Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer

Abstract

Background/AimsThe purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.MethodsOne hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer who were scheduled to receive palliative chemotherapy between July 2012 and June 2014 were enrolled in this observational prospective study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9).ResultsThirty-seven patients (30.8%) had anxiety or depression with clinical significance according to HADS or PHQ-9. Multivariate analysis identified lower performance status (odds ratio [OR], 4.19; 95% confidence interval [CI], 1.22 to 14.35; p = 0.023), gastric cancer (OR, 5.39; 95% CI, 0.37 to 78.23; p = 0.018), and knowledge of advanced cancer (OR, 15.07; 95% CI, 1.80 to 125.90; p = 0.012) as significantly associated with anxiety or depression. Twenty-one patients with anxiety or depression visited the psycho-oncologic clinic. In these patients, PHQ-9 score (p = 0.008), global health status (p = 0.023), fatigue (p = 0.047), and appetite loss (p = 0.006) improved from baseline to 3 months after study enrollment.ConclusionsApproximately 30% of Korean patients with advanced gastrointestinal cancer had anxiety or depression. The prevalence of anxiety or depression was higher in patients with poor performance status, gastric cancer, or knowledge of advanced cancer. Psychiatric interventions may be effective in reducing depression and improving quality of life in cancer patients with anxiety or depression.

Factors Associated with Anxiety and Depression among Diabetes, Hypertension, and Heart Failure Patients at Dessie Referral Hospital, Northeast Ethiopia

“…In this study, the prevalence of anxiety among patients with diabetes, hypertension, and heart failure was 32% (95% CI: 27.3%-36.7%). This finding is consistent with the finding of studies conducted in Korea (30%) [16] and Brazil (33.7%) [17]. This is lower than the finding of a study conducted in three Asian countries (Cambodia, Myanmar, and Vietnam) (17%) [18].…”

Targeted literature review of the global burden of gastric cancer

“…No large longitudinal epidemiological studies assessing the humanistic burden of GC from diagnosis to death were identified in our search. Among the identified studies, five were systematic literature reviews [63–67], nine were economic analyses [18, 20, 24, 26, 33, 37, 41, 42, 68], six were randomised controlled trials [69–73], one was an observational study [74], seven were prospective cohort or case-control studies [39, 75–80], seven were cross-sectional survey studies [81–87], four were retrospective studies [88–91] and one included a retrospective analysis and a prospective cross-sectional survey [92]. Only four studies used tools specific to GC or GEJC (GC module [STO22] and oesophago-gastric [OG25] modules of European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire [EORTC-QLQ]) to assess HRQoL [78, 80, 86, 87].…”

The relationship of interpersonal sensitivity and depression among patients with chronic atrophic gastritis: The mediating role of coping styles

“…CAG brings not only physical illness, but also several psychological distresses for patients. But most researchers often focus on psychology of gastric cancer patients (Chung et al., ; Nordin & Glimelius, ) and ignore the mental health of patients with CAG.…”