Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary‐care Veterinary Practices in England

Mattin, Madeleine; Boswood, Adrian; Church, David; López-Alvarez, Jordi; McGreevy, Paul D.; O'Neill, D G; Thomson, Peter; Brodbelt, David

doi:10.1111/jvim.12591

Cited by 74 publications

(88 citation statements)

References 25 publications

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“…Four dogs in our study had evidence of cardiac disease, which is unsurprising because of the CKCS predisposition for mitral valve disease . Apnea has multiple consequences, such as intrathoracic pressure changes, myocardial ischemia, and inflammation, which can lead to heart failure.…”

Section: Discussionmentioning

confidence: 83%

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

2018

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Objective: To describe sleep-disordered breathing (SDB) in the Cavalier King Charles spaniel (CKCS). Study design: Retrospective case series. Animals: Five client-owned dogs referred for SDB. Methods: Medical records were reviewed including recheck appointments and routine preoperative and postoperative questionnaires. Whole-body barometric plethysmography was used to categorize SDB. Results: All dogs presented with multiple episodes of stertorous breathing, choking, and apnea during sleep. Severe nasal septal deviation, aberrant nasal turbinates, and soft palate elongation and thickening were noted on computed tomography and rhinoscopy of each dog. Whole-body barometric plethysmography measurements during sleep (in 3 dogs) documented periods of choking, snoring, and apnea. Treatment combined laser turbinectomy, folding flap palatoplasty, tonsillectomy, laryngeal sacculectomy, and cuneiform process resection. All dogs improved in terms of incidence and severity of sleep apnea within 1 week, with 4 of 5 dogs achieving complete resolution. Conclusion: The objective measurements used to characterize SDB in this population of CKCS provided some evidence to support an obstructive cause for this condition, which improved with surgical treatment. Clinical significance: Sleep-disordered breathing in the CKCS is a different clinical presentation of brachycephalic obstructive airway syndrome. Our finding of intranasal abnormalities in these 5 dogs with SDB provides justification for future research into its clinical significance.

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Section: Discussionmentioning

confidence: 83%

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

2018

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“…Despite several molecular studies that investigated its aetiopathogenesis, the exact cause of hyperadrenocorticism in most dogs remains unknown (Hanson et al, 2010, Kool et al, 2013, Teshima et al, 2009, van Rijn et al, 2010, van Wijk et al, 2014. Access to clinical health data on the large population of dogs in VetCompass offers the intriguing prospect of aetiological and epidemiological research across a range of disorders such as hyperadrenocorticism and of linking these with primary-care diagnosis and health management (Mattin et al, 2014, Kearsley-Fleet et al, 2012, Taylor-Brown et al, 2015, Mattin et al, 2015, O'Neill et al, 2013.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of hyperadrenocorticism among 210,824 dogs attending primary‐care veterinary practices in the UK from 2009 to 2014

O'Neill

Scudder

Faire

et al. 2016

J of Small Animal Practice

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Methods: Cases were identified by searching de-identified electronic patient records from UK primary-care veterinary practices participating in the VetCompass Programme.Results: The estimated prevalence for hyperadrenocorticism diagnosis in dogs was 0.28% (95% confidence interval 0.25-0.31). Multivariable logistic regression analysis revealed four associated risk factors: breed, breed-relative bodyweight, age and insurance status. The Bichon Frise had 6.5 times the odds (95% CI 3.5-12.1, P < 0.001) of hyperadrenocorticism compared with crossbreds. Dogs weighing more than or equal to their breed mean had 1.7 times odds (95% CI 1.3-2.3, P < 0.001) of hyperadrenocorticism compared with dogs weighing less than the breed mean. Dogs aged 12.0 years and above showed 5.7 times the odds (95% CI 3.7-8.7, P < 0.001) of hyperadrenocorticism compared with dogs aged 6.0-8.9 years. Insured dogs had 4.0 times the odds (95% CI 2.8-5.6, P < 0.001) of hyperadrenocorticism compared with noninsured dogs.Clinical significance: This is the first epidemiological report of a non-referral hospital population of dogs diagnosed with hyperadrenocorticism in the UK and describes important breed, age and bodyweight associations with this disorder which may improve diagnosis and enhance understanding of the underlying pathophysiology.

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“…D egenerative valve disease (DVD) usually affecting the mitral valve is the most common cardiac disease in dogs being responsible for 75-80% of all cardiac disease. 1,2 Progressive DVD with deposition of mucopolysaccharides and collagen degeneration of the mitral valve alone or in combination with the tricuspid valve leads to incompetence. This is characterized by a left apical systolic murmur, the loudness of which is related to the severity of the disease.…”

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confidence: 99%

Degenerative Valvular Disease in the Cavalier King Charles Spaniel: Results of theUKBreed Scheme 1991–2010

Swift

Baldin

Cripps

2017

Veterinary Internal Medicne

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BackgroundCavalier King Charles spaniels (CKCSs) are predisposed to degenerative mitral valve disease (DMVD) and studies have indicated a genetic cause.AnimalsA total of 8,860 CKCSs were examined at shows or private clinics from 1991 to 2010.ObjectivesTo analyze the effects of a breed scheme for CKCS on the age at which a murmur consistent with DMVD was first detected.MethodsThe presence or absence of a murmur consistent with mitral regurgitation was noted and age a murmur was first detected recorded.ResultsA total of 16,887 examinations were performed on 8,860 dogs. The median age dogs developed a murmur were slightly younger in male than female dogs (7.8 versus 8.3 years, 95% confidence interval [CI] 7.4–8.1 versus 8.0–8.4, P < .001) and cardiologists detected murmurs in younger dogs than did general practitioner (GP) veterinary surgeons (7.2 versus 8.6 years, 95% CI 7.0–7.4 versus 8.3–8.7 P < .001). In bitches examined by GP vets during the study, there was a significantly increased age of detection of murmurs over time (8.6–9.2 years, 95% CI 8.3–9.1 and 8.5–10.9, P = .001) but not for male dogs examined by GP vets or dogs of either sex examined by cardiologists.Conclusions and Clinical ImportanceThis study suggests that the age incidence of murmurs associated with DMVD might be increased by application of breeding guidelines based on auscultation alone. This benefit was only seen in a subgroup and compliance of breeders with this voluntary scheme was poor.

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Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary‐care Veterinary Practices in England

Cited by 74 publications

References 25 publications

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

Epidemiology of hyperadrenocorticism among 210,824 dogs attending primary‐care veterinary practices in the UK from 2009 to 2014

Degenerative Valvular Disease in the Cavalier King Charles Spaniel: Results of theUKBreed Scheme 1991–2010

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