Prevalence of antibodies to peste des petits ruminants virus before and during outbreaks of the disease in Awash Fentale district, Afar, Ethiopia

Delil, Faris; Asfaw, Yilkal; Gebreegziabher, Berhe

doi:10.1007/s11250-012-0110-8

Cited by 27 publications

(23 citation statements)

References 8 publications

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“…Our model, in accordance with these findings, identified the eastern Amhara as at high risk of PPR occurrence (Figure 2). Moreover, high seroprevalence of PPRV in small ruminants was reported in neighboring lowland pastoral areas (11,18,51,52), identified at medium risk by our model. According to our model, highlands are at higher risk for PPR outbreaks than adjacent areas (Figure 2), which seems in apparent contradiction with the cited serosurveys.…”

Section: Discussionmentioning

confidence: 61%

Spatial Multicriteria Evaluation for Mapping the Risk of Occurrence of Peste des Petits Ruminants in Eastern Africa and the Union of the Comoros

et al. 2019

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Peste des petits ruminants virus (PPRV), responsible for peste des petits ruminants (PPR), is widely circulating in Africa and Asia. The disease is a huge burden for the economy and development of the affected countries. In Eastern Africa, the disease is considered endemic. Because of the geographic proximity and existing trade between eastern African countries and the Comoros archipelago, the latter is at risk of introduction and spread, and the first PPR outbreaks occurred in the Union of the Comoros in 2012. The objective of this study was to map the areas suitable for PPR occurrence and spread in the Union of the Comoros and four eastern African countries, namely Ethiopia, Uganda, Kenya, and Tanzania. A Geographic Information System (GIS)-based Multicriteria Evaluation (MCE) was developed. Risk factors for PPR occurrence and spread, and their relative importance, were identified using literature review and expert-based knowledge. Corresponding geographic data were collected, standardized, and combined based on a weighted linear combination to obtain PPR suitability maps. The accuracy of the maps was assessed using outbreak data from the EMPRES database and a ROC curve analysis. Our model showed an excellent ability to distinguish between absence and presence of outbreaks in Eastern Africa (AUC = 0.907; 95% CI [0.820-0.994]), and a very good performance in the Union of the Comoros (AUC = 0.889, 95% CI: [0.694-1]). These results highlight the efficiency of the GIS-MCE method, which can be applied at different geographic scales: continental, national and local. The resulting maps provide decision support tools for implementation of disease surveillance and control measures, thus contributing to the PPR eradication goal of OIE and FAO by 2030.

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Section: Discussionmentioning

confidence: 61%

Spatial Multicriteria Evaluation for Mapping the Risk of Occurrence of Peste des Petits Ruminants in Eastern Africa and the Union of the Comoros

et al. 2019

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“…According to some reports, in mixed populations, the serological prevalence rate has been found to be higher in sheep than in goats, which is attributed by the higher survival rate in sheep [8,194,195]. In contrast, some studies have reported that goats are more susceptible than sheep, and therefore have a higher probability of developing PPRV antibodies [196,197,198]. Interestingly, epidemiological surveillance studies carried out in different enzootic regions have revealed PPRV seroprevalence in other ruminants including cattle, buffalo and camel [194,195].…”

Section: Host Susceptibility and Resistance To Pprmentioning

confidence: 99%

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Kumar

Maherchandani

Kashyap

et al. 2014

Viruses

183

168

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Peste des petits ruminants (PPR) is caused by a Morbillivirus that belongs to the family Paramyxoviridae. PPR is an acute, highly contagious and fatal disease primarily affecting goats and sheep, whereas cattle undergo sub-clinical infection. With morbidity and mortality rates that can be as high as 90%, PPR is classified as an OIE (Office International des Epizooties)-listed disease. Considering the importance of sheep and goats in the livelihood of the poor and marginal farmers in Africa and South Asia, PPR is an important concern for food security and poverty alleviation. PPR virus (PPRV) and rinderpest virus (RPV) are closely related Morbilliviruses. Rinderpest has been globally eradicated by mass vaccination. Though a live attenuated vaccine is available against PPR for immunoprophylaxis, due to its instability in subtropical climate (thermo-sensitivity), unavailability of required doses and insufficient coverage (herd immunity), the disease control program has not been a great success. Further, emerging evidence of poor cross neutralization between vaccine strain and PPRV strains currently circulating in the field has raised concerns about the protective efficacy of the existing PPR vaccines. This review summarizes the recent advancement in PPRV replication, its pathogenesis, immune response to vaccine and disease control. Attempts have also been made to highlight the current trends in understanding the host susceptibility and resistance to PPR.

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“…Goats have been found to be more susceptible with severe form of clinical disease than sheep (Lefevre and Diallo, 1990; Nanda et al, 1996; Dhar et al, 2002; Singh et al, 2004a; Delil et al, 2012; Truong et al, 2014). It has also been observed that the rate of recovery is lower in goats than in sheep (Singh et al, 2004a).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Host miRNAs Transcriptome in Lung and Spleen of Peste des Petits Ruminants Virus Infected Sheep and Goats

et al. 2017

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Peste des petits ruminants (PPR) is one of the highly contagious viral disease, characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, primarily affecting sheep and goats. Reports suggested variable host response in goats and sheep and this host response vis-a-vis the expression of microRNAs (miRNAs) has not been investigated. Here, miRNAs were sequenced and proteomics data were generated to identify the role of differentially expressed miRNA (DEmiRNA) in PPR virus (PPRV) infected lung and spleen tissues of sheep and goats. In lungs, 67 and 37 DEmiRNAs have been identified in goats and sheep, respectively. Similarly, in spleen, 50 and 56 DEmiRNAs were identified in goats and sheep, respectively. A total of 20 and 11 miRNAs were found to be common differentially expressed in both the species in PPRV infected spleen and lung, respectively. Six DEmiRNAs—miR-21-3p, miR-1246, miR-27a-5p, miR-760-3p, miR-320a, and miR-363 were selected based on their role in viral infections, apoptosis, and fold change. The target prediction analysis of these six selected DEmiRNAs from the proteome data generated, revealed involvement of more number of genes in lung and spleen of goats than in sheep. On gene ontology analysis of host target genes these DEmiRNAs were found to regulate several immune response signaling pathways. It was observed that the pathways viz. T cell receptor signaling, Rap1 signaling, Toll-like receptor signaling, and B cell receptor signaling governed by DEmiRNAs were more perturbed in goats than in sheep. The data suggests that PPRV-induced miR-21-3p, miR-320a, and miR-363 might act cooperatively to enhance viral pathogenesis in the lung and spleen of sheep by downregulating several immune response genes. The study gives an important insight into the molecular pathogenesis of PPR by identifying that the PPRV—Izatnagar/94 isolate elicits a strong host response in goats than in sheep.

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Prevalence of antibodies to peste des petits ruminants virus before and during outbreaks of the disease in Awash Fentale district, Afar, Ethiopia

Cited by 27 publications

References 8 publications

Spatial Multicriteria Evaluation for Mapping the Risk of Occurrence of Peste des Petits Ruminants in Eastern Africa and the Union of the Comoros

Spatial Multicriteria Evaluation for Mapping the Risk of Occurrence of Peste des Petits Ruminants in Eastern Africa and the Union of the Comoros

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Modulation of Host miRNAs Transcriptome in Lung and Spleen of Peste des Petits Ruminants Virus Infected Sheep and Goats

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