Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Mehta, Paul; Kaye, Wendy; Bryan, Leah; Larson, Theodore; Copeland, Thomas E.; Wu, Jennifer; Muravov, Oleg; Horton, D. Kevin

doi:10.15585/mmwr.ss6508a1

Cited by 121 publications

(116 citation statements)

References 44 publications

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“…First, we estimated a prevalence of ALS at 5.09 per 100,000 inhabitants, (i.e., within the range indicated in the literature [5–5.4] [9, 14]), and a crude incidence at 1.12 per 100,000 person/years (95% CI 0.85–1.48), an interval containing the incidence estimated by Pradas et al [12], for Catalonia (1.4 per 100,000 inhabitants). Second, the male/female ratio in the incidence in our sample was only slightly less than that reported in the literature [15, 10, 12] (1.25 vs. 1.3–1.5 respectively). The mean age of the cases was 63.22 years and the median age was 65 years.…”

Section: Discussioncontrasting

confidence: 85%

“…Geographic variability also occurs. The highest figures are reported for Japan: 9.9 per 100,000 inhabitants in 2013 [13], practically twice as many as in the United States (3.9 per 100,000 inhabitants in 2010–2011 [13], 4.3 in 2013 [15]) and Europe (4.06 per 100,000 inhabitants in western Europe [5]), both with fairly similar prevalence. Pradas et al [12] estimate a prevalence of 5.4 per 100,000 inhabitants for Catalonia, Spain.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence for men is between 1.3 and 1.5 higher than that of women [15, 10, 12]. ALS is rare before the age of 40 years, with the mean age at onset ranging from 58 to 63 years for the sporadic form and 40 to 60 years for the familial form [9].…”

Section: Introductionmentioning

confidence: 99%

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Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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Background: It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent. Our objective here was to investigate the association between long-term exposure to environmental factors and the occurrence of ALS in Catalonia, Spain, and to provide evidence that spatial clusters of ALS related to these environmental factors exist. Methods: We carried out a nested case-control study constructed from a retrospective population-based cohort, covering the entire region. Environmental variables were the explanatory variables of interest. We controlled for both observed and unobserved confounders. Results: We have found some spatial clusters of ALS. The results from the multivariate model suggest that these clusters could be related to some of the environmental variables, in particular agricultural chemicals. In addition, in high-risk clusters, besides corresponding to agricultural areas, key road infrastructures with a high density of traffic are also located. Conclusion: Our results indicate that some environmental factors, in particular those associated with exposure to pesticides and air pollutants as a result of urban traffic, could be associated with the occurrence of ALS.

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Section: Discussioncontrasting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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“…105400) is the most prevelant motor neuron disease, with a prevalence of 3.9 cases per 100,000 individuals (Mehta et al 2014). A devastating adult-onset disease, it impacts motor neurons in the motor cortex and spinal cord, leading to paralysis and death.…”

Section: Modeling Rna-based Mechanisms Of Toxicity Of Als/ftd In the Flymentioning

confidence: 99%

Drosophila as an In Vivo Model for Human Neurodegenerative Disease

2015

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With the increase in the ageing population, neurodegenerative disease is devastating to families and poses a huge burden on society. The brain and spinal cord are extraordinarily complex: they consist of a highly organized network of neuronal and support cells that communicate in a highly specialized manner. One approach to tackling problems of such complexity is to address the scientific questions in simpler, yet analogous, systems. The fruit fly, Drosophila melanogaster, has been proven tremendously valuable as a model organism, enabling many major discoveries in neuroscientific disease research. The plethora of genetic tools available in Drosophila allows for exquisite targeted manipulation of the genome. Due to its relatively short lifespan, complex questions of brain function can be addressed more rapidly than in other model organisms, such as the mouse. Here we discuss features of the fly as a model for human neurodegenerative disease. There are many distinct fly models for a range of neurodegenerative diseases; we focus on select studies from models of polyglutamine disease and amyotrophic lateral sclerosis that illustrate the type and range of insights that can be gleaned. In discussion of these models, we underscore strengths of the fly in providing understanding into mechanisms and pathways, as a foundation for translational and therapeutic research.

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“…21 A recently published analysis of registry data found the prevalence of ALS in the United States to be 3.9 cases per 100 000 people. 21 Limitations of the National ALS Registry include the possibility of underascertainment and the inability to calculate ALS incidence (because the date of onset is missing for most cases).…”

Section: Examples Of Environmental Health Registriesmentioning

confidence: 99%

Considerations Before Establishing an Environmental Health Registry

et al. 2015

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Public health registries can provide valuable information when health consequences of environmental exposures are uncertain or will likely take long to develop. They can also aid research on diseases that may have environmental causes that are not completely well defined. We discuss factors to consider when deciding whether to create an environmental health registry. Those factors include public health significance, purpose and outcomes, duration and scope of data collection and availability of alternative data sources, timeliness, availability of funding and administrative capabilities, and whether the establishment of a registry can adequately address specific health concerns. We also discuss difficulties, limitations, and benefits of exposure and disease registries, based on the experience of the Agency for Toxic Substances and Disease Registry.

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Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Cited by 121 publications

References 44 publications

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

Drosophila as an In Vivo Model for Human Neurodegenerative Disease

Considerations Before Establishing an Environmental Health Registry

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