Prevalence of Alcoholic Fatty Liver Disease Among Adults in the United States, 2001-2016

Wong, Terrence; Dang, Katherine; Ladhani, Sanah; Singal, Ashwani K.; Wong, Robert J.

doi:10.1001/jama.2019.2276

Cited by 134 publications

(102 citation statements)

References 7 publications

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“…1 B). 8 In some regions of China, the prevalence of fatty liver disease was 5.32%, and was significantly higher in males than females, with this figure rising to 10% in alcohol users. 9 NAFLD prevalence was higher than AFLD but NAFLD prevalence experienced incremental increases with alcohol consumption.…”

Section: Prevalence Of Fatty Liver Diseasementioning

confidence: 99%

Beneficial effects of Chinese herbs in the treatment of fatty liver diseases

Panyod

Sheen

2020

Journal of Traditional and Complementary Medicine

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Eating habits and lifestyle directly impact general health. Consumption of fat- and sugar-rich foods and alcohol increase the risk of developing fatty liver disease. The prevalence of fatty liver disease is markedly critical, and its pathogenesis and progression are complicated. Chinese herbal medicine has been used to treat and prevent human diseases through-out history, and is a rich source of biologically active substances with unique curative properties. More recently, Chinese herbs and their extracts have been identified as a novel source of potential therapeutic agents in the prevention and treatment of fatty liver disease. Beneficial effects of these herbal medicines mean that they can be classified as novel candidates for the treatment and prevention of both alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD), in place of conventional allopathic treatments. In this review, we explore the current literature related to herbal medicines used for the treatment of or protection against fatty liver diseases and describe their mechanisms of action.

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Section: Prevalence Of Fatty Liver Diseasementioning

confidence: 99%

Beneficial effects of Chinese herbs in the treatment of fatty liver diseases

Panyod

Sheen

2020

Journal of Traditional and Complementary Medicine

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“…2 The prevalence of hepatic fibrosis has increased among adults over the last decade. 3 This increase underscores the predictable contributions of liver fibrosis as a risk factor for long-term negative health consequences and mortality. [4][5][6] Liver fibrosis is conventionally diagnosed with liver biopsy, imaging, and transient elastography (FibroScan(®), TE, France).…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive fibrosis markers are associated with mortality risk in both general populations and non‐alcoholic fatty liver disease patients

Mao

Liu

Shi

et al. 2020

Hepatology Research

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Aim: We assessed the correlations between non invasive fibrosis scores and mortality in both the general population and non alcoholic fatty liver disease (NAFLD) patients. Methods: We used data from the US National Health and Nutrition Examination Survey 1988-2014. The NAFLD fibrosis score (NFS), Fibrosis 4 index (FIB 4) score, aspartate aminotransferase to platelet ratio index (APRI) score, and Forns index score were calculated at baseline. The associations of these scores with the risk of mortality were determined using additive Cox proportional hazard models. The area under the receiver operating characteristic curve (AUROC) was used to study the predictive capacity of each scoring system. Results: A total of 44508 participants were included; among them, 9721 deaths occurred during a mean follow up of 12.5 years. A "J" shaped correlation pattern was observed for both the FIB 4 and APRI scores. A "U" shaped correlation pattern was observed for both the Forns index and NFS. Similar correlation patterns were observed in 1955 NAFLD patients. For overall mortality, the AUROC values of the selected fibrosis scores were comparable between general population and NAFLD patients. The superior predictive capacity was found for FIB 4, with AUROC of 75.03% (95% confidence interval, 70.91% to 79.82%) in general population and 75.32% (95% confidence interval, 69.43% to 80.11%) in NAFLD patients, respectively. Conclusions: Non linear associations were shown between the fibrosis scoring systems and mortality risk. These scores could serve as indicators for mortality in people with or without NAFLD.

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“…Alcohol-associated liver disease (ALD) and nonalcoholic steatohepatitis (NASH) have emerged as significant clinical and economic health care burdens. 1,2 Lack of effective therapies for ALD and NASH contribute to increasing disease severity among patients with these diseases, leading to cirrhosis and end-stage liver disease requiring liver transplantation (LT). In this cohort study, we updated assessments of liver disease etiology trends among adults awaiting LT in the United States.…”

Section: Introductionmentioning

confidence: 99%