Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population

Simmons, Jill H.; Sheedy, Craig A.; Lee, Haerin; Koh, Shannon J.; Alvarez, JoAnn; Koyama, Tatsuki; Friedman, Debra L.

doi:10.1002/pbc.24684

Cited by 14 publications

(19 citation statements)

References 31 publications

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“…The observed correlation was almost entirely driven by time spent in the sun rather than the amount of exposed skin, suggesting that the categories for time exposed to sunlight proposed by them (<5 min, 5–30 min and >30 min) are easily recalled and likely to be of biological significance. Positive (but moderate) correlations of sun exposure score and 25(OH)D concentrations were also seen among North‐American youths (1–21 years old) . Wakayo et al .…”

Section: Discussioncontrasting

confidence: 92%

Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents

Giudici

Fisberg

Marchioni

et al. 2016

J Human Nutrition Diet

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Section: Discussioncontrasting

confidence: 92%

Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents

Giudici

Fisberg

Marchioni

et al. 2016

J Human Nutrition Diet

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“…In our study, low serum vitamin D levels were not associated with development of any or severe GVHD in the unadjusted or adjusted models; however, our analysis was limited due to the lack of standardized collection times at baseline and during the posttransplantation period and should be viewed purely as exploratory data. With evidence that many pediatric patients have low levels of 25(OH)D both at the time of transplantation and during the posttransplantation period, a larger prospective study is needed to determine whether a similar association with aGVHD is present in children …”

Section: Discussionmentioning

confidence: 99%

Nutritional risk factors predict severe acute graft‐versus‐host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation

Kerby

Getz

et al. 2017

Pediatric Blood & Cancer

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“…The control population data was collected from a de-identified database of 100 healthy pediatric patients who live in similar middle-Tennessee geography, as previously reported [19]. This population included individuals between the ages of 1 -21 years who live in similar middle-Tennessee geography and who were having bloodwork obtained at an outpatient clinic at Vanderbilt Children's Hospital.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Abnormalities: More Common in US Children with T1D than in Healthy Children

Sheedy¹,

Xu²,

Saville³

et al. 2014

JDM

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Background: Pediatric patients with type 1 diabetes (T1D) have increased risk for low bone mineral density, which may be due in part to low 25-hydroxyvitamin D levels. Vitamin D levels are influenced by sunlight exposure and thus display geographical variation. We hypothesize that the prevalence of 25-hydroxyvitamin D deficiency (<20 ng/mL) and insufficiency (20 -29 ng/mL) in children with T1D living in the United States is higher than in healthy children and that diabetes duration, HbA1c, and insulin dose/kg are inversely associated with 25-hydroxyvitamin D levels. Methods: Medical records of patients with T1D being followed in Tennessee were reviewed for demographics, medical information, and 25-hydroxyvitamin D levels during the previous 2 years. Control subjects were obtained from a de-identified database of healthy pediatric subjects living in a similar geographical area. Chi squared tests and multivariable linear regression were performed. Results: Children and adolescents with T1D (n = 276; median age 14 years) have a significantly higher percentage of vitamin D deficiency and insufficiency compared with healthy pediatric controls (n = 100; median age 11.2 years) (68% versus 44%; p < 0.001). The median 25-hydroxyvitamin D level is 24 ng/mL versus 31 ng/mL, respectively. After adjusting for age, race, gender, UV light exposure, BMI, and multivitamin supplementation, children and adolescents with T1D have a serum 25-hydroxyvitamin D level 6.7 ng/mL lower than the control population [CI (4.11, 9.21), p < 0.0001]. Within the T1D population, there is no clear association between diabetes duration, HbA1c, or insulin dose/kg and 25-hydroxyvitamin D levels. Conclusions: There is an increased prevalence of 25-hydroxyvitamin D deficiency and insufficiency in US. children with T1D compared with geographically similar children without diabetes. Further research is needed to determine whether decreased serum 25-hydroxyvitamin D can be alleviated via dietary or behavioral modifications in this population. C. Sheedy et al.325

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Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population

Cited by 14 publications

References 31 publications

Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents

Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents

Nutritional risk factors predict severe acute graft‐versus‐host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation

Vitamin D Abnormalities: More Common in US Children with T1D than in Healthy Children

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