Prevalence of age-associated memory impairment and dementia in a rural community.

Coria, F; Caso, José Ángel Gómez de; Mínguez, Luis A.; Rodríguez‐Artalejo, Fernando; Clavería, L. E.

doi:10.1136/jnnp.56.9.973

Cited by 86 publications

(52 citation statements)

References 20 publications

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“…The prevalence rate of AAMI in our study was much lower compared with an earlier study on 65-to 69-yearold subjects [25]. However, in a door-to-door survey on 65-to 74-year-old individuals, a rate of 3% has been estimated [26], which is closer to our estimate. For all the diagnoses studied here, we are not able to comment on the effect of age on increasing prevalence in our study due to the narrow age range of our subjects.…”

Section: Discussioncontrasting

confidence: 52%

Prevalence of Mild Cognitive Impairment in 60- to 64-Year-Old Community-Dwelling Individuals: The Personality and Total Health through Life 60+ Study

Kumar

Dear

Christensen

et al. 2005

Dement Geriatr Cogn Disord

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This epidemiological study aimed at determining the prevalence of mild cognitive impairment (MCI) in 60- to 64-year-old individuals using different diagnostic criteria. Community dwelling individuals (n = 2,551) in the age range of 60–64 years were recruited randomly through the electoral roll. They were screened using the MMSE and a short cognitive battery, and those who screened positive underwent detailed medical and cognitive assessments. Extant MCI-related diagnoses were established by consensus. Predictive regression models on the sub-sample were used to determine population prevalence for the diagnoses. Of the 224 subjects who screened positive for MCI, 112 underwent a detailed assessment and 74% met the criteria for at least one recognised diagnosis of mild cognitive deficit (MCI and related diagnoses). By predictive regression modelling, the prevalence of any MCI diagnosis was 13.7% (95% CI 9.1–30.2) in the population of 60- to 64-year-olds. The estimated prevalence rates for specific diagnoses were: MCI 3.7%, ageing-associated cognitive decline 3.1%, Clinical Dementia Rating score (0.5) 2.8%, age-associated memory impairment 1%, other cognitive disorders 0.9%, and mild neurocognitive disorder 0.6%. Agreement on ‘caseness’ between various proposed diagnoses was at best fair and generally poor. Memory and other cognitive problems not meeting the threshold for dementia are relatively common in 60- to 64-year-old individuals living in the community. The prevalence rate varies up to six-fold according to the diagnostic criteria applied, with limited overlap between diagnoses. There is an urgent need for standardization of the criteria.

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Section: Discussioncontrasting

confidence: 52%

Prevalence of Mild Cognitive Impairment in 60- to 64-Year-Old Community-Dwelling Individuals: The Personality and Total Health through Life 60+ Study

Kumar

Dear

Christensen

et al. 2005

Dement Geriatr Cogn Disord

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“…Therefore, how these criteria are operationalised is critical for identifying a ''pathological'' MCI syndrome, and this may have explained the wide range of estimates of the prevalence of MCI. Among the studies using the AAMI criteria, the MCI prevalence ranged from 7.1% (in subjects aged over 65), 17 to 53.8%. 18 In other study, the prevalence for AAMI was 18.5%, using cut off points adjusted for age, 19 but 40% met the criteria if no age adjustments were made.…”

mentioning

confidence: 99%

Neuropsychological characteristics of mild cognitive impairment subgroups

López¹

2006

Journal of Neurology, Neurosurgery & Psychiatry

158

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Objective: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study. Methods: MCI was classified as MCI-amnestic type (MCI-AT): patients with documented memory deficits but otherwise normal cognitive function; and MCI-multiple cognitive deficits type (MCI-MCDT): impairment of at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who had not crossed the dementia threshold. The MCI subjects did not have systemic, neurological, or psychiatric disorders likely to affect cognition. Results: MCI-AT (n = 10) had worse verbal and non-verbal memory performance than MCI-MCDT (n = 28) or normal controls (n = 374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function than MCI-AT or normal controls. MCI-MCDT subjects had memory deficits, though they were less pronounced than in MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. MCI-MCDT with memory disorders had more language deficits than MCI-MCDT without memory disorders. By contrast, MCI-MCDT without memory deficits had more fine motor control deficits than MCI-MCDT with memory deficits. Conclusions: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16% of all MCI cases and 21.5% of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.

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“…This aspect is particularly suggestive in Spain [10,11] . Although some variability between countries can be explained [12][13][14] , methodological aspects have the greatest impact, particularly the screening instruments [15] , the institutional characteristics of the population studied, or even the diagnostic coding system used. In addition to increased age, a number of other risk factors for VD have been reported.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Resource Utilization and Costs of Vascular Dementia Compared to Alzheimer’s Dementia in a Population Setting

Sicras

Rejas

Arco

et al. 2005

Dement Geriatr Cogn Disord

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Objectives: To determine the prevalence of dementia and to measure the monetary impact and health resources utilization of vascular dementia (VD) compared to Alzheimer’s dementia (AD) in persons aged over 64 years in a population setting. Methods: Retrospective, cross-sectional study. In the initial phase, information was obtained on specific clinical characteristics from the subjects with an active diagnosis of dementia. The second phase consisted of a clinical evaluation and validation of the cases. Mini-Mental State Examination was used to assess cognitive impairment. Dementia and its subtypes were determined using established diagnostic criteria. Information was obtained on the use of health care resources (direct costs) and the number of hours devoted by the primary caregiver (indirect costs) for patients with a documented diagnosis of AD or VD within the last 6 months prior to the interview. A multiple logistic regression analysis was performed to correct the model. Results: A total of 6,004 subjects were analyzed, 258 with diagnosis of dementia (overall prevalence: 4.3%). An evaluation was made of 224 patients, and gross prevalence of AD and VD was 2.4 and 1.0%, respectively. Cost per patient per semester was EUR 8,086 for AD and EUR 11,039 for VD (p = 0.016). 85.5% of the cost was attributable to primary caregiver time in AD and 84.4% in VD. Conclusions: The prevalence of AD and VD increases with age. No sociodemographic differences were seen between AD and VD. Costs associated with health care resource and primary caregiver utilization were high, being higher in VD than in AD.

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Prevalence of age-associated memory impairment and dementia in a rural community.

Cited by 86 publications

References 20 publications

Prevalence of Mild Cognitive Impairment in 60- to 64-Year-Old Community-Dwelling Individuals: The Personality and Total Health through Life 60+ Study

Prevalence of Mild Cognitive Impairment in 60- to 64-Year-Old Community-Dwelling Individuals: The Personality and Total Health through Life 60+ Study

Neuropsychological characteristics of mild cognitive impairment subgroups

Prevalence, Resource Utilization and Costs of Vascular Dementia Compared to Alzheimer’s Dementia in a Population Setting

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