Prevalence of and risk factors associated with ovine progressive pneumonia in Wyoming sheep flocks

Gerstner, Shelley; Adamovicz, Jeffrey J.; Duncan, John V.; Laegreid, William W.; Marshall, Katherine L.; Logan, James R.; Schumaker, Brant A.

doi:10.2460/javma.247.8.932

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Despite strong evidence for a consistent association between TMEM154 genotype and susceptibility to MV infection in a wide range of conditions, several authors reported some animals serologically MV positive were carriers of protective genotype [19,22,25]. Several factors may influence the proportion of seropositive sheep with this genotype, such as heterogeneity of breeds, age, and sex of animals, management systems, viral strength, the dose of exposure, route of infection, and presence of different MVV strains or subtypes [19,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility

Tumino

Tolone

Galluzzo

et al. 2022

Animals

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Maedi-visna (MV) is a disease caused by small ruminant lentiviruses. It is included in the list of notifiable terrestrial animal diseases due to economic losses and animal welfare harm in the sheep sector. To date, control programs remain the onliest approach to avoiding infection. The allelic variant p.Glu35Lys (E35K) of the TMEM154 gene has been strongly associated with host vulnerability to MV illness. The present study aimed to investigate the association of TMEM154 E35K allele frequencies with MV susceptibility in native Sicilian sheep breeds. More than 400 animals from 14 local sheep were serologically tested and genotyped for the TMEM154 E35K polymorphism. The local breeds displayed different values of MV seroprevalence, with the lowest antibody prevalence in Barbaresca and Pinzirita breeds. TMEM154 protective allele (K35) was less frequent than the risk allele (E35) in Valle del Belìce breed, whereas the other three breeds showed a more balanced alleles distribution. A positive association between seroprevalence and genotype was found in the entire sample set. The risk of infection resulted in more than 3-fold times as high in sheep with EK and EE genotype compared to the KK genotype. Our data could be helpful in establishing selection breeding programs aimed at reducing MV infection in Sicilian sheep farming and encouraging the breeding of native breeds.

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Section: Discussionmentioning

confidence: 99%

Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility

Tumino

Tolone

Galluzzo

et al. 2022

Animals

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“…However, other studies have also reported a lower prevalence [ 3 , 8 , 52 ]. In other continents, prevalence tends to be lower than in Europe [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Small Ruminant Lentivirus Infection in Sheep and Goats in North Portugal: Seroprevalence and Risk Factors

et al. 2023

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Small ruminant lentiviruses (SRLVs) are transmitted among ovine and caprine species. This disease is a severe problem for small ruminant production, not only for animals’ well-being but also for flocks’ efficiency. The main aim of this research was to quantify the seroprevalence and associated risk factors for SRLV infection in the northern region of Portugal. Samples were collected from a total of 150 flocks, of which 129 (86.0%; 95% CI: 80.67%–91.33%) had at least one seropositive animal. Out of 2607 individual blood samples, 1074 (41.2%) were positive for SRLVs. Risk factors associated with SRLV infection were species (caprine), age (>2 years old), flock size (>100 animals), production system (intensive), food production system (milk), type of activity (professional), participation in livestock competitions (yes), replacement young ewe bought (yes), and natural feeding management (yes). This knowledge empowers the implementation of effective preventive measures. Overall, biosecurity measures should be promoted and implemented with the main aim of reducing viral transmission and reducing the prevalence of this disease. We recognise that government authorities should promote and audit voluntary control and eradication programs in small ruminant flocks in the region studied.

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“…The findings in this study were also much lower than in other countries of the world. For instance, a prevalence of 19% in Canada (Simard and Morley, 1991), 15.6% in culled ewes in Alberta, Canada (Fournier et al, 2006), 50% in Palestine (Hananeh and Barhoom, 2009), 28.8% in Germany (Hüttner et al, 2010), 15.3% was reported in Turkish sheep (Preziuso et al, 2010), 19.4% in Kirikkale district, Turkey (Azkur et al, 2011), 18% in Wyoming sheep, USA (Gerstner et al, 2015) and 29.6% in Khorasan-e Razawi province, Iran (Norouzi et al, 2015). Such inconsistency (variation) in the prevalence rates of MVV might be the variation in the diagnostic tests, sampling method used, the prevalence variability within the population studied, the characteristics of the animals forming the population, susceptibility of different breeds to the disease, management practices and measures taken to control the disease.…”

Section: Discussionmentioning

confidence: 99%

Sero-prevalence and associated risk factors of Maedi-visna virus in sheep population of selected area of eastern Amhara, Ethiopia

Yizengaw¹,

Belayneh²,

Zegeye³

et al. 2020

ijah

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Maedi-visna virus (MVV) causes a significant economic loss through morbidity, mortality and carcass weight loss in sheep worldwide. This cross-sectional study was conducted to determine the prevalence and identify associations with potential risk factors of MVV virus infection in the selected area of the eastern Amhara region, Ethiopia. A total of 494 sheep blood sera were collected during the period from November, 2017 to October, 2018 and examined using Indirect enzyme linked immuno-sorbent assay (I-ELISA) to screen specific antibodies against MVV. From the total tested sample 3.24% (16/494) were positive for the presence of antibodies against MVV in the area. The sero-prevalence of MVV was not significantly different between associated risk factors of breed, sex, age, production system, flock size and body condition score (P> 0.05). Awassi cross sheep distributor farm and ranch were incriminated as a source for Maedi-visna virus infection and effective control measures should be implemented through appropriate way of testing and culling mechanisms of all seroreactor ewes and their progeny. High sensitive screening test should be practiced and implemented during introduction of new flocks from abroad and before distribution of Awassi cross breed rams from ranches and multiplication center to smallholder farms and individual farmers. In addition further epidemiological study (research) should be done in sheep producing areas of the country to know the level of infection at national and country level.

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Prevalence of and risk factors associated with ovine progressive pneumonia in Wyoming sheep flocks

Abstract: Results indicated that OPP is prevalent in many Wyoming sheep flocks, which suggested that continued efforts are necessary to increase producer knowledge about the disease and investigate practices to minimize economic losses associated with OPP.

Cited by 9 publications

References 17 publications

Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility

Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility

Small Ruminant Lentivirus Infection in Sheep and Goats in North Portugal: Seroprevalence and Risk Factors

Sero-prevalence and associated risk factors of Maedi-visna virus in sheep population of selected area of eastern Amhara, Ethiopia

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