Prevalence of anti-hepatitis E virus IgG antibodies in sera from hemodialysis patients in Tripoli, Lebanon

Ismail, Mohamad Bachar; Kassaa, Imad Al; Safadi, Dima El; Omari, Sarah Al; Mallat, Hassan; Dabboussi, Fouad; Hamzé, Monzer

doi:10.1371/journal.pone.0233256

Cited by 4 publications

(6 citation statements)

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“…In the context of investigating the utilization of various water sources, a logistic regression analysis revealed a significant association between the consumption of bottled water and a reduced probability of HEV-positive cases (OR = 0.20, 95% CI: 0.04-0.99). This finding contrasts with the observations made by researchers in Croatia and Lebanon, who did not identify a similar relationship [15,16].…”

Section: Discussioncontrasting

confidence: 99%

“…The Euroimmun was selected based on its established high specificity of 100% for anti-HEV IgM and 99.3% for anti-HEV IgG in patients lacking markers of HEV infection, as observed in our study population [14]. Additionally, other authors have utilized Euroimmun to assess the prevalence of anti-HEV among different patient groups [9,[15][16][17].…”

Section: Serological Testingmentioning

confidence: 99%

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Hepatitis E Virus (HEV) Infection among Hemodialysis Patients from Southern Bulgaria

Kevorkyan,

Golkocheva-Markova,

Raycheva

et al. 2023

Pathogens

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Viral hepatitis B and C are widely recognized problems in hemodialysis (HD) patients. There have been increasing reports of the importance of the hepatitis E virus (HEV) in recent years, but the worldwide data on the seroprevalence of HEV among them are conflicting. The aim of the present study was to assess the seroprevalence of HEV in HD patients and to analyze the predictors of seropositivity. This study was conducted in 2020 in the central part of southern Bulgaria. A total of 225 patients were enrolled. An enzyme-linked immunosorbent assay for the determination of anti-HEV IgM/IgG was used. All patients were tested for the presence of HEV RNA. Anti-HEV IgM alone and anti-HEV IgG alone were found in 6 (2.7%) and 14 (6.2%) patients, respectively, and in 4 (1.8%) patients, they were found simultaneously. All patients were HEV RNA-negative. The overall HEV seroprevalence was 10.7% (24/225). The binominal logistic regression analysis of available predictors confirmed the role of vascular access and a duration of dialysis treatment over 5 years as predictors significantly associated with increased risk for HEV, and the consumption of bottled water with lower levels of HEV IgG seroprevalence among hemodialysis patients. The accumulated data are the basis for comparative analysis in subsequent trials in the same dialysis centers and for enhancing the range of screening markers used in this particular patient group.

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Section: Discussioncontrasting

confidence: 99%

Section: Serological Testingmentioning

confidence: 99%

Hepatitis E Virus (HEV) Infection among Hemodialysis Patients from Southern Bulgaria

Kevorkyan,

Golkocheva-Markova,

Raycheva

et al. 2023

Pathogens

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“…The seroprevalence of IgG anti-HEV antibodies (12.82%) reported in our study was similar to the seroprevalence reported in Uruguay (10%) and China (13.36%) (13,29), but remarkably lower than those reported in other countries such as Sudan (56.4%), France (54.4%), Central Italy (49%), South Africa (42.8%), Nepal (41.9%), Dutch (31%) and the Netherlands (27%) (5,10,11,15,27,28,30). Recently, two studies have been conducted in Lebanon to evaluate the anti-HEV IgG seropositivity in different high-risk populations such as pregnant women and hemodialysis patients (9,31). Surprisingly, our results revealed higher anti-HEV IgG seropositivity as compared to pregnant women (0.22%), but lower than the seroprevalence reported in hemodialysis patients (21.63%).…”

Section: Discussionmentioning

confidence: 87%

“…A re-cent report in Lebanon has examined the prevalence of IgG anti-HEV antibodies in sera of hemodialysis patients in Tripoli and has indicated that only one pregnant woman was positive for HEV infection with a seropositivity rate of 0.22% (1/450). In addition, no significant exposure to HEVassociated risk factors has been reported (9).…”

Section: Introductionmentioning

confidence: 99%

Sero-epidemiology and Risk Assessment of Hepatitis E Virus Among Blood Donors in North Lebanon

Ghazzawi

Moubayed

Khalife

2022

Arch Clin Infect Dis

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Background: Hepatitis E virus (HEV) is the causative agent of over 50% of acute viral hepatitis cases. The blood transfusion route has emerged as a possible route of transmission of HEV. Objectives: This study aimed to determine the seroprevalence of IgM and IgG anti-HEV among blood donors in North Lebanon and to assess the risk factors associated with its occurrence. Methods: A cross-sectional study was conducted from November to December 2020. Blood samples were collected from 78 healthy blood donors. A standardized questionnaire containing sociodemographic, food consumption, lifestyle, and health-related characteristics, was filled out to assess the risk factors of HEV exposure. Serum samples were tested for IgM and IgG anti-HEV by an enzyme-linked immunosorbent assay (ELISA). Results: The seroprevalence of IgM and IgG anti-HEV antibodies was reported in our study, and it reached 1.09% (1/78) and 12.82% (10/78), respectively. The use of private wells as a drinking source and the travel history to endemic countries have been identified as risk factors for HEV infections (P

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“…In our analysis high prevalence of 33/84 (39.28%) of anti-HEV IgG were observed in HD patients which is in accordance with Harrison et al findings ( 28 ). Ismail et al (2019) in the Lebanon have reported 37/171 HD patients including 22/96 (22.92%) males and 15/75 (20%) females showed positivity for anti HEV IgG ( 29 ). Mrzljak et al (2020) in Croatia have described the HEV IgG antibodies was detected in 110 (27.9%) HD patients.…”

Section: Discussionmentioning

confidence: 98%

Status of anti-HEV IgG and IgM antibodies among the hemodialysis patients in southwest region of Iran

Pirmoradi¹,

Makvandi²,

Navand³

et al. 2022

IJM

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Background and Objectives: Hepatitis E Virus (HEV) account for acute hepatitis, fulminant liver failure and chronic hep- atitis worldwide. Several high riskgroups including hemodialysis (HD) patients are at risk of HEV infection. Based on con- sequences of HEV infection it is important to determine the serologicaland molecular epidemiology of HEV in HD patients. The aim of this study was to evaluate the frequency of HEV antibodies and HEV RNA in HD patients. Materials and Methods: The sera of 84 HD patients were collected and tested for anti- HEV IgG and anti IgM antibodies using enzyme-linkedimmunosorbent assay (ELISA) at Golestan hospital in Ahvaz city during October 2014 and November 2014. HEV RNA was tested in HD patients using RT PCR. The prevalence of anti- HEV IgG was evaluated in the age group (52/84) > 50 and (31/84) < 50 years. Results: Out of 84 patients, 52 (61.9%) were males and 32 (38.1%) females. The mean age of participants was 52 ± 1.57 years. 43/84 (51.19%) casesincluding 26/52 (50%) males and 17/32 (53.1%) females were positive for anti-HEV IgG (p=0.95). Among the 43 cases positive anti-HEV IgG 8 cases including 5 (9.61%) males and 3 (9.37%) females tested posi- tive for anti-HEV IgM (p=0.729) while the HEV RNA was negative in HD patients. Thedistribution of anti- HEV IgG was 62.75% and 33.33% among the age group >50 and <50 respectively (p=0.015). Conclusion: This study showed high prevalence of anti-HEV IgG antibodies (51.19%) were observed among the HD pa- tients while the HEV RNA testednegative in HD patients. The rate of HEV IgG is significantly higher with increased age. Further investigation require to identify the factors account for high seroprevalence of HEV in Ahvaz HD units.

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Prevalence of anti-hepatitis E virus IgG antibodies in sera from hemodialysis patients in Tripoli, Lebanon

Cited by 4 publications

References 50 publications

Hepatitis E Virus (HEV) Infection among Hemodialysis Patients from Southern Bulgaria

Hepatitis E Virus (HEV) Infection among Hemodialysis Patients from Southern Bulgaria

Sero-epidemiology and Risk Assessment of Hepatitis E Virus Among Blood Donors in North Lebanon

Status of anti-HEV IgG and IgM antibodies among the hemodialysis patients in southwest region of Iran

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