Prevalence of age-related macular degeneration among optometric telemedicine users in Spain: a retrospective nationwide population-based study

Zapata, Miguel Á.; Bures, Anniken; Gallego-Pinazo, Roberto; Gutiérrez-Sánchez, Estanislao; Oleñik, Andrea; Pastor, Salvador; Ruiz‐Medrano, Jorge; Salinas, Cecilia; Otero‐Romero, Susana; Abraldes, Maximino

doi:10.1007/s00417-021-05093-4

Cited by 11 publications

(12 citation statements)

References 30 publications

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“…In conclusion, our current study suggests that the consistent long-term use of an at-home monitoring system may provide a significant benefit to patients as a means of increasing early detection of nAMD with good vision, a known strong predictor for long-term preservation of vision [13,14]. AMD has been long established as a common condition in the elderly population [37]. In today's COVID-19 pandemic environment and beyond, the ability to provide quality care to patients at high risk of converting to nAMD while limiting their potential exposure to COVID-19 bestows additional value.…”

Section: Discussionmentioning

confidence: 99%

Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration

Heier

Holekamp

et al. 2021

JCM

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The real-world performance of a home telemonitoring strategy (ForeseeHome AMD Monitoring System®, Notal Vision, Inc.,Manassas VA, USA) was evaluated and compared to the device arm of the AREDS2-HOME study among patients with intermediate AMD (iAMD) who converted to neovascular AMD (nAMD). All patients with confirmed conversion to nAMD who used the home monitoring system from 10/2009 through 9/2018 were identified by Notal Vision Diagnostic Clinic’s medical records. Selected outcome variables were evaluated, including visual acuity (VA) at baseline and at conversion, and change in visual acuity (VA) from baseline to time of conversion. In total, 8991 patients performed 3,200,999 tests at a frequency of 5.6 ± 3.2 times/week. The 306 eyes that converted from iAMD to nAMD over the study period (a 2.7% annual rate) were included in the analyses. There was a median (interquartile range) change of −3.0 (0.0–(−10.0)) letters among converted eyes, 81% [95% confidence interval (72–88%)] maintained a VA ≥ 20/40 at the time of conversion, while 69% of the conversion detections were triggered by system alerts. The real-world performance of an at-home testing strategy was similar to that reported for the device arm of the AREDS2-HOME study. The home telemonitoring system can markedly increase early detection of conversion to nAMD.

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Section: Discussionmentioning

confidence: 99%

Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration

Heier

Holekamp

et al. 2021

JCM

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“…Age-related macular degeneration (AMD) is the main reason for blindness in Europe, and approximately every tenth person over 55 years is affected by the disease (Zapata et al, 2021). The prevalence of AMD in 2020 was evaluated at 196 million cases, and this has been estimated to increase to 288 million by 2040 (Wong et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Regulation of oxidative stress and inflammatory responses in human retinal pigment epithelial cells

Harju

2022

Acta Ophthalmologica

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Age‐related macular degeneration (AMD) is an eye disease, which causes impaired vision that can lead to blindness. The incidence of AMD increases with age. Retinal pigment epithelial (RPE) cells maintain retinal homeostasis and support the functionality of photoreceptors. In the pathogenesis of AMD, the degeneration of the RPE cells precedes photoreceptor cell death. RPE cells are susceptible to oxidative stress, and chronic inflammation involving nucleotide‐binding domain, leucine‐rich repeat and pyrin domain 3 (NLRP3) inflammasome activation and impaired autophagy are challenges faced by aged RPE cells in AMD. There are two types of AMD, dry (85–90%) and wet (10–15%) disease forms. Choroidal neovascularization is typical for wet AMD, and anti‐vascular endothelial growth factor (anti‐VEGF) injections are used to prevent the progression of the disease but there is no curative treatment. There is no cure for the dry disease form, but antioxidants have been proposed as a potential treatment option.Ageing is the most important risk factor of AMD, and tobacco smoke is the most important environmental risk factor that can be controlled. Hydroquinone is a cytotoxic, immunotoxic, carcinogenic and pro‐oxidative component of tobacco smoke. The aim of this PhD thesis was to study hydroquinone‐induced oxidative stress and NLRP3 inflammasome activation in human RPE cells (ARPE‐19 cells). An age‐related eye disease study (AREDS) formulation (incl. omega‐3 fatty acids, vitamin C and E, copper, zinc, lutein and zeaxanthin), which is clinically investigated p.o. dosing combination of dietary supplements for AMD patients, has been evaluated as a possible treatment and restraining option for AMD. Resvega (4.1.1, Table 2) is a similar kind of product to AREDS with added resveratrol, and many of the components incorporated within Resvega can be considered as belonging to the normal antioxidative defence system of the retina. Another aim was to evaluate the effects of Resvega on hydroquinone‐induced oxidative stress or NLRP3 inflammasome activation induced by impaired protein clearance.The results of this study reveal that hydroquinone elevated the activity of NADPH oxidase which subsequently mediated the production of reactive oxygen species (ROS) and predisposed RPE cells to degeneration by reducing levels of vascular endothelial growth factor (VEGF) and pigment epithelium‐derived factor (PEDF). Hydroquinone induced an NLRP3‐independent IL‐18 release and NLRP3 accumulation inside the IL‐1α‐primed cells. Resvega treatment reduced the extent of hydroquinone‐induced ROS production and NLRP3 inflammasome activation evoked by impaired protein clearance. Thus, Resvega alleviated hydroquinone‐ and impaired protein clearance‐induced stress in human RPE cells, but more studies are needed, for example, to reveal the most optimal route of administration for targeting the cells in the retina, since both oxidative stress and NLRP3 inflammasome activation are important contributors to the development of AMD and represent significant treatment targets.

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“…A meta-analysis of 39 population-based studies found that AMD was associated with an overall prevalence of 8.69% [ 4 ]. Moreover, according to a retrospective study review conducted in Spain of 8,504 participants, AMD was present in 7.6% of the population [ 9 ]. In addition, cross-sectional studies conducted in Egypt and Korea found AMD to be similarly prevalent, at 6.6% and 6.62%, respectively [ 10 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most patients in our study had dry AMD, followed by wet AMD, and the rest had both. Similarly, a Spanish study found that dry AMD is more prevalent than wet AMD [ 9 ]. However, the prevalence of wet AMD is twice as high as that of dry AMD in some other studies [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 2014, a meta-analysis of 39 studies, including 129,664 individuals, found that the prevalence of AMD was 8.69% [ 4 ]. A retrospective study conducted in Spain among 119,877 individuals showed that the prevalence of AMD was 7.6% [ 9 ]. Slightly lower percentages were found in Korea and Germany, 6.62% and 3.3% respectively [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Associated Risk Factors of Age-Related Macular Degeneration in the Retina Clinic at a Tertiary Center in Makkah Province, Saudi Arabia: A Retrospective Record Review

Abusharkh¹,

Kurdi²,

Shigdar³

et al. 2023

Cureus

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Background Age-related macular degeneration (AMD) is a progressive disease involving the macular region of the retina and is considered a significant cause of vision loss worldwide. With the increase in life expectancy in various countries, this problem has become more apparent. We retrospectively evaluated the prevalence of AMD among patients visiting the retina clinic at King Abdulaziz University Hospital (Jeddah, Makkah Province, Saudi Arabia) to identify the commonly associated risk factors of AMD. Methods The records of 3,067 individuals from 2017 to 2021 were reviewed. Of these, 1,935 were enrolled in the study. Results The prevalence of AMD among the patients was 4%. Regarding non-modifiable risk factors, age and having a family history of AMD showed a significant association (p = 0.001 and 0.043, respectively). However, sex and nationality were not significantly associated. As for modifiable risk factors, smoking and hypertension demonstrated a significant relationship (p < 0.001 and p = 0.002, respectively). However, the association with diabetes mellitus and dyslipidemia was not significant. Conclusion Our study shows that AMD is widely prevalent in Saudi Arabia and is associated with age, family history, smoking, and hypertension. Therefore, patients at risk of AMD must be screened and managed promptly before disease progression.

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Prevalence of age-related macular degeneration among optometric telemedicine users in Spain: a retrospective nationwide population-based study

Cited by 11 publications

References 30 publications

Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration

Real-World Performance of a Self-Operated Home Monitoring System for Early Detection of Neovascular Age-Related Macular Degeneration

Regulation of oxidative stress and inflammatory responses in human retinal pigment epithelial cells

Prevalence and Associated Risk Factors of Age-Related Macular Degeneration in the Retina Clinic at a Tertiary Center in Makkah Province, Saudi Arabia: A Retrospective Record Review

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