Prevalence of and Factors Associated with Osteoporosis among Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys

Abstract

Background: Identifying and managing osteoporosis among cancer survivors is an important issue, yet little is known about the bone health of cancer survivors in Korea. This study was designed to measure the prevalence of osteoporosis and to assess related factors among Korean cancer survivors. Materials and Methods: This study was designed as a cross-sectional analysis. Data were obtained from dual energy X-ray absorptiometry measurement of the lumbar vertebrae and femoral neck, and from standardized questionnaires among 556 cancer survivors and 17,623 non-cancer controls who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (2008-2011). We calculated adjusted proportions of osteoporosis in non-cancer controls vs. cancer survivors, and we performed multivariate logistic regression analysis. Results: The prevalence of osteoporosis among cancer survivors was significant higher than that of the non-cancer controls after adjusting for related factors. Furthermore, osteoporosis among cancer survivors was higher in elderly subjects (60-69 years : adjusted odds ratio (aOR) 3.04, 95% CI : 1.16-8.00, ≥70 years : aOR 6.60, 95% CI 2.20-19.79), in female cancer survivors (aOR: 7.03, 95% CI: 1.88-26.28), and in a group with lower monthly income (aOR: 3.38, 95% CI: 1.31-8.71). In male cancer survivors, underweight and lower calcium intake were risk factors. Conclusions: These data suggest that the osteoporosis among cancer survivors varies according to non-oncologic and oncologic factors. Effective screening should be applied, and a sufficient and comprehensive management should be matched to individual cancer survivors early after cancer treatment.

Prevalence of osteoporosis and osteopenia among cancer patients and its risk factors: a retrospective monocentric study

“…reported a higher trend of osteopenia and osteoporosis in patients aged 50 years old or younger [ 4 ]. Another study found a higher prevalence of osteoporosis among older cancer survivors, as seen in our patients [ 5 ]. Various factors that may influence BMD in cancer patients were reported in different studies.…”

“…showed a higher prevalence of osteoporosis among older age, female gender, and lower monthly income cancer survivors. Additionally, being underweight and inadequate calcium consumption in male cancer survivors were associated with osteoporosis [ 5 ]. In our analysis, older age, chemotherapy use, and low level of vitamin D were significantly associated with the prevalence of osteoporosis and osteopenia.…”

Prevalence of Chronic Sputum and Associated Factors in Korean Adults

“…KNHANES is a cross-sectional survey that consists of a health interview, a health behavior questionnaire, a health examination, and a nutrition survey for the general population of Korea (11, 12, 13, 14). KNHANES subjects include a representative national sample of the Korean population who were selected using a complex, stratified, multistage probability cluster sampling design (12, 13, 14). Participants in KNHANES are non-institutionalized civilians.…”

Prevalence of Osteoporosis and Osteopenia among Cancer Patients and Its Risk Factors: A Retrospective Analysis at Najran Cancer Center, Saudi Arabia

“…4 In our study, the mean age of patients was 60.15± 12.26 years (range 29-83 years), and a higher prevalence of osteopenia and osteoporosis was seen in patients aged ≥ 60 years compared to ≤ 60 years and the difference was statistically significant. Other studies found a higher prevalence of osteoporosis among older cancer survivors [14,15]. In contrast, AlAmri et al reported a higher trend of osteopenia and osteoporosis in patients aged 50 years old or younger (65.6% vs. 56.4%, P = 0.001) [6].…”

“…A study by Choi et al evaluated the prevalence and osteoporosis-associated factors among 556 Korean cancer survivors and compared them to 17,623 non-cancer participants. The results showed that older age, female gender, and lower monthly income in cancer survivors were associated with a higher prevalence of osteoporosis while being underweight and inadequate calcium consumption in male cancer survivors were also linked to the condition [14]. Go groups.…”