“…These include chromosomal abnormalities (chromosomes 3 and 10), alcohol consumption, toxoplasmosis, rubella, cytomegalovirus and herpes simplex (TORCH) infections, maternal diabetes, maternal exposure to teratogenic drugs (lithium, aspirin, retinoic acid, amidopyrine, corticosteroids, anti-convulsant) and ionic radiation [11,14,15]. In our case, none of these factors were identified, although we cannot completely rule them out since the use of over-the-counter drugs and street medications are common in our setting [16,17]. Antenatal ultrasonography is very effective in the diagnosis of holoprosencephaly between 21 weeks and 35 weeks of gestation and a confirmation is made by a coronal view of the brain in the presence of the absence of cavum septum pellucidum with squaring and fusion of fontal horns.…”