Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India

Nath, Alok; Khan, Ajmal; Hashim, Zia; Patra, Jeetendra Kumar

doi:10.4103/0970-2113.201300

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…In a study performed by Maurya et al (22), 10.4% of asthmatic patients had positive reaction to Aspergillus - specific IgG. However, in the present study, the level of Aspergillus - specific IgG was 43.0% in patients with asthma.…”

Section: Discussioncontrasting

confidence: 76%

“…In several studies, the positive reaction rates to AST were reported as 21.5% (20), 27.6% (21), and 35.1% (22). Moreover, the levels of total IgE in the current study were low, compared to the results reported by the previous studies (19, 22). The obtained differences in positive rates may be due to varieties in genetic, nationality, race, and geographical and climatic conditions.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma

Hedayati¹,

Mortezaee²,

Mahdaviani³

et al. 2019

CMM

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Background and Purpose: Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) against A.fumigatus in asthmatic patients.Materials and Methods: This study was conducted on 200 consecutive patients with moderate to severe asthma referring to Masih Daneshvari hospital Tehran, Iran, from January 2016 to February 2018. Skin prick test (SPT) was performed in all subjects with Aspergillus allergens. Moreover, all patients underwent specific IgE testing for Aspergillus using Hycor method. Enzyme immune assay was applied to measure total IgE and Aspergillus-specific IgG.Results: According to the results, the mean age of the patients was 45.8 years (age range: 18-78 years). The mean levels of total IgE and Aspergillus specific IgE in asthmatic patients were obtained as 316.3 (range: 6-1300 IU/ml) and 1.5 (range: 0.1-61.3 IU/ml), respectively. Out of 200 patients, 27 (13.5%), 65 (32.5%), 22 (11.0%), and 86 (43.0%) cases had positive Aspergillus SPT, total IgE of > 417 IU/ml, Aspergillus-specific IgE, and IgG, respectively. The level of these variables in patients with severe asthma were 16 (16.5%), 36 (37.1%), 15 (15.5%), and 46 (47.4%), respectively.Conclusion: As the findings indicated, reactivity to Aspergillus is a remarkable phenomenon in asthmatic patients. It is also emphasised that the climatic condition may affect the positive rate of hypersensitivity to Aspergillus.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Prevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma

Hedayati¹,

Mortezaee²,

Mahdaviani³

et al. 2019

CMM

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“…wherein the incidence of ABPA in asthma clinic was found to be 21.7%. [ 10 ] In patients with asthma, bronchiectasis involving three or more lobes, presence of centrilobular nodules, and mucoid impaction highly suggest the possibility of ABPA. [ 8 ] In our study, 64.6% of the patient had bronchiectasis with or without other lung findings.…”

Section: Discussionmentioning

confidence: 99%

Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis

Neyaz

Hashim

Kumar

et al. 2020

Indian Journal of Radiology and Imaging

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Context: Few studies have been done for correlating asthma severity, IgE level, and spirometry results with high-resolution computed tomographic (HRCT) findings in allergic bronchopulmonary aspergillosis (ABPA). Aims: This prospective observational study was conducted to correlate asthma severity, IgE level, and spirometry results with HRCT findings in ABPA. Settings and Design: Prospective observational. Subjects and Methods: Fifty consecutive adult patients with asthma and positive specific IgE (>0.35 kUA/L) to Aspergillus fumigatus were recruited from October 2015 to July 2017. Asthma severity, IgE levels, and spirometry results were correlated with HRCT score, bronchiectasis score, air trapping segments, and low-attenuation lung volume on inspiratory CT and expiratory CT. Statistical Analysis Used: One way ANOVA, Spearman's correlation coefficients. Results: Asthma severity showed a significant positive correlation with HRCT score and bronchiectasis score. MEF pre and postbronchodilator values showed a significant negative correlation with HRCT score, bronchiectasis score, and percentage expiratory volumes -851 to -950 HU voxels. FEV1 prebronchodilator value showed a significant negative correlation with percentage expiratory volume -851 to -950 HU voxels and percentage expiratory volume -851 to -1024 HU voxels. Specific IgE antibody level showed a significant positive correlation with bronchiectasis score. Conclusions: Asthma severity, specific IgE level, and MEF values showed a good correlation with HRCT findings. The restrictive pattern is common on spirometry in patients of ABPA. In addition to central bronchiectasis, peripheral bronchial and small airway involvement was an important finding in ABPA. Expiratory HRCT may reveal air trapping in patients having no abnormality on inspiratory CT.

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“…In a study of 57 patients with severe acute asthma admitted to an intensive care unit, the prevalence of ABPA was found to be 39 per cent (compared to 21% in the outpatient asthma group) 20 . The prevalence of ABPA complicating asthma reported in the last decade is summarized in Table I 21 22 23 24 25 26 27 28 29 30 31 32 . The data suggest a high prevalence of AS and ABPA in special clinics ( Table I ) and a higher prevalence in India compared to other countries.…”

Section: Epidemiology Of Abpamentioning

confidence: 99%

Allergic bronchopulmonary aspergillosis

Agarwal

Sehgal

Dhooria

et al. 2020

Indian Journal of Medical Research

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Allergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease caused by immunologic reactions initiated against Aspergillus fumigatus colonizing the airways of patients with asthma and cystic fibrosis. The common manifestations include treatment-resistant asthma, transient and fleeting pulmonary opacities and bronchiectasis. It is believed that globally there are about five million cases of ABPA, with India alone accounting for about 1.4 million cases. The occurrence of ABPA among asthmatic patients in special clinics may be as high as 13 per cent. Thus, a high degree of suspicion for ABPA should be entertained while treating a patient with bronchial asthma, particularly in specialized clinics. Early diagnosis and appropriate treatment can delay (or even prevent) the onset of bronchiectasis, which suggests that all patients of bronchial asthma should be screened for ABPA, especially in chest clinics. The current review summarizes the recent advances in the pathogenesis, diagnosis and management of ABPA.

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Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India

Cited by 17 publications

References 29 publications

Prevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma

Prevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma

Correlation of asthma severity, IgE level, and spirometry results with HRCT findings in allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis

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