Prevalence of antibodies against <i>Treponema pallidum</i> among HIV-positive patients in a tertiary care hospital in Mexico

Mata‐Marín, José Antonio; Sandoval-Sánchez, Juan Joel; Huerta-García, Gloria; Arroyo-Anduiza, Carla Ileana; Alcalá‐Martínez, Enrique; Mata-Marín, Luis Alberto; Sandoval-Ramírez, Jorge Luis; Gaytán-Martı́nez, Jesús

doi:10.1177/0956462414530888

Cited by 9 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This data may be used as feedback to prevent and eradicate HIV/syphilis co-infection in the future. Syphilis seroprevalence in diagnosed HIV infected individuals was reported between 5.2-25% in other countries (16)(17)(18), although social, cultural and economic differences between countries may affect the frequency of STDs. Our study showed the magnitude and quality of HIV/AIDS-syphilis co-infection status for the first time in Turkey and revealed that syphilis co-infection prevalence in HIV/AIDS may be accepted as moderate level.…”

Section: Discussionmentioning

confidence: 99%

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Sarıgül¹,

Sayan

İnan

et al. 2019

Cent Eur J Public Health

View full text Add to dashboard Cite

Objective: Treponema pallidum and HIV are transmitted frequently through sexual contact, these agents with epidemiological similarities coinfect the same host. The current number of HIV-infected cases in Turkey is increasing. For this reason, we aimed to reveal the characteristics of syphilis in HIV/AIDS cases. Methods: A retrospective longitudinal cohort study was performed, patients were followed up at 24 clinics in 16 cities from all seven regions of Turkey between January 2010 to April 2018. We examined the socio-demographic characteristics, laboratory parameters and neurosyphilis association in HIV/AIDS-syphilis co-infected cases. Results: Among 3,641 patients with HIV-1 infection, 291 (8%) patients were diagnosed with syphilis co-infection. Most patients were older than 25 years (92%), 96% were males, 74% were working, 23% unemployed, and 3% were students. The three highest prevalence of syphilis were in Black Sea (10.3%), Mediterranean (8.4%) and Marmara Regions (7.4%). As for sexual orientation, 46% were heterosexuals, 42% men who have sex with men (MSM), and no data available for 12%. Patients with the number of CD4+ ≤ 350 mm 3 reached 46%, 17% of the patients received antiretroviral therapy and neurosyphilis association reached 9%. Conclusion: Although HIV/AIDS-syphilis co-infection status appeared high in heterosexuals, MSM had a moderate level increase in cases. Our results suggested syphilis co-infection in HIV/AIDS cases should be integral part of monitoring in a national sexual transmitted diseases surveillance system. However, our data may provide base for HIV/syphilis prevention and treatment efforts in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Sarıgül¹,

Sayan

İnan

et al. 2019

Cent Eur J Public Health

View full text Add to dashboard Cite

show abstract

“…An estimated 350 000 adverse pregnancy outcomes worldwide occurred as a result of syphilis, including 143 000 early foetal deaths, 62 000 neonatal deaths, 44 000 preterm/low-birth-weight babies and 102 000 infected infants were reported globally [3]. Studies have also shown that Syphilis ulcers can facilitate the transmission of HIV up to 5 times among HIV infected patients [4], [5]. Several methods used for the detection of Syphilis such as microscopy and molecular technologies are currently available.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Molecular Assay for the Detection of Treponema pallidum infection

Shiluli,

Kamath,

Kanoi

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: According to the World Health Organization (WHO) more than 7 million new Treponema pallidum (T. pallidum) infections were reported among people aged 15–49 years in 2020 globally, the majority of them in developing countries. Syphilis, which is caused by T. pallidum is transmitted through contact with active lesions of a sexual partner or from an infected pregnant woman to her foetus. Gold standard T. pallidum laboratory diagnosis methods include dark-field microscopy, silver staining, direct fluorescence immunoassays and the rabbit infectivity test. However, these tests are associated with false positive or negative results. The gold standard 16S ribosomal (rRNA) gene polymerase chain reaction (PCR) is used for routine amplification of T. pallidum conserved genes. Here we report on an ultrasensitive syphilis diagnostic method, based on de novo genome mining of the T. pallidum DNA to identify identical multi repeat sequences (IMRS) as amplification primers. Methods: We used genome-mining approaches to find IMRS distributed throughout the T. pallidum genome to design a primer pair that target four repeat sequences. Genomic T. pallidum DNA was diluted from 8.14×104 to 8.14×10− 2 genome copies/𝜇l and used as template in the IMRS-based amplification assay. For performance comparison, 16S rRNA PCR assay was employed. Probit analysis was used to calculate the lower limit of detection of the T. pallidum-IMRS PCR and the conventional 16S rRNA PCR assays. Results: Probit analysis confirmed that the T. pallidum-IMRS primers offered higher test sensitivity of 0.03 fg/𝜇L compared to the 16S rRNA PCR (0.714 pg/𝜇L). Using the T. pallidum-IMRS primers, we were able to observe considerable isothermal amplification of genomic DNA at a starting concentration of 0.01 pg/µL. Conclusion: De novo genome mining of T. pallidum IMRS as amplification primers can serve as a platform for developing ultrasensitive diagnostics for Syphilis and potentially a wide range of infectious pathogens.

show abstract

“…The HIV epidemic has exacted a severe toll on MSM, with HIV infections from 9.1% in 2009 to 23.3% in 2020 (2). In addition, the prevalence of HIV and syphilis co-infection has increased from 8% (Mexico, 2010(Mexico, -2018 to 25% (Turkey, 2013) (3,4). Previous studies have found that syphilis infections could potentially facilitate HIV transmission and increase the likelihood of acquiring HIV (5).…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, the global rates of substance abuse among men who have sex with men have increased dramatically. Evidence from European countries and China suggests that methamphetamine and ecstasy are the most popular drugs used by MSM in the past years (4)(5)(6). A recent study among 3,588 number of participants that explored drug use problems found that the use of nitrite inhalers have overtaken methamphetamine as the most popular substance abused among MSM (7).…”

Section: Introductionmentioning

confidence: 99%

The epidemic of HIV and syphilis and the correlation with substance abuse among men who have sex with men in China: A systematic review and meta-analysis

Zhao

Chen

Sun

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundIn China, the HIV/AIDS epidemic among men who have sex with men (MSM) has been expanding in recent years. Substance abuse in MSM was not well studied as the independent risk factor for HIV and syphilis infection and other sexually transmitted diseases. The present review aimed to determine the correlation between HIV/Syphilis infections and substance abuse and other sexual risk behaviors among MSM.MethodsWe conducted a comprehensive search of PubMed, Web of Science, Embase, Scopus, Chinese National Knowledge Infrastructure, Chinese Wanfang Data, and VIP Chinese Journal Database for relevant articles of quantitative studies published between 2010 and May 31, 2022. Meta-analysis was performed using R software. Pooled estimated of the association-odds ratio, with 95% confidence intervals were calculated using random-effects models stratified by study design. Q statistics and I2 were used to measure the heterogeneity.ResultsOur meta-analysis included 61,719 Chinese MSM from 52 eligible studies. The pooled HIV prevalence rate among substance-abusing MSM was 10.0% (95% CI = 0.08–0.13). Substance abusers were more likely to have a higher prevalence of HIV (OR = 1.59) and syphilis (OR = 1.48) infections than non-substance abusers. Substance abusers were also more likely to seek sexual partners through the internet or social media applications (OR = 1.63), engage in unprotected anal intercourse (UAI) (OR = 1.69), group sex (OR = 2.78), and engage in commercial intercourse (OR = 2.04) compared to non-users. Regarding testing behaviors, substance abusers had a higher proportion of HIV or STI testing in their lifetime (OR = 1.70) compared with non-substance abusers (p < 0.05). They were also more likely to have had more sexual partners (≥2; OR = 2.31) and more likely to have consumed alcohol (OR = 1.49) in the past 6 months.ConclusionsOur study shows the correlation between substance abuse and HIV/Syphilis infection. Eliminating disparities in HIV/Syphilis infection among substance abusing men who have sex with men (MSM) can be achieved if the Chinese government and public health sectors could provide targeted knowledge popularization and diagnosis interventions among high-risk populations.

show abstract

Prevalence of antibodies against Treponema pallidum among HIV-positive patients in a tertiary care hospital in Mexico

Cited by 9 publications

References 13 publications

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Highly Sensitive Molecular Assay for the Detection of Treponema pallidum infection

The epidemic of HIV and syphilis and the correlation with substance abuse among men who have sex with men in China: A systematic review and meta-analysis

Contact Info

Product

Resources

About