Prevalence of antileptospiral serum antibodies in dogs in Ireland

Schüller, Simone; Arent, Zbigniew; Gilmore, C.; Nally, Jarlath E.

doi:10.1136/vr.102916

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…In dogs the disease shows at least three different pathologic syndromes: icteric syndrome, uremic syndrome and hemorrhagic syndrome (Adler and de la Peña-Moctezuma, 2010). Seroprevalence in cattle may be as high as 84% and in dogs 35% (de Freitas et al, 2010, Ellis et al, 1986b, Oliveira Lavinsky et al, 2012, Schuller et al, 2015. Lower incidences have been found in other domestic animals among them sheep acting mainly as asymptomatic reservoirs (Cerri et al, 1996, Ellis et al, 1994, Lilenbaum et al, 2009; in horses the disease usually has a chronic course resulting in recurrent uveitis (ERU) being the main cause of equine blindness (Halliwell et al, 1985, Malalana et al, 2015, Wollanke et al, 2001.…”

Section: Human Animal and Environmental Reservoirsmentioning

confidence: 99%

Leptospira and Leptospirosis

Goarant¹,

Trueba²,

Bierque³

et al. 2019

Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Wate

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The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The ideas and opinions expressed in this publication are those of the authors; they are not necessarily those of UNESCO and do not commit the Organization.

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Section: Human Animal and Environmental Reservoirsmentioning

confidence: 99%

Leptospira and Leptospirosis

Goarant¹,

Trueba²,

Bierque³

et al. 2019

Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Wate

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“…Leptospirosis in dogs has been associated with serovars Canicola and Icterohaemorraghiae but it is now clear that dogs are susceptible to infection with multiple serovars (Schuller et al., 2015a). In Europe, Grippotyphosa and Bratislava have emerged as major causes of canine leptospirosis (Ellis, 2010; Mayer-Scholl et al., 2013; Renaud et al.…”

Section: Introductionmentioning

confidence: 99%

“…from dogs to humans. Dogs could serve as an important sentinel specie for human infection, as well as indicator of the presence of leptospires in specific environments (Ghneim et al., 2007; Major et al., 2014; Schuller et al., 2015a).…”

Section: Introductionmentioning

confidence: 99%

Leptospira seroprevalence in owned dogs from Spain

López

Vilà

Rodón³

et al. 2019

Heliyon

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Leptospira is a widespread zoonosis that has been linked to transmission between dogs and humans. The main purposes were to determine the seroprevalence of anti- Leptospira serum antibody and to identify the most common serovars in dogs in Spain. This is a cross-sectional study with 1,310 records of canine Leptospira testing data from Spain since 2015 to 2017. Inclusion criteria were individual cases with MAT test results for 8 serovars (Bratislava, Icterohaemorrhagiae, Australis, Pomona, Grippotyphosa, Autumnalis, Canicola and Saxkoebing) and to have the zip code data. Three hundred and thirty-eight samples (25.8%; 95%CI 23.6–28.4) were seropositive (≥1:100). According to geographic areas, North had the highest seroprevalence (38.0%; 95%CI 28.9–47.1) followed by South (29.4%; 95%CI 20.1–38.8), Center (28.6%; 95%CI 24.3–33.0), Mediterranean (22.3%; 95%CI 19.1–25.6) and Northwest (22.2%; 95%CI 7.9–36.4). Seropositivity (MAT ≥1:100) was most common to serovars Icterohaemorrhagiae (19.4%; 95%CI 17.2–21.5) and Bratislava (8.5%; 95%CI 7.0–10.0), followed by Grippotyphosa (7.2%; 95%CI 5.8–8.6), Australis (6.4%; 95%CI 5.0–7.7), Autumnalis (5.0%; 95%CI 3.8–6.2), Pomona (4.5%; 95%CI 3.3–5.6), Canicola (3.4%; 95%CI 2.4–4.4) and Saxkoebing (0.8%; 95%CI 0.3–1.3). An association was found between positivity (MAT ≥1:100) and males (P = 0.003) and dogs that were 6 years old or older were at higher risk of exposure (P = 0.001; OR 4.61; 95%CI 1.86–11.43). This study has shown that dogs in Spain are commonly exposed to Leptospira infection and points out the necessity to control the prevalence of this severe widespread zoonosis in dogs and humans.

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“…Although the inclusion of serogroup Icterohaemorrhagiae in vaccine formulations has led to its decreasing seroprevalence in Italy [ 46 ], this serogroup is still a major cause of disease in dogs, owing to the ubiquitous nature of its maintenance host. The dog, in this case, represents a spill-over and can be used as an important sentinel species for human and other animal infections [ 51 , 52 , 53 ]. Interestingly, the IZSLER database revealed that Leptospira ST17 occurs in different hosts (mouse, cat, hedgehog, horse, goat and cow), which indicates its ability to cause infection in a wide range of animal species.…”

Section: Discussionmentioning

confidence: 99%

Detection of New Leptospira Genotypes Infecting Symptomatic Dogs: Is a New Vaccine Formulation Needed?

et al. 2020

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Leptospirosis in dogs has been largely described worldwide, and epidemiological studies have been mainly based on serological data. This study aims to detect and genotype leptospires affecting symptomatic dogs in Northeast Italy between 2013 and 2019. Overall, 1631 dogs were tested using real-time PCR, and leptospires from 193 dogs were subjected to Multilocus Sequence Typing and a Multiple Loci Variable-number Tandem Repeat Analysis. Leptospires were successfully isolated from 15 symptomatic dogs. Six distinct Sequence Types (STs) were found for 135 leptospires, with 3 STs characterizing Leptospira interrogans (ST17, ST198 and ST24), 2 STs characterizing Leptospira kirschneri (ST117 and ST289) and 1 ST characterizing Leptospira borgpetersenii (ST155), revealing the circulation of the serogroups Icterohaemorrhagiae, Australis, Sejroe and Pomona. The Multiple Loci Variable-number Tandem Repeat Analysis of 17 samples did not result in any additional discrimination. Genotypes were compared with those of strains present in the historical internal database, and possible transmission chains were identified from rat, mouse, hedgehog and pig. This work highlights the importance of molecular methods in revealing and identifying circulating Leptospira strains, and it also encourages the evaluation of the ability of commercially available vaccines to reduce the disease burden among dogs.

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Prevalence of antileptospiral serum antibodies in dogs in Ireland

Cited by 13 publications

References 24 publications

Leptospira and Leptospirosis

Leptospira and Leptospirosis

Leptospira seroprevalence in owned dogs from Spain

Detection of New Leptospira Genotypes Infecting Symptomatic Dogs: Is a New Vaccine Formulation Needed?

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