Prevalence of antidepressant-induced sexual dysfunction among psychiatric outpatients attending a tertiary care hospital

Abstract

‫العيادات‬ ‫مرضى‬ ‫في‬ ‫اجلنسي‬ ‫الوظيفي‬ ‫اخللل‬ ‫انتشار‬ ‫لقياس‬ ‫األهداف:‬ ‫الباروكستني‬ ‫أو‬ ‫بالفلوكستني‬ ‫عوجلوا‬ ‫الذين‬ ‫النفسية‬ ‫لألمراض‬ ‫اخلارجية‬ ‫امليرتازابني.‬ ‫أو‬ ‫الفينالفاكسني‬ ‫أو‬ ‫جامعة‬ ‫مستشفى‬ ‫في‬ ‫رجعي‬ ‫بأثر‬ ‫مقطعية‬ ‫دراسة‬ ‫أجريت‬ ‫املنهجية:‬ ‫سن‬ ‫فوق‬ ‫املرضى‬ ‫جميع‬ ‫دعينا‬ ‫عمان.‬ ، ‫مسقط‬ ‫قابوس،‬ ‫السلطان‬ ‫النفسية‬ ‫العيادة‬ ‫حضروا‬ ‫الذين‬ ‫الدراسة،‬ ‫في‬ ‫للمشاركة‬ ‫عام‬ 18 ‫أو‬ ‫فينالفاكسني‬ ، ‫باروكستني‬ ‫فلوكستني،‬ ‫من‬ ‫كال‬ ‫واستخدموا‬ ‫لتوثيق‬ ‫البيانات‬ ‫جلمع‬ ‫ورقة‬ ‫تصميم‬ ‫مت‬ ‫املؤشرات.‬ ‫ملختلف‬ ‫ميرتازابني‬ ‫وجرعة‬ ‫ونوع‬ ‫النفسي‬ ‫والتشخيص‬ ‫للمرضى‬ ‫الدميوغرافية‬ ‫اخلصائص‬ ‫اجلانبية‬ ‫اآلثار‬ ‫من‬ ‫جزء‬ ‫استخدام‬ ‫مت‬ ‫لالكتئاب.‬ ‫املضاد‬ ‫العالج‬ ‫ومدة‬ ‫وظيفي‬ ‫خلل‬ ‫وجود‬ ‫لتقييم‬ TSES‫لـ‬ ‫اجلانبي‬ ‫التأثير‬ ‫مقياس‬ ‫من‬ ‫اجلنسية‬ ‫جنسي.‬ ‫أنثى:‬ ،51% ‫(ذكر:‬ ‫مريضا‬ 137 ‫على‬ ‫الدراسة‬ ‫اشتملت‬ ‫النتائج:‬ ‫(املدى:‬ ‫ا‬ ً ‫عام‬ 38 ‫للمشاركني‬ ‫العمر‬ ‫متوسط‬ ‫كان‬ ‫الدراسة.‬ ‫في‬ )49% ‫على‬ ‫االكتئاب‬ ‫مضادات‬ ‫لكل‬ ‫املرضى‬ ‫عدد‬ ‫وكان‬ ‫ا).‬ ً ‫عام‬ 19-72 ، ‫ا)‬ ‫مريضً‬ 36( ‫فلوكستني‬ ، ‫ا)‬ ‫مريضً‬ 52( ‫باروكستني‬ ‫التالي:‬ ‫النحو‬ ‫متوسط‬ ‫وكان‬ ‫ا).‬ ‫مريضً‬ 17( ‫وفينالفاكسني‬ ‫ا)‬ ‫مريضً‬ 36( ‫ميرتازابني‬ ‫انتشار‬ ‫معدل‬ ‫كان‬ ‫سنوات.‬ 17 ‫االكتئاب‬ ‫مضادات‬ ‫استخدام‬ ‫مدة‬ ‫االكتئاب‬ ‫مضادات‬ ‫أكثر‬ ‫هو‬ ‫الباروكستني‬ ‫كان‬ .39% ‫اجلنسي‬ ‫العجز‬ ‫انخفاض‬ ‫بسبب‬ ً ‫خاصة‬ ‫اجلنسي‬ ‫الوظيفي‬ ‫باالختالل‬ ‫املرتبطة‬ ‫ا‬ ً ‫شيوع‬ ‫املقابل،‬ ‫في‬ .)34.4%( ‫القذف‬ ‫وتأخر‬ )59.6%( ‫اجلنسية‬ ‫الرغبة‬ ‫اختالل‬ ‫تسبب‬ ‫التي‬ ‫االكتئاب‬ ‫مضادات‬ ‫بني‬ ‫األقل‬ ‫هو‬ ‫امليرتازابني‬ ‫كان‬ ‫جنسي.‬ ‫وظيفي‬ ‫مبضادات‬ ‫عوجلوا‬ ‫الذين‬ ‫املرضى‬ ‫بني‬ ‫شائع‬ ‫اجلنسي‬ ‫اخللل‬ ‫إن‬ ‫اخلالصة:‬ ‫االنتقائية‬ ‫السيروتونني‬ ‫امتصاص‬ ‫مثبطات‬ ‫وخاصة‬ ‫االكتئاب‬ ‫في‬ ‫املبكرة‬ ‫اجلانبية‬ ‫اآلثار‬ ‫هذه‬ ‫معاجلة‬ ‫تؤدي‬ ‫أن‬ ‫ميكن‬ .)SSRIs( ‫االنتكاسات‬ ‫ومنع‬ ‫للعالج‬ ‫االمتثال‬ ‫حتسني‬ ‫إلى‬ ‫العالج‬ Objectives:To measure the prevalence of sexual dysfunction in psychiatric outpatients treated with fluoxetine, paroxetine, venlafaxine or mirtazapine.Methods: This is a retrospective cross-sectional study conducted in Sultan Qaboos University Hospital, Original ArticlesMuscat, Oman. All patients above 18 years of age, attending psychiatric clinic and taking fluoxetine, paroxetiene, venlafaxine or mirtazapine for various indications were invited to participate in the study. A data collection sheet was designed to document the patients' demographic features, psychiatric diagnosis, type, dose and duration of antidepressant treatment. Sexual side effects' part of Toronto Side Effect Scale )TSES( was used to assess the presence of sexual dysfunction.Results: A total of 137 patients )Male: 51%, Female: 49%( were included in the study. The mean age for the participants was 38 years )range: 19-72 years(.The number of patients for each antidepressant was as follows: paroxetine )52 patients(, fluoxetine )36(, mirtazapine )36 patients( and venlafaxine )17 patients(. The average duration of the antidepressant use was 3.9 years. The overall prevalence of sexual dysfunction was 39%. Paroxetine was...

Level of selective serotonin reuptake inhibitor-related sexual dysfunction in men and women

“…The activation of the postsynaptic serotonin (5-HT) 2A receptor is suggested to be a significant contributor to antidepressant-related sexual dysfunction (4). Paroxetine showed a higher risk for sexual dysfunction compared with other SSRIs (5,8,9).…”

“…Many people experience a kind of sexual dysfunction related to antidepressants (5). SSRI-induced sexual dysfunction may be up to 80% (2).…”

Prevalence of antidepressant-induced sexual dysfunction among psychiatric outpatients attending a tertiary care hospital

“…To the Editor I have read with interest the original article entitled "Prevalence of antidepressant-induced sexual dysfunction among psychiatric outpatients attending a tertiary care hospital" by Mohammed AlBreiki et al, published in Neurosciences journal. 1 I want to commend the authors for selecting an interesting topic with a wide range of age, absence of organic diseases that causes sexual dysfunction, and the patients used 4 different antidepressant compounds. There are certain methodological concerns which might create a response bias among patients suffering from sexual dysfunction.…”

A Systematic Review on the Effect of Nutraceuticals on Antidepressant-Induced Sexual Dysfunctions: From Basic Principles to Clinical Applications

“…According to previous studies, SDs are reported by 25% up to 75% of patients taking SSRIs and by 30% up to 93% of those taking TCAs [ 1 , 3 ]. SDs may engage the phase of the sex drive (loss of libido), the arousal (lubrication in women, erectile function in men), the ejaculation, and orgasm [ 4 ]. Data collected in recent decades confirm that there are significant differences in antidepressant-induced SD (AISD) between men and women.…”