Prevalence of any size adenomas and advanced adenomas in 40- to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carcinoma in a first-degree relative

Gupta, Akshay; Samadder, Jewel; Elliott, Eric E.; Sethi, Saurabh; Schoenfeld, Philip

doi:10.1016/j.gie.2011.02.010

Cited by 25 publications

(23 citation statements)

References 14 publications

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“…7 Stratified analysis of previous data by age showed that advanced neoplasia in young patients mostly occurs in patients aged 40 to 49 years. 7,32,[38][39][40][41][42] Our results call into question the ASGE guidelines, which recommend colonoscopy for patients aged O50 years with hematochezia but not for younger patients if a benign alternative source of bleeding is present. 8 Similarly, French guidelines do not favor colonoscopy for patients aged !50 years with rectal bleeding unless the bleeding is chronic or recurrent.…”

Section: Discussionmentioning

confidence: 73%

Findings of diagnostic colonoscopy in young adults versus findings of screening colonoscopy in patients aged 50 to 54 years: a comparative study stratified by symptom category

Cha

Kozarek

Selva

et al. 2015

Gastrointestinal Endoscopy

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Section: Discussionmentioning

confidence: 73%

Findings of diagnostic colonoscopy in young adults versus findings of screening colonoscopy in patients aged 50 to 54 years: a comparative study stratified by symptom category

Cha

Kozarek

Selva

et al. 2015

Gastrointestinal Endoscopy

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“…CRC is considered the third cause of cancerrelated death in the world (Gupta et al, 2011;Siegel et al, 2012;Baghestani et al, 2014). Following breast cancer, it is the second most common cancer among women and is also the third most common cancer among men (Ansari et al, 2006;Ferlay et al, 2010;Siegel et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the prime causes of mortality around the globe, with a significantly rising incidence in the Middle East region in recent decades. Since detection of CRC in the early stages is an important issue, and also since to date there are no comprehensive epidemiologic studies depicting the Middle East region with special attention to the average risk group, further investigation is of significant necessity in this regard. Aim: Our aim was to investigate the prevalence of preneoplastic and neoplastic lesions of the colon in an average risk population. Materials and Methods: A total of 1,208 eligible asymptomatic, average-risk adults older than 40 years of age, referred to Firuzgar Hospotal in the years 2008-2012, were enrolled. They underwent colonoscopy screening and all polypoid lesions were removed and examined by an expert gastrointestinal pathologist. The lesions were classified by size, location, numbers and pathologic findings. Size of lesions was measured objectively by endoscopists. Results: The mean age of participants was 56.5 ± 9.59 and 51.6% were male. The overall polyp detection rate was 199/1208 (16.5 %), 26 subjects having non-neoplastic polyps, including hyperplastic lesions, and 173/1208 (14.3%) having neoplastic polyps, of which 26 (2.15%) were advanced neoplasms .The prevalence of colorectal neoplasia was more common among the 50-59 age group. Advanced adenoma was more frequent among the 60-69 age group. The majority of adenomas were detected in the distal colon, but a quarter of advanced adenomas were found in the proximal colon; advance age and male gender was associated with the presence of adenoma. Conclusions: It seems that CRC screening among average-risk population might be recommended in countries such as Iran. However, sigmioidoscopy alone would miss many colorectal adenomas. Furthermore, the 50-59 age group could be considered as an appropriate target population for this purpose in Iran.

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“…Screening in familial colorectal cancer An increased rate of colonic adenoma detection is also reported in individuals with a family history of CRC in comparison with average-risk subjects [20][21][22][23][24][25][26] . Colorectal adenoma > 10 mm, with high-grade dysplasia and/or a villous component, termed as advanced adenoma (ADA), is a precursor of CRC.…”

Section: Introductionmentioning

confidence: 99%

“…Colorectal adenoma > 10 mm, with high-grade dysplasia and/or a villous component, termed as advanced adenoma (ADA), is a precursor of CRC. Several colonoscopy-based screening studies [21][22][23][24][25] reported an increased prevalence of ADA in FDRs of CRC patients, ranging from 3.3% to 21.3%, in relation to average-risk subjects in whom it was defined as 1.9%-11.5%. A high prevalence of ADA has also been described among young FDRs aged 40-45 years, which increased with age [25] .…”

Section: Introductionmentioning

confidence: 99%

Familial colorectal cancer screening: When and what to do?

Blanco¹,

Paoluzi²,

Sileri³

et al. 2015

WJG

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Colorectal cancer (CRC) is the third leading cause of death worldwide and represents a clinical challenge. Family members of patients affected by CRC have an increased risk of CRC development. In these individuals, screening is strongly recommended and should be started earlier than in the population with average risk, in order to detect neoplastic precursors, such as adenoma, advanced adenoma, and nonpolypoid adenomatous lesions of the colon. Fecal occult blood test (FOBT) is a non invasive, widespread screening method that can reduce CRC-related mortality. Sigmoidoscopy, alone or in addition to FOBT, represents another screening strategy that reduces CRC mortality. Colonoscopy is the best choice for screening highrisk populations, as it allows simultaneous detection and removal of preneoplastic lesions. The choice of test depends on local health policy and varies among countries. Core tip: One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) affected by this malignancy. Screening is an efficient method to reduce mortality for CRC and should be started in FDRs earlier than in the population at average risk. There is a large disparity in guidelines for screening in familial CRC, therefore, here we address the principal indication and methods for screening in this population at increased risk. Recent or emerging methods to improve the participation rate in screening programs are described. Ongoing trials on CRC screening are also reported.

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Prevalence of any size adenomas and advanced adenomas in 40- to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carcinoma in a first-degree relative

Cited by 25 publications

References 14 publications

Findings of diagnostic colonoscopy in young adults versus findings of screening colonoscopy in patients aged 50 to 54 years: a comparative study stratified by symptom category

Findings of diagnostic colonoscopy in young adults versus findings of screening colonoscopy in patients aged 50 to 54 years: a comparative study stratified by symptom category

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Familial colorectal cancer screening: When and what to do?

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