were 16, 31, 51, 18, and 52. In the HSIL group the most prevalent HPV types were 16 and 45. Conclusion:The reported results provide new data on the circulation of oncogenic HPV genotypes and frequency of multiple infections among women in Vojvodina and suggest that a prophylactic vaccine against HPV 16 and 18 has the potential to prevent approximately half of the high-grade lesions.

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“…Potential risk factors for HPV persistence that were determined previously in various studies are age, age at first intercourse, number of sex partners (lifetime and recent), smoking, contraception methods, chlamydia and herpes simplex virus infection, chronic inflammation, immunosuppressive conditions, and menopause (34)(35)(36)(37)(38)(39)(40)(41)(42)(43). Results from these studies, however, were inconsistent partly because different populations had been studied.…”

Section: Discussionmentioning

confidence: 99%

Elevated Expression of Human Papillomavirus-16/18 E6 Oncoprotein Associates with Persistence of Viral Infection: A 3-Year Prospective Study in China

Kang

Zhao

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: An association between high-risk human papillomavirus (HR-HPV) oncoprotein expression and viral persistence has been suggested by the outcome of etiology studies, but there are no epidemiologic studies evaluating that link.Methods: We performed a 3-year prospective study in which 2,498 Chinese women ages 25 to 65 years were screened by six screening tests, including the OncoE6 Cervical Test (Arbor Vita Corporation) in 2011 (baseline). Six-hundred and ninety women who were positive for any of the tests and a random sample of 164 women with all negative results received colposcopy, and cervical specimens for the cobas 4800 HPV test ("cobas," Roche Molecular Systems) were collected before colposcopy; of this group, 737 cervical specimens were collected to perform cobas and OncoE6 Cervical Test in 2014 (follow-up). Twenty-four cases of HPV16/18 E6 positives and 204 selected controls at baseline, 13 cases of

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Prevalence, incidence and persistence of genital HPV infections in a large cohort of sexually active young women in the Netherlands

Cited by 42 publications

References 31 publications

Long-term Persistence of Oral Human Papillomavirus Type 16: The HPV Infection in Men (HIM) Study

Long-term Persistence of Oral Human Papillomavirus Type 16: The HPV Infection in Men (HIM) Study

Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia

Elevated Expression of Human Papillomavirus-16/18 E6 Oncoprotein Associates with Persistence of Viral Infection: A 3-Year Prospective Study in China

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