Prevalence of antibiotic resistance in lactic acid bacteria isolated from traditional fermented Indian food products

Ojha, Anup Kumar; Shah, Nagendra P.; Mishra, Vijendra; Emanuel, Neela; Taneja, Neetu Kumra

doi:10.1007/s10068-023-01305-1

Cited by 4 publications

(1 citation statement)

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“…Among the Enterococcus species, Enterococcus faecium is one of the most commonly encountered species in human feces, along with Enterococcus faecalis [ 3 ]. Nevertheless, owing to the contrasting characteristics of different enterococcal strains, these bacteria have emerged as one of the most contentious categories of LAB [ 4 - 6 ]. Consequently, to mitigate potential risks, the focus of research is progressively transitioning from probiotics to inactivated bacterial cells, collectively known as paraprobiotics [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Heat-Killed Enterococcus faecium KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature

Ha,

Lee,

Paik

2024

J. Microbiol. Biotechnol.

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The anti-cancer effects of heat-killed Enterococcus faecium KU22001 (KU22001), KU22002, and KU22005 isolated from human infant feces were investigated. The anti-proliferative activity of these strains against various cancer cell lines was evaluated using the MTT assay. To determine the production of exopolysaccharides (EPS) with potential anti-cancer effect, ethanol precipitation and phenol-sulfuric acid method was used with the cell free supernatant of strains grown at 25°C or 37°C. The EPS yield of E. faecium strains was higher at 25°C than at 37°C. Among these E. faecium strains, KU22001 grown at 25°C was associated with the highest bax / bcl-2 ratio, effective apoptosis rate, cell cycle arrest in the G 0 /G 1 phase, and condensation of the nucleus in the cervical cancer HeLa cell line. In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.

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