Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents

Abstract

We aimed at investigating the microbiological and epidemiological features of clade C fluoroquinolone-resistant ST131 E. coli isolates colonizing highly dependent residents in long-term care facilities (LTCFs) during 40 weeks and the risk factors of acquisition. Isolates from C1 and C2 subclades were characterized in this environment.

Regional spread of an atypical ESBL-producing Escherichia coli ST131H89 clone among different human and environmental reservoirs in Western Switzerland

“…The second study was a cross-sectional analysis among 606 residents from 16 LTCFs in Western and Eastern Switzerland (cantons Vaud and St. Gallen) in 2019 ( 5 ). As part of an international research consortium (Understanding and modelling reservoirs, vehicles and transmission of ESBL-producing Enterobacteriaceae in the community and long-term care facilities MODERN) ( 6 ), we obtained microbiological data from a 2-year prospective international cohort of discharged patients with intestinal ESBL - EC carriage and their household contacts ( 2 ), LTCFs residents [only Spanish data published ( 7 )], and environmental E. coli strains from Geneva (Western Switzerland) but also from non-Swiss sites including Sevilla (Spain), Tübingen (Germany), Utrecht (Netherlands), and Besançon (France), collected between 2017 and 2019 ( 3 ). Further information about study design, microbiological data, and processed samples is included in Table S2.…”