Prevalence of Amphistomes and Fasciola in large ruminants reared by smallholders in Lampung and Banten Provinces, Indonesia

Martindah, Eny; Sawitri, Dyah Haryuningtyas; Wardhana, April Hari; Ekawasti, Fitrine

doi:10.14202/vetworld.2023.2104-2109

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…The infection can progress from the rumen to the abomasum and small intestine. Ruminants are at risk from this disease [3][4][5][6]. Livestock is commonly infected by Paramphistomum cervi, Paramphistomum ichikawai, Paramphistomum gotoi, and Paramphistomum scotiae.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in silico study on the seeds of Veitchia merrillii on trematode worms

Athaillah,

Hambal,

Vanda

et al. 2024

Vet World

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Background and Aim: The potential of plants as anthelmintics is very large, but there is still very little research conducted in the search for effective, safe, easily obtained, and affordable anthelmintic candidates. Palem putri (Veitchia merrillii) is an ornamental plant that is interesting to study because it is included in the areca nut group which is reported to have strong abilities as anthelmintics. The study aims to evaluate the anthelmintic efficacy of Veitchia merrillii against trematode worms such as Paramphistomum spp. and Fasciola hepatica. Materials and Methods: This research employs both in vitro and computational techniques. An anthelmintic in vitro test was carried out on Paramphistomum spp. worms at concentrations of 10%, 25%, and 40% (gr/v), assessing mortality index as the observable outcome, followed by a histopathological investigation of the deceased worms for tissue and cellular damage evaluation. Seventeen compounds from V. merrillii seeds were studied in silico for their anthelmintic activity against F. hepatica worms using the quantitative structure-activity relationship technique, molecular docking, and Lipinski’s rule analysis for orally administered medication. Results: About 25% and 40% extracts of V. merrillii damaged the tegument organs in the worms. Seventeen compounds in V. merrillii seed extract, on average, yielded a higher anthelmintic index on F. hepatica than praziquantel. Eleven of the 17 compounds exhibit stronger affinity than praziquantel, with routine and gallic acid being the top two ligands (ΔGbinding values: −11.65 kcal/mol and −11.07 kcal/mol, respectively). According to Lipinski’s rule analysis, only routine compounds cannot be orally administered. Conclusion: The seeds of V. merrilli have potential as an anthelmintic agent for Paramphistomum spp. at concentrations of 25%–40% (gr/v). Keywords: Molecular docking, QSAR, Trematoda, Veitchia merillii.

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Section: Introductionmentioning

confidence: 99%

In vitro and in silico study on the seeds of Veitchia merrillii on trematode worms

Athaillah,

Hambal,

Vanda

et al. 2024

Vet World

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Prevalence of gastrointestinal parasites in cattle in Indonesia: A meta-analysis and systematic review

Ninditya,

Ekawasti,

Prastowo

et al. 2024

Vet World

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Background and Aim: Gastrointestinal parasites (GIPs) pose a major health challenge for cattle in Indonesia. GIP infections affect the production and reproductive performance of cattle, resulting in economic losses. However, the prevalence and distribution of infections have not been comprehensively profiled at the national level. This study aimed to estimate the prevalence of GIP infections in cattle in Indonesia. Materials and Methods: Overall, 667 articles were identified from six databases in English and Bahasa Indonesia. After removing duplicates and screening titles and abstracts based on the inclusion criteria (i.e., GIP prevalence in cattle in Indonesia), 67 articles were included in the data review. Data were pooled using a random-effects model in STATA software. Heterogeneity was tested using Cochran’s Q-value and I2 statistics, whereas publication bias was assessed using Egger’s regression test. Results: The overall pooled prevalence of GIP in Indonesia was 46% (95% confidence interval 37%–55%), with a total population of 17,278 cattle screened. The I2 value was 99.59%, Cochran’s Q-value was 15,957.25, and p = 0.001. The results of the regional meta-analysis based on the provinces in the three zones of Indonesia showed estimated prevalence rates of 54.0%, 52.7%, and 53.7% in Western, Central, and Eastern Indonesia, respectively. The parasite with the highest prevalence was Eimeria spp. (37.7%), followed by nematodes (34.4%) and trematodes (Fasciola spp., 21.4%). Conclusion: The findings reveal a high prevalence of GIPs in cattle across Indonesia, with significant variability across regions and parasite types. Eimeria spp., nematodes, and trematodes represent the most prevalent infections and underscore the urgent need for region-specific control strategies, including improved livestock management practices, routine screening, and integrated parasitic control programs. Keywords: cattle, gastrointestinal, Indonesia, parasites, prevalence.

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Prevalence of Amphistomes and Fasciola in large ruminants reared by smallholders in Lampung and Banten Provinces, Indonesia

Cited by 2 publications

References 27 publications

In vitro and in silico study on the seeds of Veitchia merrillii on trematode worms

In vitro and in silico study on the seeds of Veitchia merrillii on trematode worms

Prevalence of gastrointestinal parasites in cattle in Indonesia: A meta-analysis and systematic review

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