Prevalence of anti-sperm antibodies and relationship of degree of sperm auto-immunization to semen parameters and post-coital test outcome: a retrospective analysis of over 10 000 men

Barbonetti, Arcangelo; Castellini, Chiara; D’Andrea, Settimio; Cordeschi, Giuliana; Santucci, R.; Francavilla, Sandro; Francavilla, Felice

doi:10.1093/humrep/dez030

Cited by 39 publications

(31 citation statements)

References 31 publications

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“…Incidences of antisperm antibodies vary between 2% (Barbonetti et al, 2019) and 15% (Witkin, 1988). Higher incidences are reported in patients with genital tract infections and obstructions as well as after vasectomy and cystic fibrosis (Marconi & Weidner, 2017).…”

Section: Induc Ti On Of Antis Perm Antibod Ie Smentioning

confidence: 99%

The role of infections and leukocytes in male infertility

2020

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Oxidative stress is preempted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, such as superoxide dismutase, catalase and glutathione peroxidase, and several nonenzymatic antioxidants (pro teins, vitamins and minerals), working as oxidant scavengers and cofactors of en zymatic antioxidants have been identified in seminal plasma. The total antioxidant capacity (TAC) is a diagnostic test that can be utilised in the male infertility workup. TAC measures the amount of total antioxidants in seminal plasma. Therefore, it pro vides an assessment of the reductive potential in seminal plasma. Several studies have investigated the diagnostic application of TAC in various andrology conditions. There is substantial evidence in the literature to show that infertile patients have lower seminal TAC in comparison with fertile men. Moreover, there is a positive cor relation between TAC and seminal parameters, such as sperm concentration, motility and morphology. Evaluation of TAC together with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may be beneficial in the diagnosis of male infertility.

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Section: Induc Ti On Of Antis Perm Antibod Ie Smentioning

confidence: 99%

The role of infections and leukocytes in male infertility

2020

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“…ASA is usually IgG isotype when found in blood or lymph node, and in the form of IgA when in seminal secretions [132]. To date, the IgGmixed anti-globulin reaction (IgG-MAR) test is the most widely used test for ASA detection, with positive results ranging from 2.6% to 12.9% depending on the threshold chosen for positivity [133].…”

Section: Antisperm Antibodymentioning

confidence: 99%

Thoughts on the popularity of ICSI

Haddad

Stewart

Xie

et al. 2020

J Assist Reprod Genet

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Purpose Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility. Methods We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI. Results This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing. Conclusion The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide.

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“… 21 Moreover, some researchers reported an inverse relationship between severity of autoimmunization and sperm concentration. 29 …”

Section: Discussionmentioning

confidence: 99%

“…Although some studies supported our results regarding the negative effect of ASA on sperm motility, simply due to slowing down the sperm by joining of antibodies to the sperm tail, 28 , 30 other investigators did not find any correlation between the existence of ASA and sperm motility, 31 while a third section of researchers found this negative effect of ASAs on motility to be related to the severity of autoimmunization. 29 The heterogeneity of the localization of the targeted antigen and its relevance to motility, and the inclusion of cases with unmatched degrees of autoimmunity, may explain the discrepancy between different studies. In contrast to our results, a systematic review conducted in 2015 showed that there was no significant effect of ASA on sperm morphology.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of seminal anti-sperm antibodies screening in men prepared for ICSI: a call to change the current antibody-directed viewpoint of sperm autoimmunity testing

El‐Sherbiny

Abouelgreed

Mehaney

et al. 2021

Therapeutic Advances in Urology

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Aims: We aimed to prospectively evaluate the prognostic value of seminal anti-sperm antibodies (ASA) screening in couples prepared for intracytoplasmic sperm injection (ICSI). Methods: A prospective comparative study was conducted, including 184 non-azoospermic infertile men scheduled for ICSI. For each patient, detection of ASA in seminal plasma using the ELISA technique was done and its relation to standard semen parameters and ICSI outcomes, including fertilization, embryo development, and pregnancy rates, was analyzed. Results: Sperm count, motility, and morphology were negatively affected by existence of seminal ASA ( p = 0.012, 0.006, and 0.011, respectively). However, no statistically significant difference was detected between patients with positive and negative seminal ASA regarding the median values of fertilization (56.3% versus 66.7%, p = 0.091), percentage of couples with grade A embryo development (91.4% versus 89.9%, p = 0.520), and pregnancy rates (31.4% versus 32.2%, p = 0.98) after ICSI. Conclusion: ICSI seems able to overcome the problem of ASA in semen. The routine screening of ASA in men prepared for ICSI has no additional prognostic value and cannot be recommended for the time being, until more specific antigen-concerned testing can be developed.

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Prevalence of anti-sperm antibodies and relationship of degree of sperm auto-immunization to semen parameters and post-coital test outcome: a retrospective analysis of over 10 000 men

Cited by 39 publications

References 31 publications

The role of infections and leukocytes in male infertility

The role of infections and leukocytes in male infertility

Thoughts on the popularity of ICSI

The prognostic value of seminal anti-sperm antibodies screening in men prepared for ICSI: a call to change the current antibody-directed viewpoint of sperm autoimmunity testing

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