Prevalence of Acinetobacter Baumannii Isolated From Clinical Specimens in Adam Malik Hospital

Abstract

AbstrakAcinetobacter baumannii merupakan spesies Acinetobacter spp. tersering diisolasi dari manusia, dan lebih sering dijumpai pada infeksi nosokomial dibandingkan dengan infeksi di komunitas. Eksistensi bakteri ini di lingkungan terkait dengan keragaman reservoir, kemampuan memperoleh gen pembawa sifat resisten antimikroba, dan sifat resisten terhadap pengeringan. Infeksi disebabkan strain A.baumannii yang resisten terhadap banyak antibiotik tidak mudah dikendalikan dan menjadi permasalahan di berbagai negara. Penelitian ini bertujuan untuk mengetahui prevalensi A.baumannii dari spesimen klinis di instalasi mikrobiologi klinik RSUP Haji Adam Malik serta pola kepekaannya terhadap berbagai antibiotik. Identifikasi dan uji kepekaan menggunakan mesin otomatis Vitek 2 dengan Advanced Expert System (AES). Penelitian ini menemukan 644/3693 (17,44%) isolat A.baumannii dari berbagai spesimen klinis. A.baumannii paling banyak diisolasi dari spesimen dahak. Penelitian ini menemukan 147/644 (23%) bahwa isolat carbapenem-resistent A.baumannii (imipenem dan meropenem). Sebagian besar isolat sensitif terhadap colistin, amikacin dan tigecycline. Prevalensi A.baumanni yang ditemukan pada penelitian ini adalah rendah namun resistensinya tinggi terhadap antibiotik terutama golongan penicillin, cephalosporin dan fluoroquinolon.Kata kunci: A. baumannii, spesimen klinis, pola kepekaan, carbapenem-resistent A.baumannii Abstract Acinetobacter baumannii is the most frequent species of Acinetobacter spp. isolated from humans and more common in nosocomial infection than it is in community acquired infection. A.baumannii existence in environment is associated with the diversity of its reservoirs, its capacity to accumulate genes of antimicrobial resistence, and its resistence to desiccation. Infection of Multidrug resistent (MDR) strain of A.baumannii is not easy to manage and it has become a problem in many countries. The aim of this retrospective study was to investigate the prevalence of A.baumannii from routine clinical specimens sent to clinical microbiology laboratory RSUP HAM Medan and its susceptibility pattern to various antibiotics. Identification and susceptibility testing of A. baumannii was performed by Vitek 2 with Advanced Expert System (AES

Multi Drug Resistance and Multi Antibiotics Resistance Index of Acinetobacter baumannii Isolated from Hospitals in Port Harcourt Metropolis

“…Acinetobacter baumanii has remained an issue of great concern. This is attributed to different factors including the enormous ability of Acinetobacter baumanii to spread from along with colonization of human and environmental reservoirs [24] Detection of this organism in the samples used here is in conformity with Mayasari & Siregar [8]. Detection in these samples indicates colonization of some body systems and tracts such as the skin and urinary tracts.…”

“…"Acinetobacter baumannii has become increasingly responsible for causing hospital acquired infections (HAI), particularly in intensive care units (ICUs)" [7]. "It has been isolated from blood, sputum, skin, pleural fluid, and urine, usually in device associated infections" [8]. "The species are excellent biofilm producing bacteria, which facilitate their survival in hospital environments and are frequently found on the skin and in the respiratory and urinary tracts of hospitalized patients" [9].…”

Multidrug resistance pattern of Acinetobacter species isolated from clinical specimens referred to the Ethiopian Public Health Institute: 2014 to 2018 trend anaylsis

“…Acinetobacter baumannii has become increasingly responsible for causing hospital acquired infections (HAI), particularly in intensive care units (ICUs) [ 4 ]. It has been isolated from blood, sputum, skin, pleural fluid, and urine, usually in device associated infections [ 5 ]. The species are excellent biofilm producing bacteria, which facilitate their survival in hospital environments and are frequently found on the skin and in the respiratory and urinary tracts of hospitalized patients [ 6 ].…”

THE AUTOMATIC MICRODILUTION-BROTH IN SENSITIVITY TESTING OF ACINETOBACTER BAUMANNII ISOLATES (Microdilution-Broth Otomatis Dalam Uji Kepekaan Isolat Acinetobacter Baumannii)

“…No wonder the strain of Acinetobacter resistant to carbapenem is rapidly found around the world, creating a challenge in treatment. 9 Research conducted by Mayasari 10 and Siregar 10 as well as by Kardana 11 showed that the resistance level of A.baumannii to meropenem was quite high.…”