Prevalence of Apical Periodontitis in Patients with Inflammatory Bowel Diseases: A Retrospective Clinical Study

High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study

“…Crohn's disease patients required significantly more endodontic treatments when compared with controls. 35 Recently, Piras et al (2017) 15 have reported that the number of teeth with AP in women with IBD are significantly higher. Patients with IBD showed a significantly higher PAI index score than controls.…”

“…The system for the selection of patients was similar to that used in previously published studies. 10,11,15 It is possible that IBD patients had more concerns about their overall dental health and were more likely to participate in the study. This could result in a spurious association between IBD and periapical disease.…”

“…This has also happened recently with IBD. 15,29 Even though the etiology of IBD is not exactly known, it has been shown that both genetic and environmental factors play a role in its pathogenesis. 30 The characteristic intestinal inflammation would be produced by an inadequate immune response of the intestinal mucosa against the luminal antigens in a host with genetic susceptibility, resulting in an imbalance of pro-inflammatory and anti-inflammatory factors.…”

“…13,14 Moreover, a previous study showed that women with IBD had a greater prevalence of AP, and subjects with IBD had larger periapical lesions than healthy subjects. 15 However, the available scientific evidence is inconsistent. The aim of this age-and gender-matched casecontrol study was to analyze the prevalence of apical periodontitis, assessed as radiolucent periapical lesions (RPLs) and the frequency of root filled teeth (RFT) in healthy control patients and patients with IBD.…”

JAK2‐STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis

“…However, in some cases, root canal therapy does not fully clear the infection. This is especially the case in patients with periapical periodontitis and inflammatory bowel diseases, as the area of periapical bone resorption is significantly increased in these patients (Piras et al, ), possibly due to antigens in the root canal and the immune response of apical tissue (Estrela et al, ). Enterococcus faecalis is a common pathogen in secondary and refractory pulp periapical periodontitis (Chávez de Paz, Davies, Bergenholtz, & Svensäter, ; Wang et al, ), and its virulence factor—lipoteichoic acid (LTA)—has strong immunogenicity.…”