Prevalence of abnormal serum alanine aminotransferase levels in obese patients and patients with type 2 diabetes

Erbey, John R.; Silberman, C; Lydick, Eva

doi:10.1016/s0002-9343(00)00602-1

Cited by 76 publications

(45 citation statements)

References 7 publications

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“…Some prospective studies have indicated that elevated GGT, even in the normal range, is associated with type 2 diabetes. 19,20 In addition, abnormal liver function test results were also found in other studies among populations with diabetes. 21,22 We suggest that liver function should be assessed regularly for IFG populations to avoid deterioration.…”

supporting

confidence: 62%

Diabetes and Its Chronic Complications in the She Ethnic Minority Group of China

Lin

Chen

et al. 2012

Diabetes Technology & Therapeutics

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Objective: According to recent reports, the development of type 2 diabetes in China has soared at an alarming rate. However, most of the investigations were based on Han people, who account for the majority of people in China. Little is known about the prevalence of diabetes its chronic complications in the She people, who have their own traditional lifestyle and hereditable background, different from other Asian population. The present study investigated the prevalence of type 2 diabetes and associated risk factors in the adult population of She nationals. Subjects and Methods: A total of 5,385 participants entered into the analysis eventually, including 2,308 men and 3,077 women. An oral glucose tolerance test was performed in subjects without diagnosed diabetes. Liver function, cardiovascular risk (brachial-ankle pulse wave velocity, estimated glomerular filtration rate, and abnormal Minnesota codes findings), uric acid, and neuropathy were tested to assess the profiles of associated risks. Results: In general, the self-reported diabetes rate was 9.5%. After age and sex standardization, the prevalence of diabetes was 6.1% (6.7% for men and 5.7% for women) in She Chinese people. In logistic regression models, age, family history of diabetes, alcohol use, total cholesterol, and triglycerides were all significantly associated with the risk of diabetes in this cross-sectional study (all P < 0.05). In all, 47.4% had cardiovascular risks, 19.4% had liver dysfunction, and 6.2% had hyperuricemia. For women, compared with the first quartile, log-transformed homeostasis model assessment for insulin resistance of the fourth quartile was significantly higher (P < 0.05), and log-transformed homeostasis model assessment for b cells was also higher in the second, third, and fourth quartiles (all P < 0.05). The prevalences of polyneuropathy in impaired fasting glucose (IFG), impaired glucose tolerance (IGT), IFG/IGT, and diabetes mellitus (DM) were 16.1%, 13.1%, 18.6%, and 28.4% separately, which was higher than that in normal glucose tolerance. The prevalences of polyneuropathy in IFG/IGT and DM were higher than that in IGT. Conclusions: The present study revealed that a total of 6.1% She people suffered from type 2 diabetes, which was lower than the average level of China, but the standardized prevalence of prediabetes was higher, 20.6%. Early peripheral neuropathy screening should be performed in the prediabetes population. The Toronto Clinical Neuropathy Scoring System is convenient to assess diabetic polyneuropathy in clinical practice and should be tested regularly for people in prediabetes. Liver dysfunction, headache, and insomnia, appearing before type 2 diabetes, should be assessed regularly to avoid deterioration.

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supporting

confidence: 62%

Diabetes and Its Chronic Complications in the She Ethnic Minority Group of China

Lin

Chen

et al. 2012

Diabetes Technology & Therapeutics

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“…[3,4,[9][10][11][12]22] and some cases of 'cryptogenic cirrrhosis' may be attributable to NASH, in which the histological features of steatohepatitis have resolved [8,9,[14][15][16][17][18]27]. Rare cases of sub-acute hepatic failure have also been attributed to possible NASH [28].…”

Section: Discussionmentioning

confidence: 99%

Clinico-Pathological Profile of NAFLD in Type 2 Diabetes Mellitus

KP¹

2017

JMSCR

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“…In their study, Erbey et al 6 reported that there were elevated levels of ALT in diabetic patients 7.8% compared to 3.8% in control subjects. Salmela et al 7 reported the findings of their study as increased levels of ALT among diabetics to be associated with increased BMI and poor glycemic control.…”

Section: Introductionmentioning

confidence: 90%

The Influence of Metformin Treatment on Liver Function of Diabetic Patients Attending Jordanian Royal Medical City

Sweis¹,

Al-Maani²,

braikat³

et al. 2017

IRJPS

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ABSTRACT:Introduction: Liver is a vital organ and mediates many cellular processes. Liver may be injured in diabetes. Metformin treatment shows a high potential to lower the risk of liver injury or to ameliorate its damage. Study objective:To explore the potential of metformin treatment in reducing the level of liver injury. Methods and subjects:The present study employed the retrospective study design to review the files of diabetic patients. Study variables includedgender, age, duration of diabetes, metformin treatment, and liver function tests. Datawere analyzed using SPSS version 21. The relationship between variables was examined using Chi-square test, and T test. Significance was considered if p< 0.05. Study results:The study included 62 diabetic patients. The mean age of study participants was 62.95± 11.98 years, a total of 33 (53.22%) of study participants were males, duration of diabetes was 7.51±5.86 years, metformin was used as a diabetic therapeutic option by 41 (66.13%), the mean dose of metformin was 1617.32±694.49 mg, the mean level of AST was 16.01±7.79 (U/L), the mean level of ALT was 18.500±8.89 (U/L), and the mean level of bilirubin was 0.38±0.18 (mg/dl). A significant relationship was found between metformin dose and each of liver enzymes (p=0.000). When the mean levels of liver enzymes were compared between metformin group and without metformin group, no significant differences were observed. Conclusion:Liver injury in diabetes is a long term process and the use of metformin can offer protection against liver injury through keeping liver enzymes within normal limits.

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Prevalence of abnormal serum alanine aminotransferase levels in obese patients and patients with type 2 diabetes

Cited by 76 publications

References 7 publications

Diabetes and Its Chronic Complications in the She Ethnic Minority Group of China

Diabetes and Its Chronic Complications in the She Ethnic Minority Group of China

Clinico-Pathological Profile of NAFLD in Type 2 Diabetes Mellitus

The Influence of Metformin Treatment on Liver Function of Diabetic Patients Attending Jordanian Royal Medical City

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