Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Park, Seung Ha; Kim, Chang Hoon; Kim, Dong Joon; Park, Jong Ha; Kim, Tae Oh; Yang, Sung Bong; Moon, Young Soo; Kim, Tae Nyun; Kim, Hyun Kuk; Park, Ha Young; Lee, Jung Goo; Lee, Heon Young

doi:10.3109/10826084.2011.620053

Cited by 19 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In China, alcohol abuse has been considered the second leading cause of liver disease (2). A similar trend of alcohol consumption-associated burden of disease, in particular ALD, has also been seen in Korea (3,4), as well as in Japan (5,6).…”

Section: Introductionmentioning

confidence: 82%

Improvement of liver function by the administration of oyster extract as a dietary supplement to habitual alcohol drinkers: A pilot study

Osaki

Shimizu²,

Yamamoto³

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Alcoholic liver disease (ALD) is characterized by elevated serum γ-glutamyltransferase (GGT) activity with hepatic steatosis, hepatitis or occasionally fibrosis that may progress to cirrhosis. The potential therapeutic role of oyster extract (OE) or OE-containing dietary supplements (OE supplement) in ALD has seldom been evaluated. In the present study, 84 adults who had an alcohol-drinking habit and marginally high serum GGT levels were enrolled in a randomized, double-blind, placebo-controlled feeding trial to study the effect on alcohol-impaired liver function as reflected by an increased serum level of GGT, as well as the safety, of an OE supplement. The subjects were randomized to receive either an OE supplement (OE group) or placebo (placebo group). There were 42 subjects (31 males and 11 females) in each group, and all the enrolled subjects entered the study. Four individuals (5%) dropped out for reasons unassociated with the study and 6 other subjects were excluded from the efficacy analysis because they did not maintain the required frequency of alcohol intake. As a result, 38 subjects in the placebo group and 36 in the OE group underwent efficacy assessment. Assays of GGT and other liver enzymes were performed at baseline (week 0) and at weeks 4, 8 and 12 of the intervention period. The mean serum levels of GGT in the placebo group gradually increased, while those in the OE group tended to decrease, although no significant within-group differences were observed for either group. A significant between-group difference in the change of mean GGT from baseline was, however, found at week 12 (P=0.049). No OE supplement-associated untoward side-effects nor any abnormal changes in routine laboratory tests and anthropometric parameters were observed throughout the 12-week intervention. An OE supplement shows promise in reducing risk factors associated with ALD in adults with an alcohol intake habit.

show abstract

Section: Introductionmentioning

confidence: 82%

Improvement of liver function by the administration of oyster extract as a dietary supplement to habitual alcohol drinkers: A pilot study

Osaki

Shimizu²,

Yamamoto³

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…We defined significant alcohol consumption based on the threshold of ≥210 g/week (men) and ≥140 g/week (women) and discriminated between NAFLD and AFLD accordingly (15). A standard drink was defined as having 10 g of ethanol, which comprises 150 mL of wine, 200 mL of beer, 50 mL of spirit, or 50 mL of Soju, the most popular alcoholic beverage among Koreans 14. The total amount of alcohol consumed per week on average was obtained by multiplying the weekly frequency ((a) 7 for once daily (b) 5.5 for 5-6 times per week (c) 3.5 for 3-4 times per week (d) 1.5 for 1-2 times per week (e) 0.75 for 2-3 times per month (f) 0.25 for less than once a month) by the consumption amount on a single occasion, at 10 g per drink.…”

Section: Methodsmentioning

confidence: 99%

“…Excess alcohol increases CVD risk because the beneficial increase in high-density lipoprotein cholesterol (HDL-C) is offset by increased blood pressure levels 13. However, despite its high prevalence and the substantial side effects involved, there has been limited research into AFLD not only in Korea but also on the international level 14. Alcohol is a causal factor in 60 types of diseases and injuries and a component cause in 200 others 2.…”

Section: Introductionmentioning

confidence: 99%

Alcoholic fatty liver disease elevates estimated coronary heart disease risk to levels comparable with those of nonalcoholic fatty liver disease in the Korean population: a cross-sectional study

Kim

Choe

et al. 2014

Clin Mol Hepatol

View full text Add to dashboard Cite

Background/AimsA close relationship has been established between nonalcoholic fatty liver disease (NAFLD) and an elevated risk of coronary heart disease (CHD), but little is known about the association between alcoholic fatty liver disease (AFLD) and CHD risk. The aim of this study was to determine whether AFLD is associated with elevated CHD risk.MethodsWe retrospectively enrolled 10,710 subjects out of 11,469 individuals who visited the Konkuk University Health Care Center for a routine health checkup in 2010. AFLD was diagnosed made when the usual amount of alcohol consumption exceeded 210 g/week in males and 140 g/week in females for the previous 2 years and when hepatic steatosis was detected by liver ultrasonography. The 10-year risk for CHD was estimated using the Framingham Risk Score.ResultsHepatic steatosis was diagnosed in 4,142 of the 10,710 individuals (38.7%); the remainder (i.e., n=6,568) became the control group. The 4,142 individuals with hepatic steatosis were divided into two groups: NAFLD (n=2,953) and AFLD (n=1,189). The risk of CHD was higher in AFLD (6.72±0.12) than in the control group (5.50±0.04, P<0.001), and comparable to that in NAFLD (7.32±0.07, P=0.02).ConclusionsIndividuals with AFLD have an elevated 10-year risk of CHD that is comparable to those with NAFLD. Therefore, AFLD should be considered a significant risk for future CHD, and preventive measures should be considered earlier.

show abstract

“…Although there have been no official reports regarding the prevalence of ALD and the proportion of alcohol-related causes for liver cirrhosis in Korea, studies based on inpatient data found 25-30% cases of liver cirrhosis have an alcoholic etiology 13,14. According to recent Korean studies based on data from the 2009 KNHANES, approximately 7% of Korean adults are heavy alcohol consumers (men: >40 g/day, women: >20 g/day),15,16 and approximately 25% of these heavy alcohol consumers exhibit abnormal liver-function test results 16. Since most cases of ALD occur in patients with alcohol use disorder, a brief discussion thereof is presented in the following section.…”

Section: Epidemiologymentioning

confidence: 99%

KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease

2013

Clin Mol Hepatol

View full text Add to dashboard Cite

Prevalence of Alcoholic Liver Disease Among Korean Adults: Results From the Fourth Korea National Health and Nutrition Examination Survey, 2009

Abstract: ALD is still a burden in the Korean population.

Cited by 19 publications

References 26 publications

Improvement of liver function by the administration of oyster extract as a dietary supplement to habitual alcohol drinkers: A pilot study

Improvement of liver function by the administration of oyster extract as a dietary supplement to habitual alcohol drinkers: A pilot study

Alcoholic fatty liver disease elevates estimated coronary heart disease risk to levels comparable with those of nonalcoholic fatty liver disease in the Korean population: a cross-sectional study

KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease

Contact Info

Product

Resources

About