Prevalence of allergy‐related symptoms in Singaporean children in the second year of life

Tan, Teng Nging; Lim, Dawn; Lee, Bee Wah; Bever, Hugo P. Van

doi:10.1111/j.1399-3038.2005.00242.x

Cited by 25 publications

(10 citation statements)

References 40 publications

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“…The latter is in agreement with a cross-sectional epidemiological study involving 12,323 students in Singapore (7-, 12- and 16-year age groups) reporting a prevalence of AD of 20.8% [13], an incidence markedly higher than that reported in younger age groups [14,15]. The increasing prevalence and severity of AD is concerning and further highlights the need for improved management of this condition.…”

Section: Prevalence Of Adsupporting

confidence: 73%

Treatment of Childhood Atopic Dermatitis and Economic Burden of Illness in Asia Pacific Countries

2015

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Atopic dermatitis (AD) is a common chronic inflammatory skin condition in children. In Asia, the prevalence of AD is increasing, which is largely attributed to environmental and socioeconomic factors including family income, parental education, lifestyle and metropolitan living. Current clinical guidelines recommend a stepped approach in the management of eczema in children, with treatment steps tailored to the severity of the eczema. To address the skin barrier dysfunction, skin hydration and the application of emollients is essential. There is evidence supporting the use of bleach baths as an antimicrobial therapy against Staphylococcus aureus. In patients in whom topical treatment fails, wet wrap therapy may be considered as a treatment option before considering systemic therapies. In the second part of this article, the economic burden of AD is addressed. AD not only negatively impacts the child's quality of life but also that of the whole family and is associated with a burden on health-care costs and society. AD in an infant will lead to frequent additional visits to the pediatrician, to additional and partially expensive treatment costs and, in rare cases, to hospitalization. It is thus of utmost importance to define efficient strategies to not only treat AD but also to decrease the risk of developing the disease.

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Section: Prevalence Of Adsupporting

confidence: 73%

Treatment of Childhood Atopic Dermatitis and Economic Burden of Illness in Asia Pacific Countries

2015

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“…The ISAAC studies which used the same validated questionnaire also showed a wide variation of rhinitis globally [14]. The studies from Singapore show that the prevalence of rhinitis in preschoolers is substantial with prevalence of 25.3% in the 4 to 6 year age group [15] and a cumulative prevalence of 42.7% in the 2 year age group [16]. These rates are in fact comparable with that reported in the phase III of the ISAAC with rhinitis rates reported at 25.5% for Singapore schoolchildren 6-7 years old [17].…”

Section: Introductionmentioning

confidence: 99%

Rhinitis in children less than 6 years of age: current knowledge and challenges

Hardjojo

Bever

Lee

2011

Asia Pacific Allergy

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Rhinitis is a disease of the upper airway characterized by runny and/or blocked nose and/or sneezing. Though not viewed as a life threatening condition, it is also recognized to impose significant burden to the quality of life of sufferers and their caretakers and imposes an economic cost to society. Through a PubMed online search of the literature from 2006 to September 2011, this paper aims to review the published literature on rhinitis in young children below the age of 6 years. It is apparent from epidemiology studies that rhinitis in this age group is a relatively common problem. The condition has a heterogenous etiology with classification into allergic and non-allergic rhinitis. Respiratory viral infections may play a role in the pathogenesis of long standing rhinitis, but definitive studies are still lacking. Treatment guidelines for management are lacking for this age group, and is a significant unmet need. Although the consensus is that co-morbidities including otitis media with effusion, adenoidal hypertrophy and asthma, are important considerations of management of these children. Pharmacotherapy is limited for young children especially for those below the age of 2 years. This review underscores the lack of understanding of rhinitis in early childhood and therefore the need for further research in this area.

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“…Another study found that atopic dermatitis affected 20.8% of Singaporean school children [10]. In fact, symptoms related to allergy were found to be already prevalent at a younger age, with a significant 42.2% of a cohort having had chronic itchy skin, wheeze or rhino-conjunctivitis by 24 months of life [11]. The high prevalence of allergy comes with an economic burden, with the total healthcare cost of asthma alone in Singapore estimated to be US$33.93 million per annum [12].…”

Section: Introductionmentioning

confidence: 99%

The methodology of the GUSTO cohort study: a novel approach in studying pediatric allergy

Soh

Lee

Hoon

et al. 2012

Asia Pacific Allergy

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Growing Up in Singapore Towards healthy Outcomes (GUSTO) is Singapore's largest birth cohort study to date. The main aim of GUSTO is to evaluate the role of developmental factors in the early pathways to metabolic compromise. Detailed data is collected for a range of environmental exposures in the parents and offspring, and allergic disorders are among a number of outcomes assessed in infancy and childhood. Under the Allergy domain of GUSTO, this integrated study will describe the epidemiology of allergic manifestations and different phenotypes in the Asian context and help shed light on the association of metabolic disease to allergy. Epigenetic mechanisms and associations with other childhood disorders will also be explored. The aim of this report is to focus on methodology of GUSTO, and to suggest similar approaches (i.e., integrated cohort studies on pediatric allergy) worldwide. Recruitment commenced in 2009 with a cohort of 1,163 pregnant mothers in their first trimester. The mothers and children were followed throughout pregnancy and follow-up will continue until the child reaches 3 years of age. Preliminary results showed that 39.8% of the mothers had a personal history of having at least one allergic disease, which included asthma, eczema and allergic rhinitis. Further data collection and analyses are still ongoing. Allergy is a complex spectrum of disorders with numerous poorly-understood aspects. The ongoing GUSTO cohort study, with its longitudinal design and multi-disciplinary nature, may provide new insights into developmental influences on allergy. As a Singapore-based study, it will be the first integrated allergy cohort in Southeast Asia, of which recruitment started during pregnancy.

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Prevalence of allergy‐related symptoms in Singaporean children in the second year of life

Cited by 25 publications

References 40 publications

Treatment of Childhood Atopic Dermatitis and Economic Burden of Illness in Asia Pacific Countries

Treatment of Childhood Atopic Dermatitis and Economic Burden of Illness in Asia Pacific Countries

Rhinitis in children less than 6 years of age: current knowledge and challenges

The methodology of the GUSTO cohort study: a novel approach in studying pediatric allergy

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