Prevalence of and risk factors for cognitive impairment in patients with relapsing-remitting multiple sclerosis: Multi-center, controlled trial

Özakbaş, Serkan; Türkoğlu, Recai; Tamam, Yusuf; Terzı, Murat; Taşkapılıoğlu, Özlem; Yücesan, Canan; Limoncu, Hatice; Gençer, Mehmet; Akıl, Eşref; Şen, Sedat; Turan, Ömer Faruk; Sorgun, Mine Hayriye; Yiğit, Pınar; Türkeş, Nevin

doi:10.1016/j.msard.2018.03.009

Cited by 42 publications

(17 citation statements)

References 33 publications

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“…Interestingly, it is found that people lived in smaller house (measured by the per-capita living space) were exposed to higher risk of cognitive impairment. As is known, living space is related to economic condition or income of residents, which is one of important determinants of cognitive impairment [31,33,34].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Ding¹,

Zhao²,

Wang³

et al. 2020

Journal of Global Health

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Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Ding¹,

Zhao²,

Wang³

et al. 2020

Journal of Global Health

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“…Despite the more severe conditions of ADNS with brain involvement, the burden of a lesion in the brain may modestly correlate to the development of cognitive disability and depression, which may also contribute to a poor quality of life. Taking MS as an example, and excepting the direct impact of the depressive state on the quality of life, depression, as well as fatigue, can cause deterioration in cognitive impairment and exert an indirect impact on the activities of daily living ( 83 ). However, the interactions between these factors are intricate.…”

Section: Influencementioning

confidence: 99%

“…On the one hand, a depressive condition may contribute to the development and progression of other symptoms and cause further deterioration in these disorders. Depression has also been found to influence cognition in neurological and psychiatric disorders, thus contributing to disability and disease duration ( 83 ). Fatigue is the most common physical symptom in ADNS and can be enhanced by a depressive state.…”

Section: Influencementioning

confidence: 99%

Depressive Syndromes in Autoimmune Disorders of the Nervous System: Prevalence, Etiology, and Influence

Liu

Tang

2018

Front. Psychiatry

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Autoimmune diseases of the nervous system (ADNS) consist of a group of severely disabling disorders characterized by abnormal immune attack against protein components of the nervous system. This type of attack behavior may occur in the central or peripheral nervous system, and in the neuromuscular junction, resulting in neuronal damage, axonal injury, demyelination or destruction of the neuromuscular junction. While the neurological deficits of patients with ADNS have received significant research attention, the manifestation of depression tends to be ignored. In fact, depressive manifestation is common in ADNS and adds significant burden upon patients suffering from this disease. Here, we systematically reviewed the current literature to highlight the prevalence, etiology and influence of depressive manifestation in ADNS. Most autoimmune diseases of the nervous system are discussed in this paper, from multiple sclerosis, acute disseminated encephalomyelitis and autoimmune encephalitis to acute myelitis, neuromyelitis optica, Guillain-Barré syndrome and myasthenia gravis. Depressive symptoms usually develop as a comorbidity during the course of disease, but sometimes exist as a primary presentation of the disease. Psychosocial factors, long periods of disablement and chronic pain are the three most common causes of depressive symptoms in many chronic conditions, particularly in peripheral neuropathy. Furthermore, the higher prevalence of depressive symptoms in ADNS suggests that immunological dysregulation may contribute to the elevated morbidity of depression. Finally, structural lesions of the brain, and some medications for ADNS, are also thought to precipitate depressive states in ADNS.

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“…Patients with EDSS scores ≤ 3-15 years after the onset of the disease are considered BMS (3,4). Although a relatively slow progression is observed in the somatic neurological findings of BMS patients, other nervous system functions may be severely impaired (5).…”

Section: Introductionmentioning

confidence: 99%

“…Cognitive functions are affected in the late and early stages of the disease (including clinically isolated syndrome), and impairments in the course of the disease may occur. There are many studies showing that cognitive findings deteriorate in BMS cases (5).…”

Section: Introductionmentioning

confidence: 99%

B Cell Immunophenotyping and Expression Analysis of B Cell Specific Molecules of Patients with Benign Multiple Sclerosis

Şen¹,

Akbayır²,

Türkoğlu³

et al. 2020

Experimed

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ÖZ ORIGINAL ARTICLE ORİJİNAL ARAŞTIRMAObjective: Multiple Sclerosis (MS) is a progresive and an immune mediated inflammatory central nervous disease. The focus of this study was to determine the possible relationship between B cell immunophenotypes and related gene expressions in the benign MS (BMS) group with disease and cognitive processes. Material and Method:Twenty BMS patients, 16 non-BMS and 28 healthy volunteers were included in the study. Gene expression was performed by real-time PCR (RT-PCR). Immunophenotyping of peripheral B cells was also evaluated by flow cytometry. The relationship between cognitive functions and gene expression levels and B cell subtypes was investigated.Results: It was observed that naïve (CD19 + IgD + CD27 -) cells were higher in the BMS group compared to the healthy group (HC), and memory B cells showed opposite changes. Un-switched memory B cells(CD19 + IgD + CD27 + ) were found to be higher in the benign group than in the HC. The expression of BANK and BLNK was found to be lower in both MS groups than in the HC. As a result of neuropsychological examinations and cognitive tests; it was observed that motor processes in BMS were better protected than Non-BMS.Conclusion: These findings support that B cell functions may have molecular and cellular effects, and may lead to regression in inflammation and clinical progression. Molecules showing significant changes in our study may play a role as prognostic biomarkers in MS. Amaç: Multipl Skleroz (MS), aksonal dejenerasyona, demiyelinizasyona ve inflamasyona bağlı gelişen, merkezi sinir sistemini etkileyen progresif bir hastalıktır. Bu çalışmada benign MS (BMS) grubunda periferik kan B hücre immünofenotiplerinin ve B hücresi ile ilişkili gen ekspresyonlarının hastalık ve bilişsel süreçlerle ilişkisinin araştırılması hedeflenmiştir. Gereç ve Yöntem: Yirmi BMS hastası, 16 benign olmayan MS (Non-BMS) hastası ve 28 sağlıklı gönüllü çalışmaya dahil edildi. Daha önce periferik kan hücrelerinde yapılan gen mikroarray çalışması ile gruplar arasında ekspresyonu değişikliği gözlenen genlerin validasyonu gerçek zamanlı PZR ile yapıldı. Periferik B hücrelerinin immünofenotiplemesi akım sitometrisi ile değerlendirildi. Bilişsel fonksiyonlar ile gen ekspresyon seviyeleri ve B hücre alttipleri arasındaki olası ilişki araştırıldı. Bulgular: Naif (CD19 + IgD + CD27 -) B hücrelerinin BMS grubunda sağlıklılara göre yüksek olduğu, hafıza B hücrelerinin zıt yönde değişiklik gösterdiği gözlendi. Dönüşmemiş hafıza B hücrelerinin (CD19 + IgD + CD27 + ) ise benign grupta sağlıklılara göre yüksek olduğu belirlendi. BANK ve BLNK gen ekspresyonları her iki MS grubunda da sağlıklılardan düşük olarak belirlendi. Nöropsikolojik incelemeler ve kognitif testler sonucunda, BMS'te motor süreçlerin Non-BMS'ye göre korunduğu gözlendi. Sonuç: Bu bulgular B hücresi işlevlerinin moleküler ve hücresel etkileri olabileceği ve inflamasyon ile klinik progresyonda gerilemeye yol açabileceği yönündeki görüşleri desteklemektedir. Değişiklik gösteren moleküllerin MS hastalığında pr...

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Prevalence of and risk factors for cognitive impairment in patients with relapsing-remitting multiple sclerosis: Multi-center, controlled trial

Cited by 42 publications

References 33 publications

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Depressive Syndromes in Autoimmune Disorders of the Nervous System: Prevalence, Etiology, and Influence

B Cell Immunophenotyping and Expression Analysis of B Cell Specific Molecules of Patients with Benign Multiple Sclerosis

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