Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study

Coates, Paul M.; Vyakrnam, S.; Eady, E. Anne; Jones, C E; Cove, Jonathan H.; Cunliffe, W.J.

doi:10.1046/j.1365-2133.2002.04690.x

Cited by 178 publications

(165 citation statements)

References 21 publications

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“…However, epidemiological studies have shown a marked increase in the frequency of topical antibiotic resistance in acne subjects -from 20% in 1979 to 64% in 2000 -especially resistance to erythromycin and clindamycin. 6,7 As reviewed by Dr eno et al (this issue), C. acnes resistance may be due to several contributing mechanisms, including the formation of biofilm, 8 which can act by restricting penetration of antibiotics. 7 Myrtacine â (Myrtus communis extract) has been demonstrated to be efficient on C. acnes biofilm alone or combined with antibiotics using in vitro models.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Pécastaings

Roques

Nocera

et al. 2018

Acad Dermatol Venereol

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Objective Our main objective was to compare Cutibacterium acnes (C. acnes) skin colonisation in patients with mild to moderate acne versus healthy controls and secondly, to evaluate a Myrtacine â -based cream on C. acnes total population and antibioresistant Cutibacteria in patients with acne.Methods In 60 acne patients (Global Acne Severity Scale, GEA grades 2-3), of mean age 20 [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Results We first showed (i) high and similar levels of C. acnes colonisation in superficial pilosebaceous follicles and detection of EryR and ClnR strains in both acne and control groups; (ii) different repartition of phylotypes in acne patients versus healthy control, with a predominance of phylotype IA in acne patients and a link between phylotype IA and erythromycin resistance. Besides, after treatment with the Myrtacine â -based cream in acne patients, there was no change in C. acnes total load, but a significant decrease of EryR Cutibacteria, reduced porphyrin production by C. acnes, a decrease in acne severity (GEA), associated with reduced retentional and inflammatory lesions.Conclusion Cutibacterium acnes colonisation was not significantly different in acne versus control groups. Phylotype IA was predominant in acne patient and in EryR C. acnes. A Myrtacine â -based cream significantly reduced the level of EryR Cutibacteria in vivo and improved acne lesions.

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Section: Introductionmentioning

confidence: 99%

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Pécastaings

Roques

Nocera

et al. 2018

Acad Dermatol Venereol

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“…Topical and systemic antibiotics, retinoids, and chemical peelings have been used conventionally for acne treatment with variable success rates [4][5][6]. However, a recent increase in the antibiotics resistance of Propionibacterium acnes (P. acnes) and adverse effects of systemic retinoids and antibiotics are becoming obstacles to acne treatment, thus making physicians seek novel treatment modalities [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

2006

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Background and Objectives: Blue light is effective for acne treatment, inducing photodynamic destruction of Propionibacterium acnes (P. acnes). This study was designed to investigate the efficacy of combined blue and red light-emitting diode (LED) phototherapy for acne vulgaris. Materials and Methods: Twenty-four patients with mild to moderately severe facial acne were treated with quasimonochromatic LED devices, alternating blue (415 nm) and red (633 nm) light. The treatment was performed twice a week for 4 weeks. Objective assays of the skin condition were carried out before and after treatment at each treatment session. Clinical assessments were conducted before treatment, after the 2nd, 4th, and 6th treatment sessions and at 2, 4, and 8 weeks after the final treatment by grading and lesion counting. Results: The final mean percentage improvements in noninflammatory and inflammatory lesions were 34.28% and 77.93%, respectively. Instrumental measurements indicated that the melanin levels significantly decreased after treatment. Brightened skin tone and improved skin texture were spontaneously reported by 14 patients. Conclusion: Blue and red light combination LED phototherapy is an effective, safe and non-painful treatment for mild to moderately severe acne vulgaris, particularly for papulopustular acne lesions.

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“…Textbooks still report that they affect the course of acne by causing a decrease in the population of P. acnes and thereby inhibiting bacterial lipases, even though reports of the incidence of resistant strains of P. acnes to clindamycin, tetracycline, erythromycin, and trimethoprimsulfamethoxazole have continued to increase [22,23]. Again, antibiotics do not eliminate P. acnes, but rather control the P. acnes biofilm from producing toxins disadvantageous to the host.…”

Section: Oral Antibiotics In Acnementioning

confidence: 99%

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

Burkhart¹

2008

TODJ

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Patient informational/instructional sheets can be used not only to assist in providing patients with baseline material regarding their condition, but also aid in physicians communicating a treatment protocol. Educational material regarding acne, adult acne, perioral dermatitis, and isotretinoin is included for perusal and discussion. Within this framework, one learns the unifying concept of the Propionibacterium acnes biofilm, methods to maximize production of benzoyl peroxide radicals (the active biological form of this compound), unplugging ability of oral antibiotics, and low-dose isotretinoin therapeutics.

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Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study

Cited by 178 publications

References 21 publications

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

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Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study

Cited by 178 publications

References 21 publications

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

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Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®