Prevalence of antiseptic-resistance genes in  Staphylococci  isolated from orthokeratology lens and spectacle wearers in Hong Kong

Shi, Guang Sen; Boost, Maureen; Cho, Pauline

doi:10.1016/j.clae.2018.04.179

Cited by 3 publications

(3 citation statements)

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“…Micro‐organisms carrying such determinants are more resistant to therapy and may not be eliminated from the lens during the disinfection process. A study comparing spectacle wearers with long‐term ortho‐K lens users revealed that the latter group had significantly more isolates positive for antiseptic resistance genes . This was confirmed to be associated with contact lens wear by a longitudinal study in which subjects were sampled before and at two subsequent visits after commencement of lens wear.…”

Section: Use Of Contact Lensesmentioning

confidence: 88%

Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome

Boost

Cho

Wang

2017

Clinical and Experimental Optometry

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Contact lens wear is a popular, convenient and effective method for vision correction. In recent years, contact lens practice has expanded to include new paradigms, including orthokeratology; however, their use is not entirely without risk, as the incidence of infection has consistently been reported to be higher in contact lens wearers. The explanations for this increased susceptibility have largely focused on physical damage, especially to the cornea, due to a combination of hypoxia, mechanical trauma, deposits and solution cytotoxicity, as well as poor compliance with care routines leading to introduction of pathogens into the ocular environment. However, in recent years, with the increasing availability and reduced cost of molecular techniques, the ocular environment has received greater attention with in‐depth studies of proteins and other components. Numerous proteins were found to be present in the tears and their functions and interactions indicate that the tears are far more complex than formerly presumed. In addition, the concept of a sterile or limited microbial population on the ocular surface has been challenged by analysis of the microbiome. Ocular microbiome was not considered as one of the key sites for the Human Microbiome Project, as it was thought to be limited compared to other body sites. This was proven to be fallacious, as a wide variety of micro‐organisms were identified in the analyses of human tears. Thus, the ocular environment is now recognised to be more complicated and interference with this ecological balance may lead to adverse effects. The use of contact lenses clearly changes the situation at the ocular surface, which may result in consequences which disturb the balance in the healthy eye.

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Section: Use Of Contact Lensesmentioning

confidence: 88%

Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome

Boost

Cho

Wang

2017

Clinical and Experimental Optometry

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“…Most rigid corneal lens MPS contain quaternary ammonium compounds, which are effective against a wide range of common ocular pathogens [175], but long-term use of such MPS may lead to selection of organisms harbouring quaternary ammonium compound genes [198]. For example, resistance to the concentration of quaternary ammonium compound disinfectant in rigid lens solutions has been observed in staphylocci [199].…”

Section: Disinfectants and Resistant-microorganismsmentioning

confidence: 99%

BCLA CLEAR - Orthokeratology

Vincent

Cho

Chan³

et al. 2021

Contact Lens and Anterior Eye

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115

103

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Orthokeratology (ortho-k) is the process of deliberately reshaping the anterior cornea by utilising specialty contact lenses to temporarily and reversibly reduce refractive error after lens removal. Modern ortho-k utilises reverse geometry lens designs, made with highly oxygen permeable rigid materials, worn overnight to reshape the anterior cornea and provide temporary correction of refractive error. More recently, ortho-k has been extensively used to slow the progression of myopia in children.This report reviews the practice of ortho-k, including its history, mechanisms of refractive and ocular changes, current use in the correction of myopia, astigmatism, hyperopia, and presbyopia, and standard of care. Suitable candidates for ortho-k are described, along with the fitting process, factors impacting success, and the potential options for using newer lens designs. Ocular changes associated with ortho-k, such as alterations in corneal thickness, development of microcysts, pigmented arcs, and fibrillary lines are reviewed. The safety of ortho-k is extensively reviewed, along with an overview of non-compliant behaviours and appropriate disinfection regimens. Finally, the role of ortho-k in myopia management for children is discussed in terms of efficacy, safety, and potential mechanisms of myopia control, including the impact of factors such as initial fitting age, baseline refractive error, the role of peripheral defocus, higher order aberrations, pupil size, and treatment zone size.

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“…Thus, the product of qacC/smr on the bacterial membrane could result in the efflux of BAC from the bacterial cytoplasm. 14 Shi et al 15 reported that staphylococci with qac genes could be found on the ocular surface with longterm orthokeratology lens use. Because contact lens solutions generally contain some disinfectants, orthokeratology lens users are likely constantly exposed to BAC/QAC.…”

Section: Discussionmentioning

confidence: 99%

Benzalkonium Chloride Resistance in Staphylococcus epidermidis on the Ocular Surface of Glaucoma Patients Under Long-Term Administration of Eye Drops

Lee

Iwasaki

Ohtani

et al. 2020

Trans. Vis. Sci. Tech.

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Prevalence of antiseptic-resistance genes in Staphylococci isolated from orthokeratology lens and spectacle wearers in Hong Kong

Cited by 3 publications

References 0 publications

Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome

Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome

BCLA CLEAR - Orthokeratology

Benzalkonium Chloride Resistance in Staphylococcus epidermidis on the Ocular Surface of Glaucoma Patients Under Long-Term Administration of Eye Drops

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