Prevalence of Anal High-Risk Human Papillomavirus Infections Among HIV-Positive and HIV-Negative Men Who Have Sex With Men in Nigeria

Nowak, Rebecca G.; Gravitt, Patti E.; He, Xin; Ketende, Sosthenes; Dauda, Wuese; Omuh, Helen; Blattner, William A.; Charurat, Manhattan

doi:10.1097/olq.0000000000000431

Cited by 41 publications

(60 citation statements)

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“…Data on demographics, sexual behaviors, HIV and sexually transmitted infections (STIs) among Nigerian men who have sex with men (MSM) were previously collected [20, 21]. The prevalence of high-risk human papillomavirus (HR-HPV) was characterized in a subset of 165 participants [22]. After HPV testing, seven samples had insufficient volume and 28 failed the 16S rRNA amplification criteria of 1000 reads, leaving a final sample size of 130 for the rectal microbiota analysis.…”

Section: Methodsmentioning

confidence: 99%

Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria

Nowak

Bentzen

Ravel

et al. 2017

Aids

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Objective Untreated advanced HIV infection alters the gut microbiota, but it is unclear whether antiretroviral therapy (ART) reverses these changes. We compared the composition of the rectal microbiota among three groups of men who have sex with men (MSM): HIV-uninfected, untreated HIV, and ART-treated HIV-infected. Design A cross-sectional study was conducted among 130 MSM (55 HIV-uninfected, 41 untreated HIV, 34ART-treated HIV) in Abuja, Nigeria. Methods Bacterial 16S rRNA genes were amplified from rectal swabs, sequenced and clustered into Genera-level operational taxonomic units. Alpha diversity was quantified using the Shannon Index and compared among groups using the Kruskal-Wallis test; Associations with other scale variables were quantified using Spearman's Rank Correlation (Rs). The relative abundance of the top 15 taxa was compared according to HIV infection/treatment status using the Wilcoxon-Rank sum test. Results HIV treated MSM had a decrease in a commensal phylum, Bacteroidetes (p<0.01). Alpha diversity was positively correlated with viral loads (Rs=0.32, p<0.01). Statistically significant shifts in relative abundance of rectal microbiota for the HIV treated group included a decrease in the most abundant bacteria, Prevotella (p=0.02) and an increase in pathogenic bacteria, Peptoniphilus (p=0.04), Finegoldia (p=0.01), Anaerococcus (p=0.03), and Campylobacter (p=0.03) as compared to the other groups. Conclusions Untreated HIV infection does not significantly alter the rectal microbiota, whereas prior treatment is associated with a shift towards a more pathogenic pattern of microbiota. Treatment with an antibiotic, co-trimoxazole, in conjunction with ART may have contributed to this shift.

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Section: Methodsmentioning

confidence: 99%

Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria

Nowak

Bentzen

Ravel

et al. 2017

Aids

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Section: Human Papillomavirus (Hpv) Infection Contributes To Most Anamentioning

confidence: 99%

“…The persistent anal HPV infections have been particularly found in high-risk HPV types, which are the predominant risk factors for anal cancer 12,13 . Thus, HIV infection is considered one of the most important independent risk factors for high-risk anal HPV infection [14][15][16][17] .first amplified using polymerase chain reaction. Then, the nucleic acid was hybridized to identify 37 anal HPV DNA genotypes, including high-risk types (16,18,26,31,33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66,11, 40, 42, 54, 61, 70, 72, 81 and CP6108) 34 .…”

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confidence: 99%

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Hang

Strong

et al. 2020

Sci Rep

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Human papillomavirus (HpV) infection contributes to most anal cancers and premalignant intraepithelial lesions. this study investigated anal HpV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviorswere collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HpV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27-3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HpV vaccine.Human papillomavirus (HPV) is an important cause of sexually transmitted diseases worldwide and is associated with malignant transformations in the squamous epithelium of the anus 1 . A rising trend in the incidence of anal cancer has been shown in recent years, increasing from 0.8 per 100,000 person-years in 1975 to 1.8 per 100,000 person-years in 2014 in the United States 2 . The development of anal cancer or pre-cancerous lesions is associated with one's lifetime number of sexual partners, human immunodeficiency virus (HIV) infection, receptive anal intercourse and anal HPV infection, particularly infection with HPV16 3-5 . Moreover, among individuals with anal cancer, nearly 90% of cases are attributable to HPV infection 6 . A recent meta-analysis also showed that the increased prevalence of HPV is associated with the severity of abnormal anal cytology 7 .The incidence of anal cancer among patients with HIV infection is much higher than among the general population (51.4 versus 1.2 per 100,000 person-years) 8 . HIV infection may attenuate the host's immune competence, which then worsens the control of anal HPV infections 9-11 . In addition, HIV seropositives have a decreased probability of clearing anal HPV infection and have prolonged anal HPV infections, compared to HIV seronegatives 11 . The persistent anal HPV infections have been particularly found in high-risk HPV types, which are the predominant risk factors for anal cancer 12,13 . Thus, HIV infection is considered one of the most important independent risk factors for high-risk anal HPV infection [14][15][16][17] .first amplified using polymerase chain reaction. Then...

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“…In Africa, the prevalence of anal HPV was 69.1% in Central Africa and 40.6% in Nigeria [49,50]. Up to 82.7% of hrHPV was reported in Central Africa out of which 52.0% were multiple infections and more prevalent among HIV-positive MSM [49].…”

Section: Prevalence Of Hpv In Malesmentioning

confidence: 99%

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

Manga¹,

Fowotade²,

Yahaya³

2019

Current Perspectives in Human Papillomavirus

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Globally, human papillomavirus (HPV) is the most common viral sexually transmitted pathogen, which is significantly associated with high morbidity and mortality in both sexes. Except those vaccinated, virtually all sexually active individuals will be infected with HPV in their lifetime. Although most HPV infections are transient, association with anogenital warts, cervical, penile, and other malignancies have been reported. HPV can be transmitted from one person to another through contact especially during sexual contact including anal, vaginal, or oral. Although HPV infection affects both males and females, its causal association with cervical cancer has made most literature to be mainly on females. In view of its sexual transmissibility and the increasing prevalence of HPV-related malignancies among males worldwide, there is need for more awareness on the infection in males. Most developed countries offer HPV vaccination for girls, but vaccine recommendations for boys are still relatively uncommon especially in developing countries where the burden of HPVrelated malignancies is still very high. The current discourse highlights the need for increased awareness on HPV vaccination among this neglected gender group.

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Prevalence of Anal High-Risk Human Papillomavirus Infections Among HIV-Positive and HIV-Negative Men Who Have Sex With Men in Nigeria

Cited by 41 publications

References 26 publications

Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria

Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria

Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

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