Prevalence of arterial hypertension in cirrhosis of liver

Prabhu, P Rajesh; Ramalingam, Srinivasan; Jayanthi, V.

doi:10.4103/1319-3767.45067

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…In the current study, the prevalence of arterial hypertension in patients with liver cirrhosis was 30.8%. In contrast to our result, Prabhu et al,2009 reported that the prevalence of arterial hypertension in patients with liver cirrhosis was 7%, which is less than that among the Indian general population (10-15%) ] 7[. This may be explained by that the prevalence of hypertension in Egyptian adult population in that age group (45-59ys) is 50.6% [6] which is higher than Indian population.…”

Section: Discussioncontrasting

confidence: 99%

“…The majority of hypertensive patients in our study were Child-Pugh class A (72.9%) and patients in Child-Pugh class B and C were significantly decreased in hypertensive group than those without hypertension (P <0.001) which could explain that, the biochemical laboratory investigations are better in hypertensive patients when compared with non-hypertensives (P <0.05). These results are in consistent with Henriksen &Moller,2006 andPrabhu, et al,2009 who found majority of hypertensive patients in their studies were Child A [7,13[. In addition to Gomez, et al, 2014 who found the frequency of arterial hypertension in cirrhotic patients is substantially reduced in advanced cirrhosis.…”

Section: Many Studies Shown a Relation Between Hcv Infection And Arte...supporting

confidence: 87%

“…The prevalence of arterial hypertension in our patients with liver cirrhosis was still lower than general population. This goes with Henriksen &Moller, 2006 andPrabhu, et al,2009 studies which reported the relatively low prevalence of hypertension among the patients with cirrhosis] 7,13[. Thereby postulating the possible protective effects of cirrhosis on the cardiovascular system, patients with cirrhosis exhibit profound and progressive derangements in systemic and regional hemodynamics.…”

Section: Discussionmentioning

confidence: 56%

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Prevalence of arterial hypertension in liver cirrhosis and correlation with the severity of liver disease

Gazzar

Ali

Yousef

et al. 2022

ijhs

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Background and aim: Metabolic diseases and hypertension have increased dramatically in recent years, so the prevalence of hypertension in patients with cirrhosis is expected to increase. The aim of the study was to estimate the prevalence of hypertension in patients with liver cirrhosis and to determine its association with the severity of the liver disease. Patients and methods: This was a descriptive, cross-sectional, analytical study conducted at the Tropical Medicine and Infectious Diseases Department, Tanta University Hospital, Egypt. A total of 2051 patients with liver cirrhosis of various etiology were screened for participation in this study. 2014 patients were enrolled. They underwent blood pressure evaluation, blood tests and abdominal ultrasonography. Patients were classified into hypertensive and non-hypertensive groups. Results: The prevalence of arterial hypertension in patients with liver cirrhosis was 30.8%. As regards Child-Pugh class, hypertensive patients in class A were significantly increased (72.9 versus 48.7% respectively) while patients in class B and C were significantly decreased when compared with non- hypertensive patients (25.5,1.6 versus 33.29,17.93% respectively) (P <0.001). Conclusions: The prevalence of arterial hypertension in Egyptian cirrhotic patients is 30.7%, lower than that of the general population. Arterial hypertension is inversely associated with the severity of liver disease.

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Section: Discussioncontrasting

confidence: 99%

Section: Many Studies Shown a Relation Between Hcv Infection And Arte...supporting

confidence: 87%

Section: Discussionmentioning

confidence: 56%

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Prevalence of arterial hypertension in liver cirrhosis and correlation with the severity of liver disease

Gazzar

Ali

Yousef

et al. 2022

ijhs

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“…The evaluation of SAH remains controversial in patients with advanced liver abnormalities; the prevalence of manifestation in this group is low, even in cases of renovascular disease and high circulating renin activity; patients with established arterial hypertension may become normotensive during the progression of liver disease. Future studies focus on assessing the propensity for vasodilator changes, such as hepatopulmonary syndrome, to verify the risk of this complication in patients with advanced liver disorders (Henriksen and Møller, 2004;Henriksen et al, 2006;Rajesh et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

NGF (−198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

Pereira

Amoras

Conde

et al. 2020

Mol Med

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Backgrounds: Neural growth factor (NGF) is a neurotrophin that can interact with the p75 NTR receptor and initiate a cascade of reactions that determines cell survival or death, and both are associated with the physiology of liver tissue. Single nucleotide polymorphisms (SNPs) in the NGF and p75 NTR genes have been investigated in different pathologies; however, there are no studies that have analyzed their biological roles in the hepatic microenvironment. In the present study, we evaluated the impact of SNPs in these genes on the maintenance of liver function at different stages of inflammation and fibrosis in patients with chronic viral liver disease in the Brazilian Amazon. Methods: The SNPs-198C > T, Arg80Gln, Val72Met, Ala35Val, Ala18Ala and Ser205Leu were genotyped by real-time PCR in samples from patients with chronic viral hepatitis stratified by stage of inflammation and liver fibrosis. Histopathological, viral load (VL), liver enzyme and comorbidities data were obtained from updated medical records. Other aspects were highlighted by applied epidemiological questionnaires. Results: The-198C/T and Ala35Val polymorphisms in NGF were associated with changes in histopathological profiles, VL and liver enzymes. Ser205Leu polymorphism in p75 NTR was associated only with changes in VL and liver enzymes. Polymorphic frequencies were variable among different ethnic populations, mainly for biologically relevant polymorphisms. A multifactorial network of interactions has been established based on genetic, virological, behavioral and biochemical aspects. Conclusion: Mutations in the NGF (−198C > T, Ala35Val) and p75 NTR (Ser205Leu) genes, within the list of multifactorial aspects, are associated with liver function in different histopathological profiles of patients with chronic viral liver disease in the Brazilian Amazon.

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“…incidence of systemic hypertension reduced in cirrhotic patients due to many factors as abnormally distributed elevated blood volume with reduced effective circulatory blood volume, abnormal sodium and water handling and neurohormonal activation . [3][4].…”

Section: Systemicmentioning

confidence: 99%

Carvedilol versus Band Ligation for Primary Prophylaxis of Variceal Bleeding in ‎Cirrhosis with Systemic Hypertension: A Randomized Controlled Trial

Soliman

Ali²,

Raiss³

et al. 2022

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aims: Up to our knowledge, no study was performed on primary prophylaxis of variceal bleeding in cirrhosis with systemic arterial hypertension. So, we will evaluate the safety and efficacy of carvedilol versus endoscopic band ligation (EBL) for the primary prophylaxis of variceal bleeding in hypertensive cirrhotic patients. Patients and Methods:In this randomized controlled trial, 306 cirrhotic hypertensive patients with large and/or risky esophageal varices were randomized into EBL and carvedilol groups. Carvedilol was given orally at an initial dose of 6.25 mg twice daily, and titrated up to achieve a normotensive response. When maximum of 25mg twice daily was given without satisfactory control of blood pressure, diuretic and enalapril was added.Results: Variceal bleeding within a follow up period of one year was found to be 1.3% in EBL group versus 2.6% in carvedilol group without statistically significant difference (P=0.680).In carvedilol group, systolic blood pressure, diastolic blood pressure and mean arterial pressure were significantly decreased at 3 months of follow up till the end of the study, while heart rate was significantly decreased at 9 months of follow up till the end of the study when compared with the baseline (P <0.001). Adverse events were significantly higher in the EBL group (25.49%) than carvedilol group (10.46%) (P< 0.05). Conclusion:Carvedilol was safe and effective in the primary prophylaxis of esophageal variceal bleeding in cirrhotic patients with systemic arterial hypertension .

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Prevalence of arterial hypertension in cirrhosis of liver

Cited by 5 publications

References 4 publications

Prevalence of arterial hypertension in liver cirrhosis and correlation with the severity of liver disease

Prevalence of arterial hypertension in liver cirrhosis and correlation with the severity of liver disease

NGF (−198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

Carvedilol versus Band Ligation for Primary Prophylaxis of Variceal Bleeding in ‎Cirrhosis with Systemic Hypertension: A Randomized Controlled Trial

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