Prevalence of ADRs and Associated Factors of Antiretroviral Treatment on HIV Positive Adults at Jush

Tatiparthi, Ramanjireddy; Mamo, Yitagesu

doi:10.5530/ijopp.7.4.3

Cited by 7 publications

(11 citation statements)

References 28 publications

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“…This is consistent with research conducted in Ethiopia and Ghana [21,4]. In contrast to these findings, a study in HIV infected patients at an ART Centre of tertiary care hospital in India showed a higher prevalence in males than in females [22].…”

Section: Discussioncontrasting

confidence: 54%

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Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Takaki¹,

Quirelli²,

Cuman³

2017

Trop. J. Pharm Res

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79 (35.9 %). Gastrointestinal disorders (25.9 %), hypertension (25.4 %), and neuropsychiatric symptoms (18.2 %) were the most common clinical ADRs. The most common laboratory-based ADRs were anemia (48.8 %), hypertriglyceridemia (47.3 %), hypercholesterolemia (36.1 %) and hyperglycemia (22.6 %). Conclusion:The results demonstrate a high incidence of ADRs in HIV-patients treated with HAART, which should be monitored closely during follow-up therapy.

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Section: Discussioncontrasting

confidence: 54%

“…Further, it has been reported that up to 80 % of HIV -infected patients experience ADRs during their therapy, presumably as a result of immune dysregulation, altered drug metabolism and/or drug interactions [21].…”

Section: Discussionmentioning

confidence: 99%

Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Takaki¹,

Quirelli²,

Cuman³

2017

Trop. J. Pharm Res

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“…A study conducted in Jimma University specialized hospital, Ethiopia, on HIV patients under highly active antiretroviral therapy (HAART) showed that 70.8% of them had developed ADRs [21].…”

Section: Introductionmentioning

confidence: 99%

“…However, in Ethiopia despite the potential risks of adverse drug reactions, to date there are about 600 ADR cases reported per year to the national pharmacovigilance center. The available reports at the national medicine regulatory authority are very low as compared to the World Health Organization's recommended adverse drug reaction reporting rate, which is 200 reports per million population per year [20,21,[24][25][26][27]. Adverse drug reaction reporting experiences among medical doctors in Addis Ababa are not well known and the reasons are not properly explored.…”

Section: Introductionmentioning

confidence: 99%

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Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia

2020

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Introduction Adverse drug reactions (ADRs) are global public health problems. In its severe form it may cause hospital admission, morbidity and mortality. Early reporting of suspected ADRs to regulatory authorities is known to be appropriate measure toinsure health and safety of public form such adverse drug reaction of drugs. In Addis Ababa, there is limited information on ADR reporting practices among medical doctors. Hence, this study aimed to assess ADR reporting practices and associated factors among doctors in government hospitals in Addis Ababa. Methods An institution based cross-sectional mixed-methods study design was used. Data werecollected from 407 doctors using self-administered questionnaire and five key informants using semi-structured questionnaire from October 01 to December 31, 2017. Binary logistic regression and thematic analysis methods for quantitative and qualitative data analysis were used respectively. Results Only 94(27.4%) of doctors had ever reported ADRs to national pharmacovigilance center. The study showed that sex (

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Incidence and Predictors of Severe Adverse Drug Reactions among Patients on Antiretroviral Drugs in Harari Regional State, Eastern Ethiopia

Anbessa,

Hawulte,

Dingeta

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. The introduction of combination antiretroviral therapy improves the quality and longevity of people living with HIV/AIDS. However, adverse drug reactions associated with antiretroviral therapy compromise the resulting benefits and have been reported differently worldwide, including Ethiopia. Severe adverse drug reactions are one of the major public health concerns for the reason that they can potentially impede the benefit of antiretroviral therapy and put the patient’s survival at risk. Despite many successes achieved with the introduction of the combined antiretroviral therapy, the majority of the patients on antiretroviral therapy experience adverse drug reactions associated with the drugs. Consequently, little is known about the problem in the current study area. This is, therefore, to study incidence and predictors of severe adverse drug reactions among patients on antiretroviral drugs in the Harari region, Eastern Ethiopia. The aim of this study was to assess the incidence and predictors of severe adverse drug reactions among patients on antiretroviral therapy from February 25, 2022, to March 25, 2022, in the Harari region, Eastern Ethiopia. Methods. A hospital-based retrospective cohort study was conducted among 449 randomly selected medical records of people living with HIV on first-line antiretroviral therapy. Collected data were entered into EpiData version 3.1 and exported to STATA version 15 for analysis. Kaplan–Meier survival curve with log-rank test was used to compare survival curves for categorical independent variables. A p value ≤0.05 was declared as significant, and an adjusted hazard ratio was used to report the effect size using the multivariate Cox proportional hazard model. Result. The overall incidence density of the severe adverse reactions was 7.22 per 1000 months (95% CI: 5.5, 9.6). After adjusting for all potential confounders using multivariable Cox proportional hazard ratio, advanced clinical diseases (AHR = 3.44; 95% CI: 1.54, 7.65), HIV/tuberculosis confections (AHR = 2.38; 95% CI: 1.23, 4.62), and being female (AHR = 3.12; 95% CI: 1.57, 6.18) were significantly associated with the experience of severe adverse drug reactions. Conclusion. In this study, the incidence of severe adverse reactions was consistent with the previous studies, and advanced World Health Organization (WHO) clinical stage, HIV/TB confection, and being female were the independent predictors of the severe adverse drug reactions.

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Prevalence of ADRs and Associated Factors of Antiretroviral Treatment on HIV Positive Adults at Jush

Cited by 7 publications

References 28 publications

Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia

Incidence and Predictors of Severe Adverse Drug Reactions among Patients on Antiretroviral Drugs in Harari Regional State, Eastern Ethiopia

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